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Biomedical subjects

J Clavert

Publications and source records attributed to J Clavert.

At least 19 recordsLinked to original sources
PubMed1980

Teratogenic and lethal properties of the various fractions of venom of the viper, Vipera aspis.

When whole viper (Vipera aspis) venom is injected into pregnant mice at various times during gestation, several anomalies occur in the fetuses and offspring. The teratogenic targets of the venom include the brain, heart, limbs and face, depending on the day of the injection. In the present study, the various constituents of whole venom were separated by gradient chromatography and the lethal and teratogenic properties of each fraction were determined and compared to the activity of whole and reconstituted venom. Our results imply that a synergy or potentiation exists between the fractions, the overall properties of whole venom being more teratogenic than the sum of its parts.

Animals↗
PubMed1977

[Cytogenetic study of 350 mental deficient patients at medico-pedagogic institutions].

This report brings to light the results of cytogenetic study carried out on 350 mentally retarded persons (medium: Group I, deep Group II). In 8,2% and 12,56% of the cases a chromosomic abnormality is observed (mainly trisomy 21). These percentages are in correlation with the results of other studies. Ante and peri natal pathology plays a very important part among exogenous factors. In numerous cases a multifactors etiology can be found as the cause of this mental retardation, the effect of an initial organic mental retardation being aggravated by precocious affective perturbations. For those cases without apparent etiology, a teratologic origin may be thought as their cause.

Adolescent↗
PubMed1975

Lack of development, factor of congenital ureterohydronephrosis.

Female Swiss mice (25-30 g) received a single subcutaneous injection of 200 mug nucleotoxic substance (chloraminophen) on day 11 of pregnancy. The fetuses taken from the treated mother on day 18 show a significant lack of development and urinary anomalies, such as ureterohydronephrosis (26%) and renal agenesis (few cases). Ureterohydronephrosis seems to be caused by lacking development of the ureterovesical junction region.

Abnormalities, Drug-Induced↗