Biomedical subjects

J Coelho

Publications and source records attributed to J Coelho.

22 records · Page 2Linked to original sources

PubMed1985

Dynamics of beta-adrenoceptor blockade with cetamolol.

Cetamolol is a new beta-adrenoceptor blocking agent shown in animals to have moderate beta 1-adrenoceptor selectivity and partial agonist activity. In healthy normal volunteers, beta 1-adrenoceptor blockade was measured as the reduction of exercise-induced tachycardia, systolic blood pressure, and double product at 2, 8, and 24 h after a single oral dose of 10, 25, and 50 mg cetamolol. beta 1-adrenoceptor blockade was significantly linearly related to log serum cetamolol level, was maximal at 2 h, and was still clinically significant at 24 h. A crossover study of single 0, 10, and 25 mg doses confirmed these findings.

Acetamides↗

PubMed1982

Propranolol dosage, plasma concentration, and beta blockade.

One hundred sixty-nine normal men received varying propranolol dosage regimens and placebo. Dose level and frequency were compared with plasma propranolol levels and beta blockade, as assessed by reduction of exercise tachycardia. Propranolol levels above 20 ng/ml induced significant beta blockade. An average daily propranolol dose slightly in excess of 160 mg led to a minimum plasma level above 20 ng/ml. Approximately 50% of subjects achieved 20 bpm or greater decrease in exercise tachycardia with 160 mg per day. The degree of beta blockade at the daily minimum propranolol level was related to dose and not dose frequency. The relation of propranolol dose and plasma levels to beta blockade in normal subjects appears to reflect observations in large clinical trials.

Adolescent↗

PubMedDate not supplied

Clinical and laboratorial study of 19 cases of mucopolysaccharidoses.

UNLABELLED: The mucopolysaccharidoses (MPS) are a heterogeneous group of inborn errors of lysosomal glycosaminoglycan (GAG) metabolism. The importance of this group of disorders among the inborn errors of metabolism led us to report 19 cases. METHOD: We performed clinical, radiological, and biochemical evaluations of the suspected patients, which allowed us to establish a definite diagnosis in 19 cases. RESULTS: Not all patients showed increased GAG levels in urine; enzyme assays should be performed in all cases with strong clinical suspicion. The diagnosis was made on average at the age of 48 months, and the 19 MPS cases, after a full clinical, radiological, and biochemical study, were classified as follows: Hurler - MPS I (1 case); Hunter - MPS II (2 cases); Sanfilippo - MPS III (2 cases); Morquio - MPS IV (4 cases); Maroteaux-Lamy - MPS VI (9 cases); and Sly - MPS VII (1 case). DISCUSSION: The high relative frequency of Maroteaux-Lamy disease contrasts with most reports in the literature and could express a population variability.

Adolescent↗

PubMedDate not supplied

[The incidence of cerebrovascular accidents in the town of Rivera, Uruguay].

INTRODUCTION: Knowledge about the epidemiology of cerebrovascular accidents (CVA), or stroke, in the town of Rivera, Uruguay, would be useful as the basis on which to apply health care strategies both in the prevention of risk factors and in early diagnosis and treatment. AIMS: To determine the incidence of CVA in the town of Rivera and to study the association between certain risk factors and the pathological type of CVA. PATIENTS AND METHODS: The study, which spanned the period between 1st March 2000 and 28th February 2001, was conducted in the town of Rivera, which has a population of 62,859 and is located in the north of the Eastern Republic of Uruguay. The sample consisted of 114 patients with CVA, of whom 79 had no previous history of CVA -first CVA in lifetime (FCVAL)-. RESULTS AND CONCLUSIONS: The incidence of CVA was 181.3 cases per 100,000 inhabitants per year. The incidence of FCVAL was 125.7 cases per 100,000 inhabitants per year. 73.4% of the FCVAL were ischaemic and 26.6% were haemorrhagic. A high percentage of arterial hypertension was found in patients with CVA (84%) and with FCVAL (80.7%), and a statistically significant association was observed between congestive heart failure and ischaemic CVA.

Adult↗