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J Coget

Publications and source records attributed to J Coget.

At least 19 recordsLinked to original sources
PubMed1984

[Arterial Doppler in Horton's disease. A prospective study of 24 cases].

The authors studied the role of Doppler ultrasonography in the diagnosis of Horton's disease, the assessment of the ophthalmic risk and the management of therapy. The study involved 24 patients and 20 control patients (mean age: 68 years) without inflammatory arteritis. A score (0 to 3) was established according to the degree of abnormality of blood flow. 12 patients were regularly followed up over a 2 year period. 83 p. 100 of the temporal arteries examined were pathological, 50 p. 100 of which had severe stenoses (scores 2 and 3). The facial, occipital and ophthalmic arteries were commonly involved (79 p. 100 of arteries examined), as was the central artery of the retina (92 p. 100, with 53 p. 100 of scores 2 and 3), although only 15 patients had minor (11 patients) or major (4 patients) ocular symptoms. However, a close correlation was observed between the presence of ocular symptoms and the severity of the stenoses observed on the central artery of the retina. The low incidence of signs of stenosis in the control group explains the excellent specificity of the Doppler examination (95 p. 100). Improvement with steroid therapy took at least 3 months and correlated well with the clinical and biological response. Blood flow changes reverted to normal in 4 patients after 1 year's treatment; 3 patients had relapses which were always associated with aggravation of the Doppler signs of stenosis. This study shows that Doppler ultrasonography is a valuable diagnostic tool, helps establish a prognosis and manage therapy in Horton's disease.

Aged↗
PubMed1983

Reinnervation of striated muscle by peripheral vagal fibres cut above or below the nodose ganglion in the cat and rabbit.

In cats and rabbits, the peripheral stump of the vagus nerve cut above the nodose ganglion (supranodose anastomoses: s.n.) or below this ganglion (infranodose anastomoses: i.n.) was either sutured with epineurial sutures to the peripheral stump of the branch of the spinal accessory motor nerve innervating the sterno-cleido-mastoid (s.c.m.) muscle, or directly implanted in this muscle after resection of its motor nerve. After about six months, reinnervation of this muscle by vagal fibres was studied. By electromyographic recording during electrical stimulation of the cervical vagus nerve, it was shown that the vagal reinnervation of the s.c.m. muscle was established in 65% of the cats studied (57% s.n., 69% i.n.) and 33% of rabbits (37% s.n. and 31% i.n.). The average number of distinct potentials recorded in the reinnervated muscle, following vagal stimulation, was twenty-two in s.n. cats, thirteen in i.n. cats, eleven in s.n. rabbits and twelve in i.n. rabbits. Recorded potentials were monophasic (8%), biphasic (22.5%), triphasic (11.5%) or polyphasic (58%). These potentials were abolished by curare and alpha-bungarotoxin. The use of retrograde axonal transport of horseradish peroxidase showed labelled cells in the nodose ganglion, the cervical vagus and cranial thoracic vagus, and in the stellate ganglia. It is concluded that cholinergic vagal afferents reinnervated the s.c.m. muscle. Involvement of the sympathetic system is discussed.

Action Potentials↗
PubMed1978

Human somatic chromosome chains and rings. A preliminary note on end-to-end fusion.

Chain and ring chromosome configurations were detected in a small percentage of the lymphocytes of a patient suffering from Thiberge-Weissenbach syndrome. Precise recognition of the chromosomes involved in the rearrangements did not indicate a systematic order of end-to-end fusions. A relationship between these configurations and the chromosome arrangement in the interphase nucleus is possible.

Calcinosis↗
PubMedDate not supplied

[Medical and surgical therapies. Their respective indications in lymphedema].

The treatment of lymphedema, medical or surgical, remains a difficult one. Often seen at an advanced stage of the disease, the medical treatment can only stabilize the lesions. Among them, the coumarins, rutins, Centella asiatica extracts, procyanoside oligomers are the most prescribed. But prophylaxis of superimposed infections by antibiotics should not be omitted. As for diuretics, they must be prohibited. Hygienic and dietetic measures should be recommended. As for surgical treatments, they are numerous and rarely applied, whether it consists of the tacking technique or Degni's lymphovenous anastomosis. The latter may be considered in case of high lymphatic obstruction, especially at the inguinal level. Servelle's lymphangiectomy, very traumatic, is only exceptionally indicated.

Adolescent↗