Biomedical subjects
Publications and source records attributed to J Coignet.
The authors describe one case of Moebius syndrome in a neonate; the syndrome is uncommon. It includes congenital oculofacial palsy and limb malformations; other cranial nerves are sometimes involved. The etiology is unknown: genetic or embryopathic (infection or toxic). Pathogeny is unclear: nervous or muscular aplasia; neurocristopathy or dysgenesis of the two first branchial arches. The treatment is medical and chirurgical.
We report a case of mononuclear phagocyte system activation observed in a 12 month-old girl presenting with fever, hepatosplenomegaly, pancytopenia, histiocytic hyperplasia with hemophagocytosis in the bone marrow, high triglyceride and low fibrinogen blood levels. This syndrome was associated with visceral leishmaniasis. We conclude that systemic leishmaniasis is a curable cause of disorders characterized by an activation of the mononuclear phagocyte system.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Pharmacokinetic studies of amikacin were investigated concomitant with the kidney and auditory function and with the minimal inhibitory concentrations on the causal bacteria in 23 premature neonates with confirmed or suspected infections. It appears that the usual doses administered to newborns or preterm neonates must be decreased and calculated in function to the gestational ages and life's days. Every preterm neonates received a first infusion of 7.5 mg/kg. When premature have less than 14 days of life, amikacin was given at a dose of 3.75 mg/kg every 12 hr for a gestational age less than 32 weeks, or 5 mg/kg every 12 hr for a gestational age between 32 and 37 weeks. After 14 days of life, considering our results it must be necessary to administer 5 or 7.5 mg/kg every 12 hr.
Explore the source record for details and available documents.
Based on a review of the literature, the authors present the indications for Primperan in paediatrics. The anti-emetic and motor properties of Primperan can be useful in the treatment of gastro-intestinal disorders in infants and children, gastro-duodenal dyskinesia and gastro-oesophageal reflux, but it is also useful for the radiological or endoscopic diagnosis of these conditions and in anaesthetics.
Three new cases of partial trisomy of the chromosome 8 short arm are reported. The observations confirm and extend certain clinical, enzyme, and chromosomal data in this type of chromosomal anomaly.
Explore the source record for details and available documents.
An unbalanced Y autosome translocation t(5;Y) and an apparently balanced translocation t(2;13) are identified with the Q and R banding in a 7-year-old boy with severe encephalopathy and a multiple malformation syndrome. At birth, the clinical diagnosis of 'cri du chat' syndrome based on the characteristic crying was not confirmed after karyotyping, using conventional staining techniques.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.