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J Collazos

Publications and source records attributed to J Collazos.

At least 73 records · Page 4Linked to original sources
PubMed1995

Massive reversible pulmonary cysts in a patient with AIDS.

We report the case of a patient with AIDS who presented with bilateral, massive pulmonary cystic disease and pneumothorax presumably caused by Pneumocystis carinii which responded to treatment with cotrimoxazole. Follow-up with sequential chest X-rays and computed tomography scans showed a progressive improvement in the lung cysts which had resolved almost completely 11 months later. Several theories have been proposed to explain the cavitary lesions in this infection. The course observed in our patient suggests that a non-destructive mechanism was responsible for his lung cysts.

AIDS-Related Opportunistic Infections↗
PubMed1995

Angina pectoris following cisplatin, etoposide, and bleomycin in a patient with advanced testicular cancer.

OBJECTIVE: To report a case of angina pectoris associated with chemotherapy for testicular cancer. CASE SUMMARY: An HIV-infected patient with massive retroperitoneal metastases of a mixed embryonal and undifferentiated teratocarcinoma was treated with cisplatin, etoposide, and bleomycin. While the patient was receiving the second course of chemotherapy, he developed several episodes of angina pectoris that responded to nitroglycerin. Coronary angiography excluded structural abnormalities in the coronary arteries. The patient was treated prophylactically with nifedipine during the 2 following courses of chemotherapy with no new ischemic events. DISCUSSION: Coronary vasospasm seemed to be responsible for the angina in this patient. Several pathogenetic mechanisms that could explain these vascular events are discussed, including the possible role of bulky metastatic disease. CONCLUSIONS: The combination of cisplatin, etoposide, and bleomycin for testicular cancer, perhaps associated with bulky metastatic disease, can induce vasospastic phenomena that might be life-threatening.

Adult↗
PubMed1994

Cancer of the ovary.

Explore the source record for details and available documents.

Antigens, Tumor-Associated, Carbohydrate↗
PubMed1994

Aspergillus pneumonia successfully treated with itraconazole in a patient with systemic lupus erythematosus.

The case of a patient with systemic lupus erythematosus who developed pneumonia caused by Aspergillus fumigatus is described. She was treated with itraconazole 200 mg twice daily, with a rapid response. After a follow-up period of 5 years no recurrence of the infection has been detected. To our knowledge this is the first report on the use of itraconazole in patients with systemic lupus erythematosus. Considering the poor prognosis associated with Aspergillus pneumonia in patients with systemic lupus erythematosus, we believe that itraconazole constitutes a safe and effective alternative to amphotericin B in these patients.

Adult↗
PubMed1994

Role of the measurement of serum procollagen type III N-terminal peptide in the evaluation of liver diseases.

Serum N-terminal procollagen-III peptide (PIIIP) was measured in 151 patients with diverse liver diseases together with other clinical and laboratory data. Patients with cirrhosis had higher serum PIIIP than those without cirrhosis (P < 0.0001). Significant associations were found between PIIIP and many data characteristic of liver diseases, including alcohol markers. Serum PIIIP was also associated with portal hypertension (P = 0.0001), although such association was probably due to the fact that most patients with portal hypertension were cirrhotic patients. The predictive values of PIIIP in portal hypertension were too low to be clinically useful. No one single factor could be identified as responsible for the increase in PIIIP and the data suggest that the mechanism is multifactorial. Measurement of serum PIIIP has a limited clinical value in the evaluation of patients with diverse liver diseases.

Adolescent↗
PubMed1994

Serum laminin levels offer only a little additional information in liver disease.

We have measured serum laminin, a marker of portal hypertension, in 151 patients with nonmalignant liver diseases, to evaluate its utility in cirrhosis and portal hypertension. There were abnormal serum levels in 43.1% of the patients as a whole and in 62.7% of the cirrhotics. Laminin showed a correlation with many laboratory tests, especially those that reflect liver insufficiency and alcohol intake. Cirrhotics had higher laminin levels than noncirrhotics (p < 0.0001); an association was also found with portal hypertension (p < 0.0001), but laminin was also increased in patients without portal hypertension. Our results suggest that liver dysfunction can also lead to abnormal laminin concentrations, probably through slower metabolization rate. Laminin serum concentrations reflect the severity of the liver disease, and are also a marker of alcohol consumption. Determination of laminin serum levels could play an adjunctive role with respect to other liver tests in the evaluation of these patients although the measure does not really provide more useful information.

Adolescent↗
PubMed1994

Multiple strokes after initiation of steroid therapy in giant cell arteritis.

We report the case of a 66 year old woman with clinical manifestations of giant-cell arteritis, positive temporal artery biopsy and excellent response to prednisone, who developed massive cerebral infarcts after 5 days of treatment. Computed tomographic and magnetic resonance imaging scans revealed multiple infarcts in areas irrigated by both the carotid and vertebrobasilar systems bilaterally. A four-vessel angiography performed 19 days later revealed only mild atheromatous disease. Anticardiolipin antibodies were negative and a transoesophageal echocardiogram was normal. Stroke during the first 2 weeks of therapy in giant-cell arteritis, especially in the vertebrobasilar territory, has been previously reported. Anticoagulation during the first weeks of steroid treatment in these patients might be advisable.

Aged↗
PubMed1994

Measurement of the serum tumor marker neuron-specific enolase in patients with benign pulmonary diseases.

Serum concentrations of neuron-specific enolase (NSE) were measured in 135 patients with benign pulmonary diseases who also underwent a clinical, laboratory, and radiologic evaluation. Eleven percent of the patients as a whole and 27.3% of those who were tuberculous had abnormal serum levels of NSE. Significant differences in NSE levels were observed among the six diagnostic groups evaluated (p = 0.002). Males had higher levels than females (p = 0.003), and patients infected with the human immunodeficiency virus (HIV) had higher NSE levels than those not infected (p = 0.0026). Patients with alveolar infiltrates or an interstitial pattern on chest X-ray had higher NSE levels than those with normal radiographs (p = 0.003 and p = 0.01, respectively). In fact, only 3.6% of the patients with normal radiographs had above-normal levels of NSE. Direct damage to the neural or neuroendocrine lung cells or some degree of local hypoxia is likely to play a role in the increase in NSE in these patients. The small number and degree of abnormal values of NSE observed in this study make it unlikely that an underlying benign lung disease will substantially modify the interpretation of an increased NSE value in patients with lung cancer. However, care should be taken in interpreting a moderately abnormal NSE value in the cancer patient in the presence of lung infiltrates such as obstructive pneumonitis.

Acquired Immunodeficiency Syndrome↗
PubMed1994

[Seroprevalence of delta virus and hepatitis C virus in patients with chronic infection with hepatitis B virus].

OBJECTIVE: To study the prevalence of hepatitis delta and hepatitis C viruses (HDV and HCV) in patients infected with hepatitis B virus (HBV) with and without risk behaviors for the infection by these viruses and by the human immunodeficiency virus (HIV). MATERIALS AND METHODS: Clinical and serological study (January 1990-December 1992) at Medicine Service at Galdacano Hospital of 109 patients with positive hepatitis B surface antigen and without clinical or serological evidence of acute hepatitis, 60 without risk behaviors for the infection, 45 parenteral drug abusers (PDA) and 4 homosexual males. RESULTS: Chronic HDV infection was observed in 60% of PDA and more frequently among HIV-positive patients (p < 0.05). In six of these patients the serological determination of HDV-Ag was positive. Chronic HDV and HCV infection rates in patients without risk behaviors were 1.6% and 16%, respectively. Eighty-eight percent of PDA had anti-HCV; no differences were observed between HIV-positive and HIV-negative patients (p = 0.64). CONCLUSIONS: HDV was particularly associated with parenteral drug abuse, with a similar prevalence to other surveys conducted in Spain. The higher frequency of HDV and HDV-Ag among HIV-positive patients could indicate a greater susceptibility to HDV in clinical conditions associated with immunosuppression. HCV infection occurs at early stages and is common among PDA infected with HBV, with no apparent association with patient's age, years of drug abuse or HIV infection.

Adolescent↗