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Biomedical subjects

J Compton

Publications and source records attributed to J Compton.

29 records · Page 2Linked to original sources
PubMed1986

Synergistic activity of amikacin with aztreonam against Pseudomonas aeruginosa and other gram-negative organisms.

The effects of amikacin in combination with aztreonam were tested on 100 strains of gram-negative bacteria by means of the microtiter checkerboard system. Eighty-one strains were Pseudomonas aeruginosa, eight were Enterobacter species, seven were Acinetobacter species, two were Alcaligenes species, one was a Citrobacter organism, and one was Pseudomonas stutzeri. All strains had a minimal inhibitory concentration (MIC) to aztreonam between 4 and 256 micrograms/ml (MIC50 = 16 micrograms/ml) and an MIC to amikacin between 8 and greater than 128 micrograms/ml (MIC50 = 16 micrograms/ml). A synergistic effect (fourfold less MIC when both aztreonam and amikacin were present) was observed for 40 (49%) of 81 P aeruginosa and three (16%) of 19 of the other strains tested. All the remaining test strains showed an additive response; no antagonism was observed. The MICs to aztreonam and to amikacin for 98% of strains that exhibited synergism ranged from 2 to 32 micrograms/ml.

Amikacin↗
PubMed1983

Role of the intensive care ambulance in the transport of accident victims.

The performance of intensive care ambulance officers (paramedics) has been assessed by an analysis of interventions and outcomes in 75 patients transported by ambulance services to the Westmead Centre following accidents. An injury severity score has been used to compare anticipated with actual results. It appeared that some 20% of patients benefited from paramedical interventions, that some 10% reached hospital alive because of the interventions, and that about 3% survived in the long term because of the interventions. Ambulance officers showed themselves to be accurate in assessing the severity of trauma.

Accidents, Traffic↗
PubMed1976

The use of o-dianisidine for serum haptoglobin electrophoresis using cellulose acetate.

1. Due to the carcinogenicity of benzidine, a method by which o-dianisidine is used to stain serum haptoglobin is described. Serum haptoglobin is determined by electrophoresis using cellulose acetate as the medium. 2. A comparison of the two staining systems demonstrates good agreement. 0-Dianisidine can be substituted for benzidine without loss of specificity.

Dianisidine↗
PubMedDate not supplied

Trauma outcomes: a death analysis study.

Survival and mortality outcomes for trauma patients admitted to Liverpool Hospital, Sydney were analysed to determine the adequacy of trauma care. TRISS and ASCOT survival probabilities and peer review were utilised to determine if deaths were avoidable. Evaluation methods were compared for assessment of care. During the study period 2205 trauma patients were admitted, 518 of which fulfilled the study entry criteria. There were 38 deaths. The age and Injury Severity Score (ISS) of survivors was 34 +/- 18 years, 9.8 +/- 9 (mean +/- sd) compared to age and ISS for nonsurvivors 37 +/- 22 years and 45 +/- 22*, *p < 0.001. Peer review suggested that 32 deaths were non avoidable, 4 potentially avoidable and 2 were probably avoidable. TRISS and ASCOT survival probabilities were > 0.5 in 16 and 18 patients respectively. TRISS and ASCOT had low positive predictive value (25%) in identifying avoidable deaths. The Z Score was 1.79. The standardised mortality ratio (SMR) was 1.16. The Effectiveness (E) value for outcome was 0.91. Poor communication within the Area Trauma System was the greatest contributor to avoidable deaths. All trauma deaths need peer review rather than solely relying upon ASCOT and TRISS probabilities to identify "unexpected" deaths for detailed review.

Adolescent↗
PubMedDate not supplied

Cytodiagnosis of Hodgkin's disease in sputum specimens.

In patients with histologically proven Hodgkin's disease, knowledge of the extent of involvement of lymph nodes and other organs has proven valuable in the determination of treatment and prognosis. One of the most common sites of involvement outside the hematopoietic system has been shown to be the lung parenchyma; in this study, six patients with a tissue-proven diagnosis of Hogdkin's disease and positive cytologic findings in the sputum were reviewed. Three cell types not found in normal sputum specimens were identified in these patients and were correlated with the histologic patterns of the tumors as seen in lung biopsies. Our results suggest the usefulness of sputum examination as an adjunctive or possibly a substitute diagnostic procedure in the evaluation of patients with Hodgkin's disease and possible lung involvement. They also suggest that in some cases the cytologic diagnosis can be quite specific in the identification of neoplastic cells as consistent with a diagnosis of Hodgkin's disease.

Adult↗