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Biomedical subjects

J Comsa

Publications and source records attributed to J Comsa.

At least 19 recordsLinked to original sources
PubMed1979

Influence of the adrenal cortex on allograft rejections in rats.

I. The bibliography about corticosteroid influence on immune response is briefly reviewed. Generally, it is admitted that corticosteroids are immunosuppressive when administered in large amounts. Divergent opinions are recalled. II. The aims of the experiments are summarized: A) Investigate on the influence of corticoids (given in just substitutive amounts) on skin allograft rejection. B) Investigate on possible interactions between adrenal cortex and thymus with this test. III. It was observed, that A) Adrenalectomy resulted in a significant delay of allograft rejection. B) This could be suppressed partially by administering aldosterone, corticosterone, and desoxycorticosterone and completely by administering at least two of these hormones. C) Cortisol had shown a minor inhibitory influence. D) There was no obvious difference between adrenalectomized and thymectomized rats and those adrenalectomized only. IV. These observations are replaced in the context of bibliography and their significance is discussed.

Adrenal Cortex↗
PubMed1979

[Influence of the thymus hormone on radioleucosis in mice].

A partially purified thymic extract has determined the development of leucosis in 10 thymectomized irradiated CC57Bl mice out of 25. The pure hormone isolated from the same extract prevented the development of leucosis in intact irradiated Mice. This seems to indicate the presence of a second active substance in the extract (enhancing the development of the leucosis).

Animals↗
PubMed1979

Hormonal influences on the secretion of the thymus.

The bibliography concerning the interaction of the thymus with other endocrines is summarized. The thymus, the lymph nodes and the spleen of Sprague-Dawley rats were extracted with the method of Bezssonoff and Comsa and the extracts fractionated with the method of Bernardi and Comsa. The animals were (1) normal, (2) adrenalectomized, (3) adrenalectomized and substituted with one or several corticosteroids, (4) adrenalectomized and thymectomized, (5) thyroidectomized, (6) thyroidectomized and substituted with thyroxine, (7 and 8) castrated (males or females), (9 and 10) castrates substituted with sexual hormones, (11) castrated and adrenalectomized, (12) castrated and thyroidectomized, (13) castrated, adrenalectomized and thyroidectomized, (14) hypophysectomized, and (15) hypophysectomized and substituted with one hypophyseal hormone. In the Bernardi-Comsa preparations hormone was determined by UV-spectrophotometry. Adrenalectomy resulted in a significant decrease of the hormone content of the thymus (which was still more attenuated by cortisol) and its increase in the lymph nodes and the spleen. Corticosterone and desoxycorticosterone increased the hormone content in all three tissues, whilst aldosterone increased it in the thymus and decreased it in the lymph nodes and the spleen. Thyroidectomy resulted in a significant decrease of the hormone in the thymus and its quasi-disappearance from the lymph nodes and the spleen. This was prevented by thyroxine therapy. Castration resulted in an increase of the hormone content in all three tissues. This was prevented by sexual hormone therapy. Hypophysectomy resulted in decrease of the hormone content in all three tissues. This was prevented by injections with growth hormone, corticotropin and thyrotrophin. These results were compared with those of histological examinations of thymus, lymph nodes and spleen in the corresponding experimental groups. The consistency was found satisfactory.

Adrenalectomy↗
PubMed1977

Effects of thymectomy on the endocrine glands of the rat.

The effects of thymectomy on the thyroid gland, the adrenal cortex, the testes and the lymph nodes of the rat follow the same pattern as those observed in guinea pigs but in a very attenuated form. Thymectomized rats do not show the wasting observed in thymectomized guinea pigs. The effects on the adenohypophysis are approximately the same in rats and guinea pigs, but the sequence of the changes is different. Injections of thymic extract or of presumably pure thymic hormone suppressed all the effects of thymectomy on the endocrine glands of the rat. In rats, thymic hormone was found in the thymus, the lymph nodes and the spleen. It disappeared from the lymph nodes and the spleen within three days of thymectomy and did not reappear, although most of the changes in the endocrine glands were transitory. The implications of the observations for understanding the consequences of thymectomy are discussed.

Adrenal Cortex↗
PubMed1975

Influence of the thymus-corticothropin-growth hormone interaction on the rejection of skin allografts in the rat.

Skin allograft rejection was noticeably delayed in rats following hypophysectomy. Daily injections of hypophyseal growth hormone restored the normal reaction. Additional thymectomy had no influence on the rejection of hypophysectomized rats. In these animals growth hormone by itself had no significant influence on the graft rejection. It only restored a normal reaction when given together with thymic hormone. Corticotropin injections accelerated the allograft rejection. On this action of corticotropin thymic hormone has shown a significant inhibitory influence. The thymus was thus proved to be a synergist to growth hormone and an antagonist to corticotropin. Previous observations made with usual endocrinological test- are thus confirmed with an immunological test.

Adrenocorticotropic Hormone↗