PubMed Health⌕ Search

Biomedical subjects

J Cook

Publications and source records attributed to J Cook.

At least 253 records · Page 14Linked to original sources
PubMed1979

Inhibition of sebum excretion by an H2 blocker.

Cimetidine, 1g orally per day, partially inhibited sebum excretion in patients with acne. Whether this was the result of H2-receptor blockade or an antiandrogen action is unknown.

Acne Vulgaris↗
PubMed1979

Central nervous system changes complicating the use of radiotherapy for the treatment of a nasopharyngeal neoplasm in a diabetic patient.

A case is reported of a diabetic patient with a nasopharyngeal neoplasm who developed radiation induced brainstem damage even though irradiated at a conventional time-dose-volume relationship. The clinical course was correlated with autopsy findings which revealed radiation changes in the brainstem consisting primarily of vascular hyalinization with foci of infarction, edema, and demyelination. Atherosclerotic changes were conspicuously absent and therefore not the case of the alterations. The changes occurred three months after completion of therapy, which was more rapid than expected for radiation injury. It is hypothesized that diabetes may have predisposed the patient to this severe complication of standard therapy. More needs to be learned concerning the relationship between diabetes mellitus and radiation complications. Perhaps a modified time-dose relationship should be considered.

Adult↗
PubMed1979

Hemodialysis with glycerol dialysate.

Glycerol has a rate and volume of distribution similar to urea. Thirty-six mM glycerol in the dialysate prevents the fall in serum osmolality but does not decrease symptoms or improve the vascular stability of patients on chronic hemodialysis. We suggest that the benefits of mannitol, sodium and glucose in preventing or reversing symptoms during chronic dialysis are due to their extracellular distribution.

Animals↗
PubMed1979

Hospital cost per case: analyses using a statewide data system.

In this paper, we establish relationships between hospital cost per case and the independent variables; case mix complexity, case mix severity, factor input prices, and hospital characteristics. Two hundred and sixteen thousand discharges from Maryland's acute general hospitals are grouped into 383 Diagnostic Related Groups which are used to compute an information theoretic measure of case mix complexity. Multiple linear regression equations are developed which predict up to 88% of the variance of between-hospital cost per case. The most highly significant predictors of cost per case are complexity, patient age, proportion of high risk patients, average length of stay, and nonphysician salary levels. Two distinct groups of hospitals, metropolitan and rural, are defined and models are developed for each. We discuss the implications of these findings for the identification and regulation of unexpectedly high cost hospitals and for prospective cost per case reimbursement.

Analysis of Variance↗
PubMed1979

Infection of total hip prostheses by Peptococcus magnus: an immunofluorescence and ELISA study of two cases.

In two cases of infected total hip replacements, Peptococcus magnus was isolated in pure culture from the implant when it was removed. Fluorescent antibody and ELISA studies have shown that both patients developed an antibody response to this anaerobic coccus soon after the replacement operation. These results suggest that the organism is a true infective agent, which was probably responsible for the failure of the arthroplasty operation.

Aged↗
PubMed1979

The influence of availability of free school milk on the height of children in England and Scotland.

The effect is investigated of availability of free school milk on height gain in one year of six- and seven-year-old primary schoolchildren in England and Scotland, using data collected annually from 1972 to 1976. The height gain of children for whom milk was available for the whole year of observation was compared with that of children who had no milk. Out of 16 sex-country-year-specific analyses for children from manual social classes only, 13 showed no significant evidence of greater height gain in children who had milk. Comparison of children from Social Classes IV and V (semi-skilled and unskilled) showed no greater increase in height for those who had milk, nor was there a difference in height gain between manual social class children according to the number of glasses of milk they drank a day at home or at school. We concluded that, given the standard of living at the time of the survey, the drinking of free school milk did not increase the growth rate of six- and seven-year-old children.

Animals↗
PubMed1977

Haemoperfusion with R-004 Amberlite resin for treating acute poisoning.

Eleven patients who had taken overdoses of barbiturates, glutethimide, tricyclic antidepressants, and chloroquine were treated by resin haemoperfusion using an R-004 haemoperfusion cartridge containing XAD-4 resin. All but one patient showed rapid clinical recovery and the drugs were cleared rapidly from the plasma. There were few complications. Resin haemoperfusion is more effective than dialysis and other perfusion methods, especially in poisoning with tricyclic antidepressants. Although haemoperfusion is expensive, it greatly reduces the length of the patient's stay in an intensive care unit and hence is cost-effective.

Acute Disease↗
PubMed1977

Abdominal wound dehiscence. A 10-year survey from a district general hospital.

The incidence of abdominal wound dehiscence at a district general hospital was found to be about 1.5%. Analysis of a group of 123 patients with dehiscence in 3 separate years during a 10-year period confirmed that disruption most commonly occurs during the second postoperative week. The suture material used for primary closure appeared to have no influence on subsequent dehiscence. After resuture the recorded incidence of incisional herniation was 19% and the mortality was 24%. Patients who survived resuture remained in hospital for a prolonged period.

Abdomen↗