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Biomedical subjects

J Cornelis

Publications and source records attributed to J Cornelis.

9 recordsLinked to original sources
PubMed1991

Do you also have problems with the file format syndrome?

In a biomedical data processing environment, an essential requirement is the ability to integrate a large class of standard modules for the acquisition, processing and display of the (image) data. Our approach to the management and manipulation of the different data formats is based on the specification of a common standard for the representation of data formats, called 'data nature descriptions' to emphasise that this representation not only specifies the structure but also the contents of data objects (files). The idea behind this concept is to associate each hardware and software component that produces or uses medical data with a description of the data objects manipulated by that component. In our approach a special software module (a format convertor generator) takes care of the appropriate data format conversions, required when two or more components of the system exchange data.

Electronic Data Processing↗
PubMed1990

A monoclonal antibody to Ly-6 gene product inhibits generation of functionally active T cells and recognizes single antigenic specificity whose expression is up-regulated in virus-transformed rat fibroblast.

In order to elucidate the relationship between the structure and function of proteins encoded for by the Ly-6 gene complex, a cDNA was constructed for a Ly-6.2 specificity and then monoclonal antibodies (mAb) generated to bacterially synthesized protein. The addition of one of these mAb, designated Pb-19, inhibited the proliferative response of T cells to concanavalin A (Con A) or major histocompatability complex (MHC) alloantigens. Reactivity of Pb-19 to the Ly-6 specificity was blocked by a known anti-Ly-6.A.2 mAb but not by an anti-Ly-6.E.1 mAb. This mAb detected a Ly-6.A.2 specificity (a 33,000 MW antigen) whose expression was increased in a transformed rat fibroblast containing the entire genome of bovine papillomavirus.

Animals↗
PubMed1985

[Reactivation of gamma-ray irradiated parvovirus H-1 in cells of patients with ataxia telangiectasia and Huntington's chorea].

Parvovirus H-1 was used to probe the cellular radiosensitivity of two human degeneration syndromes AT and HC. No difference in the survival of gamma irradiated H-1 was detected between skin fibroblasts from such patients and from a normal individual. However, AT and normal cells were distinguished by the fact that the reactivation of irradiated H-1 could be increased by UV or X-irradiation of the latter but not of the former cells.

Animals↗
PubMed1976

An active probe for electrocardiography.

In order to improve the signal to noise ratio during the recording of electrocardiographic maps from moving patients, the effect of using active electrodes with built-in amplifiers was investigated. Two kinds of electrodes using different technologies were developed: a miniature printed circuit and a thin film circuit. The first method was found to be suitable for the fabrication of small quantities in a normally equipped electronics workshop while the second, requiring highly specialised equipment, is intended for industrial manufacture in large quantities.

Amplifiers, Electronic↗
PubMedDate not supplied

Transformation of established murine fibroblasts with an activated cellular Harvey-ras oncogene or the polyoma virus middle T gene increases cell permissiveness to parvovirus minute-virus-of-mice.

Transformation of permanent rodent fibroblast cells by the polyoma virus middle T gene or the activated human Harvey-ras oncogene results in increased cellular permissiveness to the autonomous parvovirus minute-virus-of-mice. Parvoviral DNA amplification is restricted in the untransformed parental cell lines. Analysis of various parameters of the parvoviral life cycle shows that this block is partially overcome in the transformed lines.

Animals↗