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Biomedical subjects

J Cottet

Publications and source records attributed to J Cottet.

At least 19 recordsLinked to original sources

[Two thousand years of historical study on the words atheroma, atheromatosis, atherosclerosis, arteriosclerosis].

Renowned authors, when studying arterial diseases, use indifferently the words atheroma, atheromatosis, atherosclerosis or arteriosclerosis. The historical record of these words permits the justification of a selective choice. The word atheroma was created by Celsius, two thousand years ago; he have it the meaning of fatty tumor, which was kept till the middle of the nineteenth century. The word atheromatosis appeared on 1815, since J. Hodgson defined so the fatty arterial degeneration. Marchand, from Leipzig, proposed on 1904 the word atherosclerosis which has always been with us. The term arteriosclerosis was well defined on 1833 by Lobstein, from Strasbourg. The authors propose to reserve the word atherosclerosis to the arterial disease described by the WHO, to keep the words atheroma and atheromatosis to anatomical lesions well-defined. Arteriosclerosis is a disease which invades an extensive arterial network, with a particular anatomical image.

Arteriosclerosis

[From cholesterol to lipoprotein particle markers and/or risk factors].

Among the risk factors for atherosclerosis, lipoproteins play a central role, particularly in the development of coronary artery disease. The plasma cholesterol level was the first definite indicator of the risk factor. Thereafter, technical progress has permitted the measurement of the cholesterol fractions, LDL cholesterol which is positively correlated with atherosclerosis, and HDL cholesterol, which is protective. However, the measurement of these fractions in a subject does not permit accurate determination of the risk to the subject. Likewise the measurement of apo A-I and B has brought an improvement in determining the risk factor but is still insufficient. The clarification of new markers would allow better definition of the potential atherogenic risk to a given individual Lp A-I (lipoproteins containing apo A-I but not apo A-II) level is probably an important indicator. Similarly, Lp(a) level is certainly an atherogenic lipoprotein and the apo E phenotype modulates the development of atherosclerosis. All these new markers and others, in the future, will better define the risk for an asymptomatic subject, with regard of atherosclerosis and therefore help to prevent it.

Arteriosclerosis

[Changes in the level of various amino acids in leukemia].

The determination of blood amino-acids by column chromatography has been carried out on 53 patients, 17 with acute myeloid leukemia, 22 with chronic myeloid leukemia. A comparison was made with 25 normal subjects. These determination has shown a significant increase in glycin, cystin and a non significant increase of tryptophan. A positive relationship may exist between uricemia and content of glycin and glutamin, both amino-acids which are messengers of uric acid. A positive correlation has been found between glycin tryptophan and the number of myeloblasts.

Amino Acids