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Biomedical subjects

J Couper-Smartt

Publications and source records attributed to J Couper-Smartt.

7 recordsLinked to original sources
PubMed1978

Paradoxical effects in sleep and performance of two doses of chlorpromazine.

Twenty-four subjects were given placebo, 25 mg, and 75 mg of chlorpromazine on three separate occasions. Twelve subjects were treated in the morning and tested for performance during the day. Twelve other subjects received the drug treatments in the evening. Both groups had their EEG stages of sleep recorded during the subsequent night. The low dose of drug shortened the REM/non-REM cycle length in comparison to the high dose, and placebo values were intermediate. In performance tests, visual integration time was impaired by the high dose of the drug. Logical reasoning was slowed by the high dose of the drug in comparison to the low dose, with placebo values intermediate between the two.

Adult↗
PubMed1978

Chlorpromazine and serial reaction performance.

The effect of 25 mg or 75 mg of chlorpromazine on the serial reaction performance of 12 male human subjects was studied. Speed or number of correct responses was reduced by the high dose of chlorpromazine and errors of commission and omission were increased. The adverse effect of the drug upon speed appeared only at the end of the half-hour test. By contrast the adverse effect upon gaps and errors was apparent throughout the test and there was no interaction with test duration.

Administration, Oral↗
PubMed1977

Behavioural antagonism between chlorpromazine and noise in man.

The effects of 25 mg and 75 mg of chlorpromazine and of 95 dBA of white noise were studied separately and together in 12 male human subjects. Performance, analysed by signal detection theory, showed that both noise and chlorpromazine applied separately caused impairment in similar ways. Suspended judgements were reduced and negative decisions correspondingly increased at low levels of evidence. When applied together, chlorpromazine and noise cancelled out each other's adverse effects. It is concluded that chlorpromazine is a specific behavioural antagonist of the stressful effects of noise.

Arousal↗