A mathematical model was found that consistently described diverse pharmacokinetic data for a development compound from three pharmacokinetic studies in healthy volunteers and two efficacy and safety studies in patients. The model provided: quantification of demographic and random sources of pharmacokinetic variability; estimation of important pharmacokinetic parameters from sparse data; and explanation of observed patterns of pharmacokinetic response.

Adult↗

PubMedDate not supplied

Splenosis: an unusual cause of intraabdominal hemorrhage.

A 31-year-old female presented to the emergency department with an acute onset of severe abdominal pain. She developed hypovolemic shock from an intra-abdominal bleed. At laparotomy she was found to be bleeding from two areas of splenosis on the uterine ligament. The patient had sustained a ruptured spleen 22 years prior and had no symptomatology from her areas of splenosis. A short review of splenosis is presented.

Abdomen, Acute↗

PubMedDate not supplied

[A case of anemia with partial myeloblastosis associated with pulmonary and hematologic tuberculosis].

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Aged↗

PubMedDate not supplied

Finding solutions to support remote area nurses.

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Australia↗