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J Crequat

Publications and source records attributed to J Crequat.

10 recordsLinked to original sources
PubMed2006

French fetal biometry: reference equations and comparison with other charts.

OBJECTIVES: To construct new reference charts and equations for fetal biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC) and femur length (FL), using a large sample of fetuses examined at 15-40 weeks in France, and to compare them with previous references. METHODS: The study data were obtained over a continuous 1-year period from a population of pregnant women undergoing ultrasound examination. Excluded were those with a known abnormal karyotype or congenital malformation, multiple pregnancies, and those with no first-trimester dating based on crown-rump length. No fetuses were excluded on the basis of abnormal biometry or birth weight. For each measurement, separate regression models were fitted to estimate both the mean and the SD at each gestational age. RESULTS: Full biometric measurements were obtained for 19 647 fetuses. New charts and reference equations are reported for BPD, HC, AC and FL. Prediction intervals for the new reference charts were similar to those of previous ones, whereas there were some differences in predicted centiles. CONCLUSION: We present new French reference charts and equations for fetal biometry. They can be used easily to compute centiles and Z-scores to control the quality of biometric assessments and to evaluate their performance relative to other references.

Abdomen↗
PubMed1996

Transvaginal intratubal methotrexate treatment of ectopic pregnancy. Report of 100 cases.

Between November 1988 and December 1993, 100 patients with a common, unruptured ectopic pregnancy were treated with 1 mg/kg injection of intratubal methotrexate under transvaginal sonographic control. Patients were not excluded from this series on the basis of the size of the adnexal mass, the term of ectopic pregnancy or initial beta-human chorionic gonadotrophin (HCG) concentrations. Patients were excluded following uncertain diagnosis, signs of a ruptured ectopic pregnancy, or a significant haemoperitoneum on ultrasound scans. The mean age of the patients was 29.5 years (range 20-41). The mean gestational age and initial HCG concentration were 7.5 weeks (5-11) and 11,614 mIU/ml (192-105,000 respectively). Of the 100 patients, 22 (22%) had an ectopic pregnancy with active cardiac activity. Complete resolution was obtained in 78 out of these 100 ectopic pregnancies. Of these, 66 patients (85%) needed only one intratubal methotrexate injection, and 12 patients (15%) required a second i.m. methotrexate injection of 1 mg/kg. In this study, local treatment with one single intratubal methotrexate injection was successful in only 66% of patients. The mean resolution time for reduction of beta-HCG concentrations was 23.5 days (range 7-40). There was no statistically significant correlation between initial beta-HCG concentrations and outcomes after methotrexate treatment of ectopic pregnancy in our study. Where embryonal heart beats were observed, the success rate of the procedure was 40.9% (nine out of 22 cases). In the absence of cardiac activity, or when ultrasound examination showed no embryo, the success rate achieved was 84.6% (66 out of 78 cases) (P < 0.01). In all, 34 patients were considered to be incompletely cured after only one intratubal methotrexate injection: 12 patients required a second i.m. injection, a stagnation of beta-HCG concentrations was observed in 15 patients, abdominal pain occurred in six patients, and one patient suffered tubal rupture with haemoperitoneum. A total of 22 patients required secondary surgical management (salpingectomy). No biochemical or clinical side-effects of methotrexate treatment occurred. Tubal alteration ascribable to methotrexate injection occurred in one patient in our study. Out of 75 patients in this series who wished to conceive, 21 (28%) became pregnant within 1 year with the following outcomes: 11 pregnancies at term, three miscarriages, one induced abortion and six recurrent ectopic pregnancies (four occurred on the same side). Our findings suggest that treatment of common unruptured ectopic pregnancy without prior selection of patients, by a single intratubal methotrexate administration was associated with a 66% success rate. This was dependent only on the presence of embryonal heart beats and there was no correlation between the success rate and initial beta-HCG concentrations. Successful outcome after methotrexate administration for ectopic pregnancy could be perfected by way of an improved selection of patients based on inactive embryonal hearts and absence of a visualized embryo.

Adult↗
PubMed1994

[Ovarian hyperstimulation syndrome and thrombosis. Apropos of a case of thrombosis of the internal jugular vein. Review of the literature].

Thrombosis of the internal jugular vein was associated with a severe syndrome of ovarian hyperstimulation. After in vitro fertilization, a twin pregnancy was obtained in a 31-year-old patient with severe endometriosis. On the day of follicle collection, plasma oestradiol was 3050 mg/ml. Ten ovocytes were collected and 3 embryos were implanted. A syndrome of severe ovarian hyperstimulation (ascites, pleural effusion) developed 3 weeks later and symptomatic treatment was given. Phlebitis of the upper left limb was diagnosed at 9 weeks amenorrhoea and echo-Doppler confirmed the diagnosis of subclavian and internal jugular venous thrombosis. Search for a cause was negative excepting a frank drop in protein S activity to 35%. Post-partum assay and assay in family members confirmed that the deficiency was acquired during pregnancy. The clinical course was favourable with anticoagulant therapy (heparin, then low-molecular weight heparin). Intra-uterine death of one of the fetuses occurred at 21 weeks amenorrhoea and a 2,550 g girl was born by vaginal delivery at 36 weeks. The Apgar score at birth was 10/10. In a review of the literature on vascular events in fertilization, programmes showed that severe syndromes of ovarian hyperstimulation, endogenous hyperestrogenism, multiple pregnancy and predominance of upper limb are the most frequently observed criteria. We emphasize the importance of preventing these thromboembolic events with subcutaneous heparin during the first trimester of pregnancy followed by low-molecular weight heparin, particularly in patients with a history of thromboembolism and/or patients with severe ovarian hyperstimulation.

Adult↗
PubMed1994

[Ethnic predisposition of the severity of HELLP syndrome. Retrospective study of 12 cases including 5 during post-partum].

HELLP syndrome is characterized by association of haemolysis (H), elevated liver enzymes (EL), and low platelets (LP). From 1989 to 1991, we studied retrospectively 12 cases of HELLP syndrome cases that occurred during the third trimester for 7 cases and during post-partum for 5 cases. 83% of patients (10/12) were black people (African or Creole). The most frequent sign of HELLP syndrome during pre- and post-partum was epigastric or dorsal pain, present in 91% of the cases (11/12) and in all cases of preeclampsia. Aggressive treatment was always performed, leading to 12 births: 7 of the 12 children were hypotrophic for gestational age. There were no maternal or neonatal deaths. Post-partum HELLP syndrome occurred 28.8 hours (mean) after delivery. Whether HELLP syndrome occurred during pre- or post-partum, laboratory findings returned to normal levels after equivalent delays: platelets 57 hours, ASAT 68 hours and ALAT 65 hours.

Adult↗
PubMed1993

[Urodynamic ultrasonography in the management of urinary disorders in women].

The authors report the preliminary results of a study on the use of perineal sonography with a vaginal probe as a complement to urodynamic investigation, in patients with stress urinary incontinence or other urinary symptoms. This technique seems useful especially in stress urinary incontinence to precise the existence and the importance of bladder neck hypermobility, and in the evaluation of post-opérative outcome after surgical suspension of the bladder neck.

Female↗
PubMed1993

[Endocystic echography by laparoscopy. 6 preliminary cases].

The decision whether to ablate an ovarian cyst using the operating laparoscope depends on a whole bundle of clinical, biological, ultrasound and laparoscopic factors. But opening a uni or multi-locular fluid containing cyst and exploring its walls can leave the operator in doubt as to whether it is benign, malignant or a borderline lesion. Now it is possible to use 3 mm catheters carrying a rotary ultrasound transducer. When this sound is placed inside a cyst it is possible to study the walls topographically. Six preliminary cases are presented; the increased sensitivity of the pictures obtained by this miniaturised sound make it possible to improve ultrasound diagnosis.

Diagnosis, Differential↗
PubMed1983

[Does echography resolve the problem of diagnosis of extrauterine pregnancy at its onset?].

Incipient ectopic pregnancy is always difficult to diagnose. Hormonal assays confirm pregnancy, but in "high tubal risk" women the site of ovular implantation must be determined as early as possible and this, in theory, can be done by ultrasound examination. However pseudogestational images resembling incipient ectopic pregnancy may be misleading, and in the tubal context ultrasound scans must be interpreted with caution before embryonic echoes can be identified in the amniotic cavity.

Chorionic Gonadotropin↗