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Biomedical subjects

J Crifasi

Publications and source records attributed to J Crifasi.

5 recordsLinked to original sources
PubMed1997

The GCMS analysis of tranylcypromine (Parnate) in a suspected overdose.

A fatal overdose involving tranylcypromine (Parnate) where blood, urine and tissues were quantitated using a pentafluoroproprionic anhydride (PFPA) derivative and gas-chromatography/mass spectroscopy (GCMS). The samples were re-quantified over several weeks demonstrating a significant loss of drug in tissues but not blood or urine specimens. The urine was positive for methamphetamine which has been a suspected metabolite.

Adult↗
PubMed1996

Methamphetamine identification in four forensic cases.

Specimens that tested positive for amphetamines by immunoassay were confirmed by mass spectrometry. The absence of detectable d-amphetamine (limit of detection at 50 ng/mL) with a positive methamphetamine prompted further testing by chiral derivatization. This data demonstrates that d-amphetamine need not be present in methamphetamine positive cases.

Accidents, Traffic↗
PubMed1996

Traffic fatality related to the use of methylenedioxymethamphetamine.

A recent traffic fatality has been attributed to the use of the drug methylenedioxymethamphetamine (MDMA). The deceased was a 29-year-old white male with no known history of drug abuse. Toxicological analysis detected MDMA and metabolite methylenedioxyamphetamine (MDA) in the blood, urine, and vitreous humor specimens submitted for analysis. The concentrations of MDMA in clotted blood, sodium fluoride-potassium oxalate anticoagulated blood, vitreous humor, and urine were 2.32 mg/L, 2.14 mg/L, 1.11 mg/L, and 118.8 mg/L, respectively. The concentrations of the metabolite MDA were less than 0.25 mg/L in blood and vitreous, and 3.86 mg/L in the urine.

Accidents, Traffic↗
PubMedDate not supplied

Comparison of analytical methods in the determination of two venlafaxine fatalities.

Two venlafaxine (Effexor)-related deaths are reported with comparison of results from the analysis of specimens using capillary gas chromatography with a nitrogen-phosphorous detector (GC-NPD) and high-performance liquid chromatography (HPLC) using a UV-vis detector. Blood concentrations in Case 1 were 7.27 micrograms/mL venlafaxine and 5.03 micrograms/mL O-desmethylvenlafaxine, and Case 2 had 89.67 micrograms/mL venlafaxine with 3.44 micrograms/mL of the desmethyl metabolite. A comparison of analytical methods and specimen concentration is presented.

Adult↗