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Biomedical subjects

J Croce

Publications and source records attributed to J Croce.

14 recordsLinked to original sources
PubMed1990

[Hypersensitivity in patients with Hebra's prurigo caused by flea bite].

The authors present a study of hypersensitivity of patients with Hebra's prurigo (HP) to feleabites. Thirty six patients were studied. With the results obtained the following conclusions are held: 1. Among the probable responsible factors found in the history of patients with HP, the flea bite is the principal factor. 2. Almost all the patients with HP who were studied show hypersensitivity to flea bites. 3. With the flea bites on the patients with HP, one can observe the clinical and histopathology similarity of both the experimental and elementary lesions of the disease. 4. It was possible to show humoral antibodies in the serum of the patients with HP immunodiffusion technique to the 1:40 flea extract.

Adolescent↗
PubMed1988

[Immunology of tertiary pinta].

We've studied the immunological performed of twenty two natives Tikunas suffering from tertiary pinta. Among those, patients had been treated previously (two years earlier) which 2,400,000 IU of G benzathine penicillin, and twelve had no treatment. Both groups demonstrated an increment in the IgM synthesis (72.72%), IgG (50%), indicating the presence of strong antigenic stimuli. The great majority presenting a negative response revealed also a reduction in the cellular immune competence to at least two of the tests performed (92.3%), when were realized the PPD, DNCB and skin grafts tests.

Humans↗
PubMed1986

A multicentre double-blind group comparative trial of two dose levels of nedocromil sodium and placebo in the management of perennial extrinsic asthma.

The efficacy of nedocromil sodium 4 mg or 2 mg q.i.d. in the management of perennial extrinsic asthma was evaluated in a double-blind, placebo-controlled, multicentre trial. Nedocromil sodium, especially at the dose of 4 mg q.i.d., was consistently rated higher than placebo on clinical assessment and diary card measurement. Compared with placebo, there were significant improvements for nedocromil sodium (4 X 4 mg) in asthma severity scores (p less than 0.05 after 1 and 2 weeks of treatment) and clinician's opinion of treatment (p less than 0.001). The results suggest that nedocromil sodium is effective in the maintenance treatment of patients with perennial extrinsic asthma and further studies with longer-term treatment periods are suggested.

Adolescent↗
PubMedDate not supplied

Bronchial challenge with aspirin lysine in the diagnosis of asthmatics with sensitization to aspirin and its inhibition by aerosolized furosemide.

We performed bronchial challenge with ASA lysine in 9 patients with a history of aspirin-induced asthma, 4 asthmatics with no history of hypersensitization to aspirin and 4 control subjects. The test consisted of successive inhalations of increasing concentrations of ASA lysine (11.25, 22.5, 45, 90, 180 and 360 mg/ml) and was interrupted when FEV1 showed a decrease of at least 20%. In order to determine the degree of bronchial hyperreactivity, we first carried out a bronchial challenge with histamine. All patients in the group sensitive to aspirin had a positive reaction to ASA lysine, while this was negative for patients in the two control groups. There was no significant correlation between PC20 to histamine and ASA lysine in any of the groups. On the other hand, 6 patients with sensitivity to ASA repeated the bronchial challenge with ASA lysine after previously inhaling furosemide, and in this second test, none of the 6 had a positive reaction. The variation of ASA lysine PC20 in both tests was positive for these patients (p < 0.001).

Adolescent↗
PubMedDate not supplied

[Atopic dermatitis].

Explore the source record for details and available documents.

Allergens↗
PubMedDate not supplied

Urticarial vasculitis.

Thirty seven patients with chronic urticaria were prospectively studied from August 1984 to July 1986. These patients were submitted to regular and immunological laboratory tests. Biopsies were taken from recent urticarial lesions for histologic analysis and also to direct immunofluorescence and immunohistochemistry studies. Vasculitis was found in 27% of the patients. Most of them showed only urticarial lesions except two (20%), that presented residual macula; angioedema occurred in 20% of the urticarial vasculitis (UV) patients; most cases had no systemic manifestations. Serum immunoglobulins and circulant immunocomplexes were increased in both groups. Complement reduction was considered an evidence of vascular aggression, being found in 55% of the UV patients. Direct immunofluorescence studies showed only 10% of positive IgM fluorescence in the vessel walls in the UV group. Immunohistochemical evaluation in the same group revealed mainly slight deposition of immunoglobulins IgG, IgM and IgA in the plasma cells of 80% of the samples and in only 10% there was immunoglobulin deposition in the vessel walls. The authors concluded that conventional histopathology is the best diagnosis method for urticarial vasculitis, direct immunofluorescence and immunoperoxidase being ancillary tools. Therefore, a special group of patients was detected, clinically and therapeutically resembling common urticaria patients, but presenting vasculitis in the histologic exam. This fact leads to the hypothesis that there is a range between common urticaria and urticarial vasculitis with systemic involvement.

Adult↗
PubMedDate not supplied

Cutaneous positivity in patients with respiratory allergies to 42 allergenic extracts of airborne fungi isolated in São Paulo, Brazil.

With the purpose of measuring the frequency of allergies of the respiratory tract to airborne fungi in São Paulo, Brazil, 201 patients with bronchial asthma and/or allergic rhinitis were submitted to intradermal testings with allergenic extracts of 42 fungus genera isolated from the air in São Paulo. The extracts of these fungi were prepared according to Coca's method and then standardized by the weight by the volume method. At first, the patients were submitted to intradermal testing with the total polyvalent (TP) extract, getting positive reaction in 70 of them (34.8%). The patients with positive reaction to the TP were tested with the 42 individual extracts and 74.3% of them reacted positively to one or more extracts. These results led us to the conclusion that the most frequent fungi in the air of São Paulo were not the ones which cause the highest number of positive intradermal reactions. Therefore, the convenience in employing as many allergens as possible in intradermal testings for diagnosis should be reinforced.

Air Microbiology↗
PubMedDate not supplied

[Forced mid-expiratory flow rate (FEF 25-75%): a critical analysis of its value in recognizing diseases of the small airways].

A total of 245 patients submitted to lung function test were studied. They were divided in 2 groups: A--FEV1.0/FVC greater than or equal to 75% and B--FEF25-75% less than 75%. These groups were further subdivided according to the age of the patients--subgroup 1 less than or equal to 50 years and subgroup 2 greater than 50 years. Patients with restrictive disorders were not included. The spirometric equipment employed was Hewlett-Packard Inc. Pulmonary Function Analyzer 47402-A. The results were obtained through a digital system and calculated from a graph impressed in a xy register. Results were automatically corrected to BTPS. In each group FVC and FEV1.0 were normal. In group A FVC and FEV1.0 were, respectively: A1-99.63 +/- 13.33 and 101.11 +/- 12.24, A2-97.60 +/- 11.06 and 98.81 +/- 12.18, expressed as percentage of predicted values. In group B the results were: B1-97.61 +/- 13.55% and 81.71 +/- 14.44%; B2-100.28 +/- 13.98% and 83.10 +/- 16.42%. The differences were not statistically significant at 5%. In subgroup A1 X FEV1.0/CVF was 83.41 +/- 5.63% and in subgroup A2, 79.42 +/- 4.23%. Maximum mid-expiratory flow rate was 88.64 +/- 24.39% in subgroup A1 and 65.26 +/- 17.88% in subgroup A2. These differences were statistically significant at 1%. In group B, FEV1.0/FVC was always less than 75%. In subgroup B1 it was 68.24 +/- 10.43% and in B2, 64.90 +/- 10.43% and values for FEF25-75% were 48.13 +/- 16.48% and 42.79 +/- 17.68%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Study of humoral and cellular immunity in lobomycosis.

Fourteen patients with lobomycosis from the Amazon Basin were studied in order to assess their humoral and cellular immunological responses. The humoral response was normal, as shown by the normal levels of serum immunoglovulins. The cellular immunity was depressed for recent sensitizations as measured by skin contact test with DNCB (negative in 83.3% of 12 patients). The intradermal reactions to PPD and fungal extracts suggested that all patients were able to respond to at least 2 of the antigens used. It was also observed that patients reacting to PPD did not become sensitized to DNCB. Conversely, some Mantoux negative patients had positive reactions to DNCB. Both tests were negative in 3 patients.

Antibody Formation↗
PubMedDate not supplied

Systematic isolation of the genus Alternaria in the atmosphere of the "Grande Sao Paulo" area (Brazil).

The genus Alternaria has been isolated from the atmosphere of several countries and its spores are considered as having a strong allergenic power. The description of the genus isolation with a relative frequency was noted in the following countries: Mexico, the United States of America, Canada, Great Britain, Spain, South Africa, Denmark and Argentina. Many Brazilian authors have pointed out the rare incidence of this genus excluding Faria (5) who recorded in the city of Belo Horizonte, State of Minas Gerais, a frequency of 21.1%. Several authors have failed to detect Alternaria sp. spores in the atmosphere of the city of Sao Paulo. As we were studying in our laboratory the airborne fungi of a region called Greater Sao Paulo, where the collections were made in some boroughs of the main city and its neighborhood, we began to make findings of the Alternaria sp. This gave us the opportunity of studying its incidence in that area during a period of one year. We chose 11 areas of this region where we made weekly plate expositions performing 429 trials in all. The technique of collection was the usual one with the exposition of the Petri dishes containing Sabouraud Agar distributed 72 hours before. The collection was made from September 1973 to August 1974. The exposition period was of 5 minutes duration in the open air or in a protected place when it rained. The exposition height was 1 meter from the ground. The identification was made through the colony macroscopic morphology and through the Riddell technique. The Alternaria sp. was isolated in the mentioned area through all the months of the year with its highest frequency in August (35.8%) and its lowest in December 3.7%). The average relative frequency obtained was of 17%. The highest isolation frequency was attained in Winter, the lowest in Spring; in Summer and Autumn, it remained at a medium level. In relation to the studied areas, the Alternaria sp. was isolated in all of them with a minimum frequency of 8.3% in Campos Eliseos and with a maximum frequency of 28.9% in Osasco. The authors would like to emphasize this unusual finding because in the region studied the Alternaria sp. was previously considered absent.

Air Microbiology↗