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Biomedical subjects

J Crossland

Publications and source records attributed to J Crossland.

At least 19 recordsLinked to original sources

Nursery rhymes, phonological skills and reading.

Nursery rhymes are an almost universal part of young English-speaking children's lives. We have already established that there are strong links between children's early knowledge of nursery rhymes at 3;3 and their developing phonological skills over the next year and a quarter. Since such skills are known to be related to children's success in learning to read, this result suggests the hypothesis that acquaintance with nursery rhymes might also affect children's reading. We now report longitudinal data from a group of 64 children from the age of 3;4 to 6;3 which support this hypothesis. There is a strong relation between early knowledge of nursery rhymes and success in reading and spelling over the next three years even after differences in social background, I.Q and the children's phonological skills at the start of the project are taken into account. This raises the question of how nursery rhymes have such an effect. Our answer is that knowledge of nursery rhymes enhances children's phonological sensitivity which in turn helps them to learn to read. This paper presents further analyses which support the idea of this path from nursery rhymes to reading. Nursery rhymes are related to the child's subsequent sensitivity to rhyme and phonemes. Moreover the connection between knowledge of nursery rhymes and reading and spelling ability disappears when controls are made for differences in these subsequent phonological skills.

Achievement↗

The dimensions of positive emotions.

This study was designed to investigate the dimensionality of positive emotions and was run in two parts. In part 1, subjects were given a set of 24 different life-situations all of which commonly give rise to positive emotions. They sorted the 24 situations into groups on the basis of whether or not they produced similar emotional responses. In part 2 of the study subjects rated each of the 24 situations on 13 emotion scales. The grouping data obtained in part 1 were submitted to multidimensional scaling (MDS) and returned a four-dimensional solution. Canonical correlations between the four MDS dimensions and the 13 emotion scales revealed that dimension 1 is best explained by 'absorption', dimension 2 by 'potency', dimension 3 by 'altruistic' and dimension 4 by 'spiritual'. These correlations were then married to an interpretation of the situations falling high and low on each of the four dimensions, with the following results. Dimension 1 distinguishes internal or private situations from social situations, dimension 2, achievement from leisure situations, dimension 3, social demands from self-indulgence, and dimension 4, serious from trivial situations. The implications of these findings for the study of emotion are discussed.

Achievement↗

Location and identification of the collagen found in the 14.5-d rat embryo visceral yolk sac.

The collagens associated with 14.5-d rat visceral yolk sacs were localized and identified by a variety of procedures. Morphological examination showed that both the visceral epithelium and mesothelium rested upon thin basement membranes, whereas the majority of the extracellular matrix consisted of a stroma containing occasional cells and abundant banded fibrils. Immunohistochemistry at the electron microscope level showed that the basement membranes specifically cross-reacted with antibodies directed against mouse basement membrane components, whereas the stroma specifically cross-reacted with antibodies directed against rat type I collagen. Extractions of acellular visceral yolk sacs and subsequent analyses showed that type I collagen components were prevalent. Furthermore, in vitro biosynthetic studies showed only the presence of type I procollagen components (or their conversion products) and alpha-fetoprotein. These findings, taken together with our previous studies on the 14.5-d rat parietal yolk sac, provide us with protein markers for studying the origin of cells in rat parietovisceral yolk sac carcinomas.

Animals↗

The production of morphine tolerance and physical dependence by the oral route in the rat. A comparative study.

A method for the chronical administration of morphine by the oral route is discussed and compared with the production of physical dependence to morphine by injection. The method recommends the administration of Morphine HCl dissolved in a 45% sucrose syrup and given orally for 4 weeks. The initial concentration of morphine in the syrup was 1 mg/ml and was increased weekly up to 4 mg/ml at the end of the experiment. This procedure rendered the animals physically dependent on morphine as observed by drug withdrawal, when abstinence symptoms were easily identified.

Administration, Oral↗