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Biomedical subjects

J Cuypers

Publications and source records attributed to J Cuypers.

6 recordsLinked to original sources
PubMed1979

Therapy of cluster headache with histamine H1 and H2 receptor antagonists.

Treatment with the histamine H2 receptor antagonist, cimetidine, alone and/or in combination with the histamine H1 receptor antagonist, chlorpyramine, in 13 patients showed that cimetidine alone was ineffective. 7 of 9 patients taking the combination of H1 and H2 receptor antagonists responded well to the treatment; in 1 patient, medication was ineffective and in 1 patient, success was doubtful. In 3 patients with chronic cluster headache, the effect faded after 4 weeks. The results are discussed.

Cimetidine↗
PubMed1978

Effect of indomethacin on CO2-induced hyperaemia (CO2-response) in the rabbit brain.

It was studied in rabbits whether indomethacin, a prostaglandin-synthesis inhibitor, influences cerebral hyperaemia induced by inhalation of carbon dioxide (CO2-response). The aim of this experiment was to show whether prostaglandins are involved in the regulation of cerebral vascular tone. The animals were repeatedly ventilated with a CO2-room air mixture before and after the injection of indomethacin solution. Regional cerebral blood flow in one hemisphere was continously measured using a thermo-clearance method. In 10 out of 13 rabbits no effect of indomethacin on the CO2 response could be observed. In the other 3 animals a reduction of the CO2-response only occurred in the 15-45 minutes interval after the indomethacin injection. The authors, however, do not exclude the possibility of this reduction being an artefact. The reasons are discussed.

Animals↗
PubMed1976

Effect of central venous pressure on brain tissue pressure and brain volume.

In cats, brain tissue pressure (BTP) was measured by the wick-catheter method. The BTP was positive, but lower than cerebrospinal fluid pressure. Elevation on central venous pressure led only to a transient proportional increase of BTP. When the calvaria and dura of one hemisphere were removed, the rise of BTP was even less. Water content of the brain was normal in either case, even after prolonged venous hypertension. Venous hypertension led in all cases to a marked increase of the brain volume which was caused by vessel dilatation. In brain edema, produced by rinsing the brain surface with ouabain and concentrated saline, BTP was increased permanently by venous hypertension. The water content of the brain was much greater than normal. From these results it was concluded that congestive edema does not occur in the brain unless the tissue is damaged. However, venous hypertension does cause brain swelling.

Animals↗
PubMed1975

Effect of systemic arterial blood pressure on cerebral blood flow in intracranial hypertension.

In five baboons and 11 cats cerebral ischaemia was produced either by inflating an epidural balloon and or by ligating major arteries supplying the brain. Fifteen of the animals developed intracranial hypertension after cerebral ischaemia. If ICP were high, but still significantly lower than MABP, elevation of MABP by noradrenaline infusions was accompanied by a proportional increase of ICP. However, the increase of ICP was lower than that of MABP so that CPP was raised. CBF measured by the 133Xenon clearance technique was significantly increased by arterial hypertension in eight cases. The proportional increase of CPP and CBF by elevation of arterial blood pressure was substantially greater, the lower ICP was immediately after ischaemia. There was no effect of MABP in cases in which ICP equalled MABP.

Animals↗