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Biomedical subjects

J Czigner

Publications and source records attributed to J Czigner.

33 records · Page 2Linked to original sources
PubMed1994

[Primary CO2 laser chordectomy in vocal cord carcinoma].

A study was performed with laryngo-microscopic CO2 laser surgery on 55 patients suffering from histologically verified glottic cancer. They were treated by either "superficial laser chordectomy", or "partial cordectomy", "total chordectomy", or "extended chordectomy" in stages Tis = 7, T1a = 34, T1b = 11, and T2 = 3. All patients with Tis remained free of tumours, in stage T1a 88% (30/34) of the patients after laser chordectomy and 2 patients after partial- and total laryngectomy. In stage T1b the recurrence rate was higher (3/11 = 27%), but 2 patients after partial laryngectomy, and one patient after radiotherapy have become tumour-free, and thus all patients in this group are free from tumours. One of the 3 patients in stage T2 developed a local tumour recurrence, but after partial laryngectomy he is free from tumour and hence all 3 patients are still alive. Laser chordectomy proved a sufficient therapeutic procedure in 47 (85%) of 55 patients; eventually 95% of the patients became tumour-free. The authors emphasise that CO2 laser chordectomy is a modern and useful surgical method in the therapy of a vocal cord carcinoma, provided adequate follow-up and the possibility of "salvage" surgery are available.

Adult↗
PubMed1993

Lack of short-term autoregulation in the cochlear microcirculation in guinea pigs.

To determine the relationship between the dynamics of mean arterial blood pressure (MABP) elevation and possible changes in the cochlear microcirculation the cochlear blood flow (CBF) was measured in guinea pigs by a laser Doppler method. The MABP was elevated at rates ranging from 0.02 mmHg/s to 4 mmHg/s by intravenous infusions of norepinephrine or epinephrine in various concentrations. A fall in MABP was induced by exsanguination of the animals. The purpose of the experiments was to record the time of onset and course of an expected autoregulation in the cochlea in response to slow or rapid changes in MABP. The data suggest that there is no short-term autoregulation in the cochlear microcirculation reflecting the increase of the MABP, but a slight compensation occurs when the MABP declines. These latter changes could be attributed to the high CO2 sensitivity of the cochlear blood vessels.

Animals↗
PubMed1993

[Function preserving laryngeal cancer surgery in Hungary-- a historical retrospect and 25 years personal experiences].

The continuity in the trends in conservation and surgery in the Hungarian laryngology are emphasized. The first Hungarian book on this topic, "Diseases of the Larynx" by Navratil, was published 127 years ago ("A gégebajok", Pest, 1866). Onodi popularized the laryngectomy and the results of the surgery of laryngeal carcinoma in the first two decades. In 1900, Herczel described on a vertical partial laryngectomy. Lénárt was an internationally accepted Hungarian surgeon in laryngology whose results (cordectomy 61%, partial laryngectomy 48%, hemilaryngectomy 42%, total laryngectomy 35%) were consistently successful. Réthi was a famous name in the recent period of Hungarian laryngeal surgery for laryngotracheal stenosis and laryngeal carcinoma. In the past 25 years, the occurrence of supraglottic cancer was the highest. The author reports his personal results and stresses the importance of conservation surgery. Of a total of 643 patients with supraglottic carcinoma, 126 (20%) were treated by primary radiotherapy, 169 (26%) were operated on by total laryngectomy, 245 (38%) by supraglottic laryngectomy, 61 (9.5%) by supraglottic subtotal laryngectomy (personal method) and 42 (6.5%) by resection of the supraglottic larynx and the base of the tongue. Local tumour control was constantly good with a local recurrence rate of 6.6%. The 5-year survival rate was 74.3% for supraglottic laryngectomy, 68.9% for subtotal laryngectomy and 62% for the resection of the supraglottic larynx and the base of the tongue group.

Combined Modality Therapy↗
PubMed1988

The barrier-like role of activated connective tissue against the spread of supraglottic laryngeal carcinoma.

Light microscopic investigations of whole organ serial sections of 15 laryngectomy specimens with supraglottic carcinomas and comparative electron microscopic studies of the upper and lower poles of the tumors were carried out. The ultrastructure of different poles of the same supraglottic tumors was investigated and showed a more progressive fibrillogenesis with an activation of the connective tissue elements of the border on the lower pole of the malignancy. A significant role is attributed to the barrier-forming feature of activated connective tissue with respect to the inhibition of the extension of tumor into the glottic region.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Reconstruction of spinal accessory nerve after radical neck dissection.

Resection of the spinal accessory nerve in cases of radical neck dissection often causes considerable damage to the function of the shoulder girdle; it leads to limitation of the motion of the upper limb and pain in the shoulder girdle. It seems a sensible compromise to reconstruct the spinal accessory nerve in one-stage operation with radical neck dissection, which can often prevent extensive atrophy of the trapezius muscle, with a resultant improvement in the chance of successful rehabilitation. The technique of the operation is described: after completion of radical neck dissection, in one-stage operation an autogenous nerve transplant from the n. auricularis magnus is sewn onto the central and peripheral stumps of the spinal accessory nerve, which are protected by a "vein-muff" and the fascia of the muscle. After such spinal accessory nerve reconstruction, subjective complaints and objective symptoms were much milder in 6 patients than in the control group, which consisted of 10 patients who underwent a similar operation but without spinal accessory nerve reconstruction.

Accessory Nerve↗
PubMedDate not supplied

Laser lingual tonsillotomy.

The classic surgical procedures for treatment of complaints caused by hyperplasia and chronic inflammation of the lingual tonsil are difficult, and may involve serious complications. Eleven patients with hyperplasia of the lingual tonsil were treated with a Tungsram TLS 61 CO2 laser coupled to an operating microscope. The average duration of hospitalization was 3-4 days. The advantages of the use of a CO2 laser are haemostasis, sealing of the nerve endings, decrease of postoperative pain, and no postoperative oedema, which is important because of the closeness of the larynx. There were no serious complications either during surgery or in the postoperative period, and the complaints of all 11 patients were eliminated or reduced.

Adult↗