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J D Acton

Publications and source records attributed to J D Acton.

10 recordsLinked to original sources

Baumann's confusing legacy.

Dr Ernst Baumann has been credited with describing an angle that can be measured from radiographs taken of children's elbows. This article presents three variations in the definition of this angle that we found in the orthopaedic literature. Variation I is the angle between the long axis of the humerus and a line through the physis of the lateral condyle of the distal humerus. Variation II is the angle between the perpendicular to the long axis of the humerus and a line through the physis of the lateral condyle. Variation III is the angle between the line through the physis of the lateral condyle and a line connecting a point on the edge of the trochlea to a point at the lateral limit of the physis of the lateral condyle. By reading translations of two of Baumann's own articles, we have realised that he used variation I when assessing the radiographs. He did, however, believe that the reciprocal angle, variation II equalled the carrying angle of the elbow and this can be demonstrated by Fig. 1, which has been taken from an article that was published in 1929. The relationship between this angle and the carrying angle has since been proven to be more complex than Baumann believed. We recommend that a descriptive term such as the 'shaft-physeal' angle would cause less confusion and variation in the definition of this angle.

Child↗

Phenotype of CF and the effects of possible modifier genes.

Cystic fibrosis is an inherited multi-system disease, characterised by progressive lung disease and pancreatic insufficiency that is classically attributed to the dysfunction of a single gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). The widely diverse phenotypic expression of CF is likely influenced by other genetic traits separate from the CFTR locus or modifier genes. Many of the genes currently under study as potential modifiers of CF, particularly those which influence the severity of lung disease, are involved in the control of infection, immunity and inflammation. Some of these include HLA class II antigens, mannose-binding lectin, alpha(1)-antitrypsin and alpha(1)-antichymotrypsin, glutathione-S-transferase, nitric oxide synthase type I, TNF-alpha, TGF-beta, IL-1beta and IL-1Ra.

Cystic Fibrosis↗

Effect of interferon on polymerization of single-stranded and double-stranded mengovirus ribonucleic acid.

Gordon, Irving (University of Southern California, Los Angeles), Sara S. Chenault, Douglas Stevenson, and Jean D. Acton. Effect of interferon on polymerization of single-stranded and double-stranded mengovirus ribonucleic acid. J. Bacteriol. 91:1230-1238. 1966.-The effect of interferon on actinomycin-resistant mengovirus ribonucleic acid (RNA) replication in L cells was investigated to determine whether defective or partially polymerized RNA products were made and whether synthesis of any specific class of virus RNA was prevented. RNA labeled with uridine-C(14) was extracted in hot and cold phenol and analyzed by zonal sucrose density centrifugation. Both single- and double-stranded infectious RNA peaks were identified. Interferon treatment caused almost complete depression of uridine-C(14) incorporation throughout linear sucrose gradients except in the 4S region, and no infectivity was detectable in any fraction. These inhibitory effects are attributable to the action of interferon, because they were reversed when cultures were treated with actinomycin D simultaneously with interferon. The results, with those of other investigators, indicate that the step at which interferon interrupts virus multiplication is between the events immediately after uncoating and the formation of template "minus" strands; under the conditions of our experiments, no partially polymerized virus RNA products were made.

Carbon Isotopes↗

Production of interferon by alveolar macrophages.

Acton, Jean D. (Bowman Gray School of Medicine, Winston-Salem, N.C.), and Quentin N. Myrvik. Production of interferon by alveolar macrophages. J. Bacteriol. 91:2300-2304. 1966.-Rabbit alveolar macrophages inoculated with parainfluenza-3 virus in vitro produce a viral inhibitor which possesses the properties of interferon. The interferon is nondialyzable, is stable at pH 4, is not sedimented at 100,000 x g, exhibits species specificity, and can passively protect other alveolar macrophages from infection with virulent rabbitpox virus. The possible significance of alveolar macrophage-produced interferon is discussed.

Animals↗