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Biomedical subjects

J D Bailey

Publications and source records attributed to J D Bailey.

At least 37 records · Page 2Linked to original sources
PubMed1983

Maturation of lung function in children with hypopituitarism.

To identify factors that bring about maturation of the respiratory system, we studied pulmonary function in 18 patients 9 to 19 yr of age with severe growth retardation caused by hypopituitarism. In 6 we measured pulmonary pressure-volume (P-V) curves before and after a 4 to 6 yr period of human growth-hormone-induced catch-up growth. Even when size-corrected according to total lung capacity (TLC), all measurements were more appropriate for height than for age. The ratio of functional residual capacity to TLC was low for age (less than 2 SD in 8 of 18 patients), and the ratio of closing capacity to TLC was slightly high for age (108% of predicted, p less than 0.05). The diffusion constant for carbon monoxide and the slope of the nitrogen washout alveolar plateau were both high for age. Lung elastic recoil was low for age; Pst(L) at 60% TLC was less than 2 SD in 3 of the 6 patients studied. During the period of catch-up growth, TLC increased appropriately for height, the slope of the alveolar plateau decreased (1.9 to 1.0% N2 L, p less than 0.01) and Pst(L) at 60% TLC increased (6.3 to 7.9 cm H2O, p less than 0.02). The P-V results indicate that growth of the lungs per se causes the increase in lung elastic recoil previously observed during childhood.

Adolescent↗
PubMed1980

A pituitary abscess simulating an intrasellar tumor.

A 16-year-old girl presented with amenorrhea, polyuria, and thirst for eight months and severe headaches for two weeks. An intrasellar mass protruding above the sella turcica was demonstrated by pneumoencephalography. When the tumor was approached surgically by a transsphenoidal route, it was found that the sella turcica contained encapsulated purulent material under pressure. Ampicillin and methicillin had been given preoperatively, and postoperatively she required hormonal replacement therapy for anterior and posterior pituitary hypofunction.

Adenoma↗
PubMed1978

The superior-mesenteric-artery syndrome: cause or complication of anorexia nervosa?

The so-called superior-mesenteric-artery syndrome is not mentioned in psychiatric journals or books. Yet two variations of the condition have been described. In its acute form, it can be mistaken for psychogenic vomiting in anorexic patients, while its chronic intermittent form is readily misdiagnosed as anorexia nervosa. The case report is of a 16 year old boy admitted for investigation and treatment of severe weight loss. He initially responded to a modified behaviour program, but within days developed an acute small-bowel obstruction. Superior-mesenteric-artery syndrome was diagnosed and he improved with appropriate medical management. This condition needs to be considered by the psychiatrist who otherwise might not differentiate it from the symptoms of anorexia nervosa.

Adolescent↗
PubMed1976

Clinical and physiological assessment of asthmatic children treated with beclomethasone dipropionate.

Forty-two perennial asthmatic children were selected for a 12-wk study using beclomethasone dipropionate. The groups included 21 steroid-dependent children (Group I) and 21 patients (Group II) whose disease was of sufficient severity that corticosteroid therapy was contemplated. All children received the drug in a dose of 100 mug 4 times daily. During the study, oral prednisone was withdrawn from the steroid-dependent children while other therapy was essentially unchanged. Group II children underwent a double-blind trial, receiving beclomethasone for 6 wk and placebo for 6 wk. Objective assessment of adrenal and pulmonary function was obtained at regular intervals. For the latter, total lung capacity and its subdivisions, airways resistance, maximum expiratory flow volume, and oxygen tension, were measured in both groups. In Group II static elastic recoil was measured also. For most tests the results were statistically significant. In both groups, 18 of 21 patients demonstrated an excellent clinical response, no evidence of adrenal suppression, and improvement in pulmonary function. Forty of 42 patients were followed for another 12 wk, and 19 of each group did well. After 20-24 wk of therapy, 16% of patients harbored monilia in their oropharynx, and 1 patient had clinical monilial stomatitis. Within the limits of the time of the study, beclomethasone dipropionate appeared to provide adequate clinical control in many chronic, severe, steroid-dependent and nonsteroid-dependent asthmatic children.

17-Ketosteroids↗
PubMed1975

Medical Research Council of Canada therapeutic trial of human growth hormone: first 5 years of therapy.

The Medical Research Council of Canada has initiated human growth hormone (hGH) therapy in 151 patients with documented complete hGH deficiency that was idiopathic in 76% of cases, secondary to craniopharyngioma (organic) in 17% and of varied cause in 7%. Approximately 50% of the patients with idiopathic disease had isolated hGH deficiency; during therapy thyroid deficiency developed in five patients and cortisol deficiency in three. A similar increase in mean height velocity occurred in the first treatment phase for patients less than 12 years old (0.93 plus or minus 0.30 cm/mo) and those 12 years and older (0.86 plus or minus 0.29 cm/mo). Although subsequent courses of hGH therapy yielded significantly diminished response in both age groups, this diminution was not progressive: the height velocity of the younger patients returned to 0.82 plus or minus 0.26 cm/ml in the fifth therapy phase. The mean height velocity attained at the optimal dosage (0.20 to 0.29 units/kg three times per week) for each age group did not differ significantly. Despite therapy being carried out for only 6 months of the year, normal increment ratios for height age and bone age against chronologic age were observed in the patients with idiopathic disease. In only four patients did treatment failure occur, and three of these were more than 20 years old. The addition of fluoxymesterone (10 mg/d) to the hGH therapeutic regimen (15 units/wk), when diminished response to hGH alone became evident, promoted an enhanced growth response in 9 of 11 older patients. These data indicate that age of the patient and dosage of hGH, but not diagnostic category, were important influences on the response to therapy. Younger patients responded best and maintained a higher mean growth velocity than older patients during intermittent hGH therapy

Adolescent↗
PubMed1973

Congenital varicella associated with multiple defects.

Only two previous reports in the medical literature record the association of multiple congenital defects in the baby and varicella in the mother during the first trimester of pregnancy.The case is reported of a female infant born to a mother who contracted varicella in the 11th week of pregnancy. The infant was premature, small for dates, and had skin and localized muscular defects and respiratory difficulty. Subsequently she was found to be retarded. She failed to thrive and was subject to frequent infections. Further investigation revealed a unilateral diaphragmatic weakness, scoliosis and abnormalities of the ocular fundi. Several non-febrile seizures occurred. A pneumoencephalogram revealed dilated ventricles. She died at 20 months of age following a seizure.Consideration of maternal infections, especially viral, occurring early in pregnancy, augmented by antibody studies in the newborn and mother should be part of the investigation of multiple congenital defects in the newborn.

Abnormalities, Multiple↗