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Biomedical subjects

J D Bogden

Publications and source records attributed to J D Bogden.

67 records · Page 4Linked to original sources
PubMed1975

Extraction of lead from printed matter at physiological values of pH.

In an in vitro laboratory study of the extractability of lead in printed matter it was found that dangerous quantities of lead, up to 200 mug, could be extracted from "small" pieces of printed paper at pH values in the range of human gastric fluid. Lead was not extracted at pH values in the range of human saliva. Children who chew printed matter may not be in danger of absorbing lead, but the pica-prone child who swallows printed material may be at risk of absorbing excessive amounts of this toxic metal. The use of printing inks containing high-lead levels should be discouraged.

Color↗
PubMed1975

Distribution of thallium and lead in children's blood.

Mean whole blood concentrations for lead and thallium were determined by atomic absorption spectrophotometric analysis for children residing in Newkark, NJ. Frequency distributions for the various concentration ranges for both metals were recorded. There is no noticeable correlation between the lead and thallium content of whole blood, which suggests that exposure to and/or absorption of these substances are different.

Child, Preschool↗
PubMedDate not supplied

Lead acetate does not impair secretion of Sertoli cell function marker proteins in the adult Sprague Dawley rat.

This study was conducted to determine the effects of lead on Sertoli cell function. Androgen binding protein and inhibin in testicular fluids and classical parameters of the hypothalamic-pituitary-gonadal axis were measured in adult male rats. For 10 wk, the rats were given water that contained 0.05%, 0.1%, 0.5%, and 1% lead acetate. Serum follicle-stimulating hormone, luteinizing hormone, and testosterone levels in all animals that ingested lead were normal at the middle and end of the experiment, as was the pituitary content of follicle-stimulating hormone and luteinizing hormone. Histologic examination revealed no disruption of spermatogenesis. Distribution of androgen binding protein in serum, seminiferous tubular fluid, and interstitial fluid was normal, as was the concentration of inhibin in interstitial fluid and seminiferous tubular fluid. However, a significant increase in epididymal androgen binding protein level and a decrease in seminal vesicle weight were observed in rats that ingested water containing 1% lead acetate. These results suggest that the effect of lead on spermatogenesis is not marked in adult Sprague Dawley rats, nor does Sertoli cell function appear to be affected adversely. Lead has been reported to alter in vitro metabolic function of Sertoli cells obtained from 16- to 21-d-old Sprague Dawley rats, and the Sertoli cells of juvenile animals may be more susceptible to lead than those of adult animals. The significant decrease in seminal vesicle weight and the abnormal epididymal androgen binding protein content indicate that lead could affect the male reproductive function in Sprague Dawley rats via its action on male accessory organs.

Androgen-Binding Protein↗
PubMedDate not supplied

Extraction of copper and zinc from rubber and silicone stoppers.

Drugs and other chemicals are often administered in the drinking water of laboratory animals, and bottles for this purpose usually have rubber stoppers. We studied the ability of solutions of several drugs to extract copper and zinc from rubber and silicone stoppers. Water and isoniazid extracted little copper or zinc from rubber stoppers, whereas EDTA, ethambutol, tetracycline, and chlorpromazine generally extracted considerable quantities of copper and zinc from these stoppers. Neither water nor solutions of the above drugs extracted copper or zinc from silicone stoppers. We routinely use silicone stoppers on water bottles when conducting laboratory studies requiring administration of drugs, toxins, or nutrients in the drinking water.

Copper↗
PubMedDate not supplied

Cadmium effect on the Na,K-ATPase system in cultured vascular smooth muscle cells.

The present study focuses on the interaction between cadmium (Cd) and the Na, K-ATPase system in in vitro grown vascular smooth muscle cells (VSMCs) derived from the rat carotid artery. In disrupted VSMCs rendered permeable by osmotic shock, Cd inhibited Na, K-ATPase; I50 was reached at 10(-5) M Cd. Mg-ATPase was also inhibited by Cd; I50 was attained at concentrations of 10(-4) M Cd. Cd inhibition of Na,K-ATPase in the VSMCs was noncompetitive with respect to Na, K, and ATP. Rubidium transport experiments performed with intact VSMCs demonstrated that within an incubation period of 150 minutes, a concentration of 10(-4) M Cd in the extracellular fluid exerted no acute effect on the Na-K pump. Within this time interval, intracellular Cd attained a concentration eightfold higher than the extracellular Cd concentration. Thus, it appears that under acute conditions Cd exerts its inhibitory effect on Na, K-ATPase only in disrupted VSMCs. The data further suggest that, in the VSMC, conditions under which Cd inhibits Na, K-ATPase are consistent with inhibition from the cytoplasmic side of the cell membrane.

Animals↗