Sarcoidosis presenting as Heerfordt's syndrome with myopathy.
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Adult↗
Biomedical subjects
J D Fratkin
Publications and source records attributed to J D Fratkin.
Toxicity of chronic spinal analgesia in a canine model: neuropathologic observations with dezocine lactate.
The chronic spinal toxicity of dezocine lactate was investigated in mongrel dogs. Dogs received chronic intrathecal infusion from implanted infusion pumps for 28-136 days. Infusion of saline via intrathecal catheters produced leptomeningeal fibrosis, sometimes with spinal cord compression. Dezocine lactate infusion, in addition to similar leptomeningeal changes, was also associated with severe parenchymal lesions in all cases. The exact cause of this toxicity cannot be specifically assigned; potential contributing factors include catheter-induced reaction, pH of the drug, lactate concentration, osmolality and the pharmacologic agent itself. Leptomeningeal reaction in control dogs limits the value of chronic intrathecal dog models for assessment of spinal drug toxicity.
Analgesics, Opioid↗
Localization of glial fibrillary acidic protein in retinal astrocytoma: an immunohistochemical study.
Glial fibrillary acidic protein (GFA) is found in glial filaments, and is specific for reactive or neoplastic astrocytes and ependyma. Using a commercially available antibody to GFA protein, a retinal neoplasm from a patient with neurofibromatosis is intensely stained with the brown immunoperoxidase reaction product. Rather than the less specific phosphotungstic acid hematoxylin (PTAH) or Holzer's stain, antibody to GFAP protein is a relatively rapid, simple, and reliable immunohistochemical technique for formalin-fixed and paraffin-embedded tissue.
Astrocytoma↗