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Biomedical subjects

J D GRAHAM

Publications and source records attributed to J D GRAHAM.

At least 19 recordsLinked to original sources
PubMed1964

DISTRIBUTION OF (2-BROMOETHYL)ETHYL(NAPHTH-1-YMETHYL-(14C))AMINE HYDROBROMIDE IN THE RAT.

(2-Bromoethyl)ethyl(naphth-1-ylmethyl)amine hydrobromide (SY28) is a halogenoalkylamine related to dibenamine. A dose of 10 mg/kg injected intravenously into rats antagonizes the pressor response to adrenaline for 36 hr. If this amount of SY28 labelled with (14)C in the 1-methyl position is administered, specific radioactivity is present in blood and tissues many days after the antagonism of adrenaline is relieved. The (14)C is excreted in bile and in urine, but not in expired air. It is present in fat but not to a greater extent than it is in other tissues. It does not cross the placental barrier. There is no evidence that slow release from a lipid depot accounts for the long duration of action.

Adipose Tissue↗
PubMed1961

The effect of reserpine on the pressor response to injection of 2-halogenoethylamines.

Dibenamine-like compounds sometimes caused an increase in blood pressure when injected intravenously in mammals. This response varied with species, with the preparation, and with the structure of the compound. The response became smaller after repeated injections. In spinal atropinized rats injected with hexamethonium 5 mg/kg this pressor effect produced by injection of the adrenaline antagonist, compound AT3 [ethylfluoren-9-yl(2-iodoethyl)amine hydriodide], was reduced by prior treatment for five days with 1 mg/kg reserpine. Acute adrenalectomy also reduced this effect of the adrenaline antagonist; reserpine plus adrenalectomy abolished it. Subsequent injection of adrenaline and noradrenaline restored it.

Adrenalectomy↗
PubMed1959

Distribution of [14C] bemegride in tissues after intravenous injection.

The distribution and excretion of bemegride labelled at the alpha carbon atoms with (14)C were studied in mice, rats, and guinea-pigs. These studies were supplemented by others made by colorimetric and absorptiometric methods on unlabelled bemegride in the body fluids of rabbits and dogs. Bemegride passed rapidly from plasma to all tissues, including brain, muscle, and fat. In addition it passed readily into the cerebrospinal fluid and the aqueous humour and to the foetus. It persisted in the tissues for longer than 24 hr., to some extent preferentially in the central nervous system. Approximately two-thirds of the dose was excreted in the bile, faeces, and urine within 24 hr. The glutarimide ring of bemegride was not completely degraded biologically.

Animals↗
PubMed1959

Cough suppressants.

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Antitussive Agents↗