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J D Gradon

Publications and source records attributed to J D Gradon.

27 records · Page 2Linked to original sources

Massive hepatic enlargement with fatty change associated with ketoconazole.

Several forms of hepatic toxicity have been described with the antifungal agent ketoconazole. We report a case of massive liver enlargement with fatty infiltration presenting as gastric compression. This occurred in a young woman with AIDS taking ketoconazole as maintenance therapy for cryptococcal meningitis. This is the first reported case of ketoconazole causing fatty change in the liver.

Adult

Severe hypomagnesemia associated with pentamidine therapy.

A case of severe hypomagnesemia in a patient with AIDS that manifested as changes in mental status is presented. The hypomagnesemia was due to renal wasting of magnesium, most probably caused by pentamidine-induced renal tubular injury. This entity has been reported once before and should be considered in the differential diagnosis of altered mental status in patients with AIDS.

Acquired Immunodeficiency Syndrome