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Biomedical subjects

J D Griffiths

Publications and source records attributed to J D Griffiths.

At least 37 records · Page 2Linked to original sources
PubMed1983

Klinefelter's syndrome associated with breast carcinoma and Paget's disease of the nipple.

We describe a patient with Klinefelter's syndrome associated with multi-focal breast carcinoma and Paget's disease of the nipple. Reviewing the 16 previously documented cases in the world literature, it is apparent that patients with this syndrome have an increased incidence of breast carcinoma. There is no evidence to date to suggest that such tumour is morphologically or biologically different from breast cancer in females and normal men.

Adenocarcinoma↗
PubMed1982

Colon transposition in the management of upper gastrointestinal cancer.

Restoration of swallowing after the resection of malignant disease in the upper gastrointestinal tract, including the pharynx, remains a surgical challenge. Recontructive techniques using a viscus are reviewed and 40 consecutive cases treated at the Royal Marsden Hospital (1965-1980) by colon transposition are reported. The major indication for this procedure was postradiation relapse of pharyngolaryngeal cancer requiring pharyngolaryngectomy. In 60% of the cases, a long-segment colon transposition was carried out through a retrosternal tunnel. The presternal subcutaneous route was used in one third of the cases and the posterior mediastinum in 7%. The 30-day operative mortality was 20% overall, but in recent years it was lowered to 7%. The major complications were cervical fistula (25%) and bronchopneumonia (20%), which frequently occurred together in patients who had undergone prior radiation therapy. Colon necrosis occurred in two cases. The functional outcome was satisfactory, with good results in 78%. Late structures due to marginal arteritis were observed if further radiation therapy was used in the cervical region. Where follow-up data was available, the mean survival was 36 months (range, 2-180; median 18 months) and the three-year survival rate was 32%. Colon transposition must remain an alternative to gastric transposition and is a durable esophageal substitute for long-term palliation.

Adult↗
PubMed1976

Fibrinolytic activity of carcinoma of the colorectum.

Twenty patients with carcinoma, mostly of the colorectum, and five without malignant tumors who were used as controls, have been investigated to elucidate the relationship between tumor fibrinolytic activity and the release of circulating malignant cells. The nature of the tumor fibrinolytic activity has been considered. The most significant fibrinolytic activity was seen in blood draining from the tumors and was evident in 80 per cent. Circulating malignant cells were recovered from half the patients, and in those with significant blood fibrinolysis, recovery from the draining vein reached 89 per cent. The most undifferentiated tumors appeared to be more active and released more cells. Fibrinolytic activity of tumor tissue derives from inflammatory cells, dead tumor cells, avascular areas of the tumor and vascular endothelium and is probably proteolytic as well as purely fibrinolytic.

Colonic Neoplasms↗
PubMed1972

Uptake of gallium-67 in colonic and rectal tumours.

The uptake of (67)Ga in biopsy specimens of normal and abnormal tissue was measured in 20 cases of colonic and rectal disease and the ratio between the (67)Ga uptake in these diseases and in the normal colon or rectum was determined. Uptake of the isotope was high in most of the 14 primary malignant tumours, being highest in poorly differentiated tumours. This uptake was found to be concentrated at the active tumour edge. Uptake of the isotope was generally low in non-malignant lesions.

Biopsy↗