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Biomedical subjects

J D Haines

Publications and source records attributed to J D Haines.

At least 19 recordsLinked to original sources
PubMed2005

Developmental partitioning of myelin basic protein into membrane microdomains.

Specific membrane microdomains (including lipid rafts) exist in myelin but have not been fully characterized. Myelin basic protein (MBP) maintains the compactness of the myelin sheath and is highly posttranslationally modified. Thus, it has been suggested that MBP might also have other functions, e.g., in signal transduction. Here, the distribution of MBP and its modified forms was studied, spatially and temporally, by detailed characterization of membrane microdomains from developing and mature bovine myelin. Myelin membranes were extracted with three different detergents (Brij 96V, CHAPS, or Triton X-100) at 4 degrees C. The detergent-resistant membranes (DRMs), representing coalesced lipid rafts, were isolated as low-buoyant-density fractions on a sucrose density gradient. These myelin rafts were disrupted when cholesterol was depleted with methyl-beta-cyclodextrin. The use of CHAPS detergent led to enrichment of several myelin proteins, including phospho-Thr97-MBP, in the DRMs from mature myelin. Citrullinated and methylated MBP remained in "nonraft" microdomains. In contrast, the DRMs from early myelin were enriched in Golli-MBP, Fyn, Lyn, and CNP. The localization of various proteins in DRMs was further supported by the colocalization of these lipid raft components in cultured mouse oligodendrocytes. Thus, there is a developmental regulation of posttranslationally modified forms of MBP into specific membrane microdomains.

Animals↗
PubMed2005

A case of pseudoseizures.

Pseudoseizures, historically described as hysterical seizures, closely resemble epileptic attacks. However, they lack the abnormal paroxysmal electrical discharges from the brain seen in epilepsy. Pseudoseizures may represent a dissociative coping mechanism in which anxiety is reduced by the appearance of the pseudoseizure. Psychotherapy is the mainstay of treatment for pseudoseizures.

Adaptation, Psychological↗
PubMed2000

Medical response to bioterrorism: are we prepared?

The 1995 bombing of the Federal Building in Oklahoma City made terrorism a shocking reality for all Oklahomans. The fact that such an event could happen here, far from foreign political and ethnic conflicts and from large coastal cities, made us realize that no one is immune from the terrorist threat. But as horrific as that event and other terrorist incidents have been, the present threat of the use of infectious agents in acts of terrorism has the potential to cause far greater human death and suffering than any previously used terrorist weapon. Although health care professionals have not historically participated in terrorist planning and response activities, the addition of infectious agents to the terrorists' arsenal makes medical and public health professionals critical players in these efforts. Indeed, physicians have the ability to first recognize and report such an event and thereby diminish the impact. To meet the bioterrorism responsibility, physicians must be knowledgeable of this type of threat. In this article we present an overview of bioterrorism and review the organisms most likely to be used in a terrorist event.

Biological Warfare↗
PubMed1998

Herbal healers.

Explore the source record for details and available documents.

Aged↗
PubMed1996

Mismanaged care.

Explore the source record for details and available documents.

Humans↗
PubMed1994

Treatment of arrow wounds in the American Indian-Fighting Army: the technique of Brevet Lt. Col. Joseph H. Bill.

The history of medicine contains many chapters with seemingly insoluble problems that were overcome by great innovators. Contributors like Pasteur, Reed, and Salk altered the practice of medicine forever. However, along with the giants of medicine, there have been legions of other physicians who have made lesser, but not unimportant contributions. Many of these discoveries involved techniques that became obsolete as technology progressed, and many others formed the basis for further medical advances. Such was the case of Dr. Joseph H. Bill's technique of treating arrow wounds in the Indian Fighting Army of 1866-1890.

Foreign Bodies↗
PubMed1991

Wheezing as a sign of foreign-body aspiration in infants and children.

Airway obstruction from aspiration of a foreign body should be suspected in all infants and children who have swallowing or respiratory difficulties. If the patient is unable to clear the airway by coughing, the Heimlich maneuver should be attempted. Parents can help to prevent airway obstruction by keeping small objects away from infants and children and by teaching them to chew food thoroughly.

Airway Obstruction↗
PubMed1991

Sassafras tea and diaphoresis.

A patient whose main symptom is sweating can present a diagnostic challenge. Dr Haines describes a case in which diaphoresis was caused not by a conventional medication or illness but rather by a life-style change in which the patient began consuming sassafras tea.

Aged↗