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Biomedical subjects

J D Herrlinger

Publications and source records attributed to J D Herrlinger.

34 records · Page 2Linked to original sources
PubMed1975

[Anaphylactic shock following multiple injection of a multienzyme compound (author's transl)].

An anaphylactic shock after multiple injections of the multienzyme compound Neoblastine with the clinical signs of unconsciousness, tachycardia and marked depression of vascular system is reported. Specific antibodies (double diffusion method; 1:32) and an increasing eosinophilia of the peripheral blood up to 36 rel. % have been demonstrated. It must be warned of the application of this compound, the indication of which is extremely doubtful.

Adult↗
PubMedDate not supplied

[Hyperostosis of the sterno-clavicular joint - an enthesopathy?].

Erosion of the insertions of tendons and ligaments in bone (i.e. of the enthesis) due to chronic aseptic inflammation causes reparative ossification. With regard to our clinical and radiological findings in ten patients hyperostosis of the sterno-clavicular joint seems to be the late stage of such an enthesopathy. Pain and swelling of the soft tissues and an elevated erythrocyte sedimentation rate are characteristics of this seronegative rheumatic disease. For visualizing the extraarticular changes in the sterno-costo-clavicular region tomography is necessary. Early diagnosis and consequent antiphlogistic therapy should remit pain and help avoid hyperostosis.

Adult↗
PubMedDate not supplied

[Effect of D-penicillamine and 2-mercaptoethanol on human IgM in normal serum].

Serum from healthy blood donors (O Rh+) was fractionated on a Sephadex-G-200 column before and after incubation with equal volumes of either 0.2 m 2-Mercaptoethanol or D-Penicillamine. Immunoelectrophoretic analyses revealed that addition of these two sulphhydryl-containing compounds resulted in disappearance of the typical IgM-precipitate within the first peak. A new precipitate specific for M-chains appeared within the second peak. The data indicate that the smaller subunits with M-chain specificity result from splitting of disulphide bonds of the IgM molecules by the D-Penicillamine and the 2-Mercaptoethanol.

Blood↗
PubMedDate not supplied

Oral gold therapy with auranofin (SK&F 39162). A multicenter open study in patients with rheumatoid arthritis.

One hundred and fifty patients with rheumatoid arthritis received 6 mg of auranofin daily for 2-24 months. Thirty patients were withdrawn from the study, and 82 patients were observed for 12 months. Statistical evaluation was available for 74 patients at weeks 24, 38, and 48, respectively. The major side effects observed were diarrhea, rash, and alopecia. Significant improvement was noted in the articular index, ESR, pain, and morning stiffness.

Administration, Oral↗
PubMedDate not supplied

Distribution of gold in serum erythrocytes and white blood cells after in vitro incubation and during chrysotherapy with different gold compounds.

We examined the binding of gold to serum proteins and the gold level in serum and in blood cells both after incubation in vitro and under longterm treatment with 3 gold compounds. Gold was measured by atomic absorption spectrophotometry, a serum fractionated by gel chromatography; blood cells were separated by gradient centrifugation, and intracellular gold was measured after pressure decomposition and MIBK-extraction. Aurothiomalate (GSTM), gold keratinate (GK), and auranofin (AF) were used. AF showed the highest binding to globulins in in vitro and in vivo. With GSTM and GK there were no measurable amounts of gold in the red cell lysate or erythrocyte membranes whereas with AF 40% of gold was localized within erythrocytes. The amount of gold in granulocytes and mononuclear cells after incubation with AF is considerably higher than with GK and GSTM.

Auranofin↗
PubMedDate not supplied

[Protein binding of gold in serum of patients treated with different gold preparations].

Binding of gold to serum proteins of patients treated with Na-aurothiomalate (AM), gold keratinate (GK) and triethylphosphine gold (PG) was compared. In addition the pattern of distribution of gold in serum of healthy donors after in vitro incubation with these compounds and with tetrachlorogoldacid (GC) was studied. Serum specimens were fractionated by gel filtration (Sephadex G 200), gold was measured by atomic absorption spectroscopy, concentration of protein was calculated by extinction at 280 nm. After incubation with AM, PG and GC in vitro gold binds to serumproteins rapidly and completely (concentration of gold with AM and GC about 5 mg/l, with PG about 1 mg/1). The distribution among the protein fractions is different, however. With AM and GC 94% of gold is bound to albumin and only 6% to globulin. The corresponding figures with PG are 70% respectively 30%. With GK gold binds not completely to serum proteins in vitro. Even after 24 hours incubation about 7% are unbound. The affinity to globulin is high with GK (20%). On principle the pattern of distribution of gold is the same in vivo. The concentration of gold in the serum was almost the same as during the in vitro experiments. No unbound gold was found with GK. The affinity to globulin increases from AM to GK and especially to PG. The reason for these typical patterns are at least in part different metabolic pathways of the gold compounds. These findings may explain some differences of efficacy of certain goldcompounds.

Anti-Inflammatory Agents↗
PubMedDate not supplied

[Yersinia arthritis. Long-term follow up].

Twenty-two patients were followed for a mean of 10.7 years after acute Yersinia arthritis. Their clinical course, agglutinating antibodies, and laboratory parameters of inflammation were analyzed. In 73% of cases HLA-B27 was positive. The acute disease lasted from 1 month to 1 year. One male patient showed a bilateral synostosis of sacroiliac joints at the acute phase of the disease. He developed the clinical characteristics of severe ankylosing spondylitis. Another two patients with HLA-B27 had radiologically inflammatory changes of sacroiliac joints or symphysis without clinical findings. Agglutinating antibodies against dead Yersinia bacilli were negative in all patients. No laboratory signs of inflammation were present. The long-term prognosis of Yersinia arthritis is benign.

Adolescent↗