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Biomedical subjects

J D Hobday

Publications and source records attributed to J D Hobday.

At least 19 recordsLinked to original sources
PubMed1987

In vitro synthesis of IgE by human peripheral blood leucocytes: V. Functional heterogeneity within the IgE-B-cell pool.

Fractionation of human peripheral blood leucocytes (PBL) B cells by differential sedimentation on a discontinuous Percoll gradient separates B cell subpopulations which vary markedly in rates of spontaneous IgE synthesis, often revealing the presence of active IgE secreting cells which are totally suppressed within unfractionated PBL B cell preparations. The production in vitro of IgE by separated B cell populations from the same individual may respond disparately to an identical population of autologous T cells and to pokeweed mitogen. Kinetic studies revealed major differences in both the rates of release of cell-associated IgE between these B cell populations, and their rates of de novo IgE synthesis. From a methodological viewpoint, the use of this B cell fractionation technique is demonstrated to improve greatly the efficiency of detection of T cell-responsive IgE producing B cells in peripheral blood from atopics, and from a mechanistic standpoint raises the possibility that B cell heterogeneity may modulate the functional expression of IgE-regulatory T cells signals.

Adult↗
PubMed1986

Congenital renal salt-losing syndrome and failure to thrive in infancy.

An infant with congenital renal salt-losing syndrome is reported. The importance of recognizing this rare disorder is emphasized because early detection, and treatment with sodium supplementation, results in marked growth improvement and may prevent volume depletion, electrolyte disturbance, and cardiovascular collapse. The clinical features and biochemical abnormalities seen in the congenital renal salt-losing syndrome are described. In this condition, natriuresis occurs in the face of normal renal and adrenal function and, as the child gets older, spontaneous resolution occurs. Other causes of hyponatraemia in infancy are discussed.

Adult↗
PubMed1985

In vitro synthesis of IgE by human peripheral blood leucocytes. IV. Longitudinal study of regulatory T-cell activity in atopics.

The assessment of IgE production in cultures of T- and B-cells from peripheral blood is proving a useful tool to probe IgE immunoregulation in human atopics. The present study contrasts secretion and synthesis as indices of IgE production, and demonstrates that these measures yield comparable data upon the magnitude and direction of regulatory T-cell effects (help vs. suppression) in severe atopics. The majority of peripheral blood B-cell samples from the atopics in this study exhibited spontaneous IgE synthesis and secretion, and in vitro T-cell help and suppression were observed with equal frequency within the sample population. Repeated testing of individual atopics indicated that the direction of T-cell effects remained stable in some (but not all) atopics over periods as long as 3 years.

Adolescent↗
PubMed1978

Treatment of asthma in children.

Children present a special problem, as the morbidity from asthma is high. Deaths occasionally occur. Evaluation of frequency and severity is mandatory in designing therapy. Adequate theophylline dosage is an effective bronchodilator. Nebulized salbutamol is a great advantage in moderate and moderately severe asthma because of its speed, ease of administration and effectiveness. Intravenous salbutamol is a considerable advance in the treatment of severe asthma. The use of nebulized Intal makes this drug available to the younger child for prophylaxis. Effective prophylactic long term management must include an environmental evaluation including detection of allergens and, if possible their removal, and the evaluation of physical pulmonary trigger factors and attention to emotional physical health.

Albuterol↗