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Biomedical subjects

J D Loeser

Publications and source records attributed to J D Loeser.

At least 19 recordsLinked to original sources
PubMed1992

A case of opiate-insensitive pain: malignant treatment of benign pain.

OBJECTIVE: We report the case of a woman with presumed cancer pain treated with escalating doses of opiates despite no evident improvement in her pain and several deleterious side effects. PATIENT: A 62-year-old woman with cervical myelopathy and a diagnosis of a spinal cord tumor was referred to the University of Washington Medical Center complaining of chest tightness, multiple joint pains, nausea, constipation, seizures and a deteriorating memory. At the time of admission she was confined to her bed with a full-time attendant and was receiving 240 milligrams of intravenous morphine per hour for her pain. INTERVENTION: Diagnostic studies failed to find any evidence of neoplasm and revealed only an old hemorrhage within the cervical spinal cord. A program of increasing physical and occupational therapy and decreasing opiate intake was initiated. RESULTS: Within a month the patient's pain complaints decreased, as did the rest of her presenting complaints. Her activities of daily living greatly increased making attendant care no longer necessary. CONCLUSIONS: This case report illustrates some of the hazards of opioid therapy in the management of patients with chronic pain. Our patient's opiate therapy was expensive, gave her undesirable side effects, and did not reduce her pain complaints or improve her function. In the treatment of chronic pain, of noncancerous or cancerous origin, a) systemic opioids may not be effective in reducing pain complaints in every patient, b) treatment efficacy evaluation should always include functional endpoints, and c) nonefficacious treatments should not be continued indefinitely.

Chronic Disease↗
PubMed1992

Small area analysis of surgery for low-back pain.

Rates of spine surgery (discectomy, laminectomy, fusion) vary several-fold among "small areas" such as counties or hospital market areas. To ascertain why this is so, an analysis was conducted of variability in rates among counties in the State of Washington (N = 39). Since, unlike previous published reports, this study excluded patients with cancer, major trauma, and infection, as well as those with cervical and thoracic procedures, rates in this study pertain specifically to the problem of low-back pain. Six classes of variables to explain variability among county rates were defined: I) percentage of the labor force in heavy labor and transportation occupations; II) socioeconomic conditions; III) neurologic and orthopedic surgeon density; IV) occupancy rate of back surgery hospitals; V) primary payer and VI) health care availability. In all, the effect of 28 explanatory variables was tested. In doing so, the authors took into account the possibility of spurious correlation. The rate of surgery for low-back pain varied nearly 15-fold among counties. The explanatory variables that were tested, however, accounted for only a minor part of the variability. The hypothesis that "physician practice style factor" accounts for the major part is explored; potential properties of practice style factor are specified for further testing.

Back Pain↗
PubMed1992

Use of the International Classification of Diseases (ICD-9-CM) to identify hospitalizations for mechanical low back problems in administrative databases.

Large administrative databases are increasingly valuable tools for health care research. Although increased access to these databases provides valuable opportunities to study health care utilization, costs and outcomes and valid and comparable results require explicit and consistent analytic methods. Algorithms for identifying surgical and nonsurgical hospitalizations for "mechanical" low back problems in automated databases are described. Sixty-six ICD-9-CM diagnosis and 15 procedure codes that could be applied to patients with mechanical low back problems were identified. Twenty-seven diagnosis and two procedure codes identify hospitalizations for problems definitely in the lumbar or lumbosacral region. Exclusion criteria were developed to eliminate nonmechanical causes of low back pain, such as malignancies, infections, and major trauma. The use of the algorithms is illustrated using national hospital discharge data.

Algorithms↗
PubMed1992

The diagnosis of disability. Treating and rating disability in a pain clinic.

Medical diagnosis sanctions illness and directs physicians toward effective treatment. In chronic illness, these two functions of diagnosis can come into conflict. Nowhere is this conflict more striking than in the case of disability ratings for those with chronic pain. An institutional case study examining the relation between a pain clinic and a worker's compensation program is presented and analyzed in terms of two questions: (1) Is it ethical for one physician to both treat pain and rate disability in patients with chronic pain? (2) Is physician rating of disability due to pain scientifically valid? Ethical and conceptual analyses support a negative response to each of these questions. The roots of the ethical and scientific problems concerning disability ratings are identified in society's demand to differentiate medical and nonmedical distress. We propose a system of time-limited compensation for pain as a therapeutically superior alternative to disability ratings.

Attitude of Health Personnel↗
PubMed1992

Morbidity and mortality in association with operations on the lumbar spine. The influence of age, diagnosis, and procedure.

We examined the rates of postoperative complications and mortality, as recorded in a hospital discharge registry for the State of Washington for the years 1986 through 1988, for patients who had had an operation on the lumbar spine. When patients who had had a malignant lesion, infection, or fracture are excluded, there were 18,122 hospitalizations for procedures on the lumbar spine, 84 per cent of which involved a herniated disc or spinal stenosis. The rates of morbidity and mortality during hospitalization, as well as the hospital charges, increased with the ages of the patients. The rate of complications was 18 per cent for patients who were seventy-five years or older. Nearly 7 per cent of patients who were seventy-five years old or more were discharged to nursing homes. Complications were most frequent among patients who had spinal stenosis, but multivariate analysis suggested that the complications associated with procedures for this condition were primarily related to the patient's age and the type of procedure. Complications, length of hospitalization, and charges were higher for patients who had had a spinal arthrodesis than for those who had not. Over-all, operations for conditions other than a herniated disc were associated with more complications and greater use of resources, particularly when arthrodesis was performed, than were operations for removal of a herniated disc. No data on symptoms or functional results were available.

Adolescent↗
PubMed1991

Pediatric intracranial pressure monitoring in hypoxic and nonhypoxic brain injury.

We reviewed the results of all pediatric patients undergoing intracranial pressure (ICP) monitoring in a 2-year period at our institution. The outcome of patients suffering hypoxia or ischemic injuries (HII) is compared to those suffering non-hypoxic or non-ischemic injuries (NHII). Thirty-four patients had ICP monitors placed during the study period. Incomplete patient information led to the exclusion of 5 patients. An additional 5 patients were excluded because no measures to control ICP were taken after the monitor was placed. Twenty-four patients required treatment for raised ICP (hyperventilation, 24; mannitol, 19; barbiturate coma, 6). Admission Glasgow Coma Score in patients suffering HII (median score 5) and NHII (median score 6) were not significantly different (Mann-Whitney U Test). Only 2 of 8 patients with HII were near-drowning victims. The remaining 6 had HII from other causes (5 survivors of various forms of asphyxia and 1 of cardiac arrest). All 8 patients had poor outcomes (1 severely disabled; 7 died). The 16 patients with NHII had a variety of diagnoses (6 trauma, 5 encephalitis, 4 bacterial meningitis, 1 diabetic ketoacidosis). Among these, 6 had good outcomes and 10 poor outcomes (2 severely disabled, 2 vegetative, and 6 died). The difference in outcome between patients with NHII and HII is significant at P = 0.059 (Fischer Exact test). Patients with NHII may benefit from ICP monitoring. Patients with HII from near-drowning and other causes did not appear to benefit from ICP monitoring and interventions directed at controlling ICP.

Adolescent↗
PubMed1991

What is chronic pain?

Chronic pain leads to individual suffering and to major costs for all developed countries. Previous studies suggest that both the incidence of disabling chronic pain and the amount of health care consumption due to chronic pain are rapidly increasing. Western medicine is not only often ineffective but may be one of the causes of this epidemic. This article will address the issue of chronic pain of unknown etiology and has the goals of: (1) identifying the factors which have led to our confusion about this topic, and (2) proposing alternative ways of conceptualizing chronic pain and its ensuing behaviors and social consequences. It is concluded that it is essential to discriminate between tissue damage, pain, suffering, pain behaviors, health care consumption, impairment and disability if one is to develop a meaningful conceptualization of the medical, social, economic and political problems of chronic pain. Successful treatment must be defined in behavioral terms such as restoration of normal activities. Disabling chronic pain is often a sign of overwhelming stress engendered by the individual's failure to cope with the demands of industrialized society.

Activities of Daily Living↗
PubMed1991

Back sprain in industry. The role of socioeconomic factors in chronicity.

A minority of industrial-back-sprain claimants account for most of the cost of industrial back sprain: those whose disability persists into "chronicity", which is defined as 90 days or more off work. The data in this study demonstrate the effects of socioeconomic factors on chronicity. This analysis is based on State of Washington industrial insurance claims for back sprain. For both men and women, three socioeconomic factors significantly affect the risk of chronicity: age, wage, and the family status of being either widowed or divorced with no children. In addition, the Nam-Powers Socioeconomic Index is significant for men. Wage compensation ratio cannot be shown to be a factor in chronicity.

Adult↗
PubMed1991

Epidemiology of low back pain.

The science of epidemiology is difficult to apply to the problem of low back pain. This article discusses the problems associated with the study of low back pain, population surveys, risk factors for low back pain, and disability because of low back pain.

Back Pain↗
PubMed1991

Theories of back pain and health care utilization.

Because most people in the United States have occasional back pain, demand for the treatment of back pain is widespread. Yet, few treatments have proven to be more effective than placebo therapy. We examine patterns of treatment that have emerged in the absence of definitive treatment. We concentrate on high-cost users of back pain treatment (i.e., chronic pain patients) and high-cost treatments (i.e., surgical and non-surgical hospitalization for low back pain). The small minority of back pain patients whose disability persists into chronicity (90 days or more) accounts for a disproportionate amount of all back pain costs. Interventions have been developed to prevent back pain but, once back pain has already occurred, little is done to prevent it from becoming chronic. Drug therapy may be used to treat the symptom of chronic pain, the cause of which may not be thereby affected. Regarding high-cost treatments, surgical and nonsurgical hospitalizations for low back pain are common practices in the United States. Pain specialists for the past 15 years have advocated a conservative approach to back pain, but the rate of surgery for low back pain increased during this time. Average lengths of stay for surgical and nonsurgical low back pain hospitalizations decreased. We explore why, in the instance of low back pain surgery, change was resisted, whereas, in the instance of average lengths of stay, change was accepted. In view of why change may be resisted or accepted, we discuss interventions designed to change physicians' practice style.

Back Pain↗
PubMed1990

Contemporary pain management.

Pain management is a dynamic clinical area. Basic research is generating new drugs and new technologies for their delivery. Clinical research has demonstrated the important roles of psychological and environmental factors in the complaint of pain. Surgical strategies are improving. The recognition that the human brain plays a major role in pain perception and pain behaviours has led to the development of multidisciplinary teams that can bring a diversity of diagnostic and therapeutic skills to clinical medicine. The specialty of pain management is gaining momentum throughout the world. Australian health care delivery needs to respond to these developments to permit the citizens of this country to receive state-of-the-art care. Not only will this be more humane, but it will permit a reduction in the enormous financial costs of the poor management of both acute and chronic pain.

Acute Disease↗
PubMed1990

Herniated lumbar intervertebral disk.

Low back pain is common, but a herniated intervertebral disk is the cause in only a small percentage of cases. Most symptomatic disk herniations result in clinical manifestations (pain, reflex loss, muscle weakness) that resolve with conservative therapy, and only 5% to 10% of patients require surgery. Sciatica is usually the first clue to disk herniation, but sciatica may be mimicked by other disorders that cause radiating pain. Because more than 95% of lumbar disk herniations occur at the L4-5 or L5-S1 levels, the physical examination should focus on abnormalities of the L5 and S1 nerve roots. Plain radiography is not useful in diagnosing disk herniation, but more sophisticated imaging (myelography, computed tomography, or magnetic resonance imaging) should generally be delayed until a patient is clearly a surgical candidate. Conservative therapy includes nonsteroidal anti-inflammatory drugs, brief bed rest (often for less than 1 week), early progressive ambulation, and reassurance about a favorable prognosis. Muscle relaxants and narcotic analgesics have a limited role, and their use should be strictly time-limited. Conventional traction and corsets are probably ineffective. Except for patients with the cauda equina syndrome, surgery is generally appropriate only when there is a combination of definite disk herniation shown by imaging, a corresponding syndrome of sciatic pain, a corresponding neurologic deficit, and a failure to respond to 6 weeks of conservative therapy.

Back Pain↗
PubMed1990

Management and long-term follow-up review of children with lipomyelomeningocele, 1952-1987.

The medical records of patients at Children's Hospital and Medical Center treated for lipomyelomeningocele repair were reviewed to assess the long-term outcome of surgery. In total, 108 children were cared for between 1952 and 1987, and long-term data are available for 80 of 96 children who underwent surgery. Cutaneous manifestations and associated malformations were common. Surgical repair was performed at ages 1 week to 17 years; there was no operative mortality. Thirty-five of 38 children with normal preoperative examination were without deficits on long-term follow-up review. Bowel and bladder paralysis was present in 42 children and did not recover after release of cord tethering. Eleven children had return of symptoms and were reexplored 3 to 8 years after initial surgery. Surgical repair with release of cord tethering at the time of diagnosis is advocated, regardless of patient age.

Adolescent↗
PubMed1988

Long-term efficacy of microvascular decompression in trigeminal neuralgia.

Forty patients were followed for an average period of 8 1/2 years after 44 consecutive suboccipital craniotomies for trigeminal neuralgia. Among these patients, 36 had microvascular decompression (MVD) of the nerve, four had repeat trigeminal rhizotomy after MVD was not successful in controlling their pain, and four had primary trigeminal rhizotomies. Of the 36 patients undergoing MVD, 17 (47%) experienced recurrent postoperative neuralgic pain: in 11 (31%) pain recurrence was major, and in six (17%) it was minor. Among the eight patients undergoing rhizotomy, four (50%) had major pain recurrences and one (13%) had a minor recurrence, for a 63% total recurrence rate. There was a strong statistical relationship between an operative finding of arterial cross-compression of the nerve and long-term complete pain relief. Patients with other compressive pathology (related to veins or bone structures) did not on the average fare as well. Despite this, there appeared to be no point in time in the postoperative interval when the patient could be considered "cured." Major recurrences averaged 3.5% annually, and minor recurrences averaged 1.5% annually. The implications of these findings for the treatment of trigeminal neuralgia and the current understanding of the mechanism of MVD for this disorder are discussed.

Arteries↗
PubMed1985

Pain due to nerve injury.

Some of the chronic pains that follow disc rupture, myelography, and discectomy may be due to injury to peripheral nerves or nerve roots. The neural mechanisms underlying these pain syndromes are discussed and possible etiologies examined. The roles of peripheral and central changes in neuronal activity and connectivity are explored: plasticity in the nervous system may either be the cause of pain in the 5% of people who develop chronic pain after nerve injury or what prevents pain in the 95% who do not become painful after nerve injury. More research on the behavior of damaged nerves and their central connections is essential.

Adult↗
PubMed1979

Subtotal neonatal calvariectomy. A radiographic and histological evaluation of calvarial and sutural redevelopment in rabbits.

A subtotal calvariectomy was performed on rabbits between 10 and14 days of age. The animals were allowed to grow and were then sacrificed serially so that the sutural and skeletal redevelopment could be analyzed through a combination of gross, radiographic, and histological techniques. The results indicate that calvarial regeneration is a progressive process with a definite pattern and rate of development. During the regenerative process, bone was deposited both at the surgical margin and as islands within the srugical defect. The eventual approximation of these areas of ossification produced multiple fibrous articulations. The majority of these articulations were obliterated by bone union, except for the midsagittal, coronal, and metopic sutures, which were re-established in their appropriate antomical positions. The maintenance of dural integrity during the surgical phase and the regeneration and establishment of pericranial continuity during the postoperative period were believed to be important in the re-establishment of normal sutural and skeletal architecture.

Animals↗
PubMed1978

What to do about tic douloureux.

Tic douloureux is a common disease that causes excruciating pain. It is a central pain due to a lesion within the trigeminal nerve or brain stem. The majority of patients with tic douloureux are successfully treated by pharmacotherapy with phenytoin or carbamazepine. Those who fail under medical management should promptly be offered modern surgical alleviation of their pain: percutaneous radiofrequency gangliolysis or decompression of the trigeminal nerve at the brain stem (Jannetta procedure). The goal of surgical therapy should be pain relief with minimal sensory loss; the complications of surgery are usually due to denervation of the face or eye. Patients with tic douloureux should not be subjected to extraneous drug therapy or other procedures with a low likelihood of long-term success.

Carbamazepine↗