Biomedical subjects

J D McQueen

Publications and source records attributed to J D McQueen.

At least 19 recordsLinked to original sources

PubMed1985

Parkinsonism as a manifestation of brain tumor.

Neoplasm is an uncommon cause of the parkinsonian syndrome. We are presenting three cases of intracranial tumors whose major manifestations included parkinsonism. Surgical treatment resulted in control of the extrapyramidal symptoms in two of our patients. Because no curative treatment is available for the vast majority of parkinsonian patients, early detection of an underlying neoplasm may offer a most rewarding outcome. Unilaterality of the symptoms, overwhelming dementia, or suspicion of a mass should lead to the performance of computed tomography.

Aged↗

PubMed1985

Primary intracranial chondrosarcoma: a report of two cases.

Two cases of primary intracranial chondrosarcoma are presented. The cases were similar in that they both arose from the temporal bone, contained both myxomatous tissue and material of cartilaginous consistency, and were avascular. Histological studies excluded the diagnosis of chondroid chordoma. A brief review of the subject is presented.

Aged↗

PubMed1978

Autoregulation of cerebral blood flow during alcohol infusion.

Vascular changes, in the absence of respiratory complications, were observed in monkeys and dogs after infusion of 20% ethanol solutions.

Angiotensin II↗

PubMed1978

Traumatic internal carotid occlusion at the base of the skull.

A case of traumatic thrombosis of the internal carotid artery at the base of the skull is reported, and 23 similar cases collected from the literature. This review shows that 85% of the patients either died or were left with major neurological deficit, and only 15% recovered completely. There were two primary sites for the onset of thrombosis. One in the petrous pyramid and usually associated with basal skull fracture, and the other immediately distal to the posterior communicating artery in patients with minor head trauma.

Adolescent↗

PubMed1976

Radiation-induced intracranial malignant fibrous histiocytoma.

An autopsy case of radiation-induced intracranial malignant fibrous histiocytoma (fibroxanthosarcoma) is reported. The tumor developed in the region of the sella turcica 11 years after high dose radiotherapy of a chromophobe adenoma of the pituitary. The tumor had infiltrated the base of the brain as well as the base of the skull. Metastases were not found. The tumor was composed of an admixture of bizarre fibroblasts, histiocytes and giant cells, xanthoma cells and siderophages, with a storiform fibrous stroma. This appears to be the first documented instance of a malignant fibrous histiocytoma occurring intracranially after local x-irradiation.

Adenoma, Chromophobe↗

PubMed1975

Symptomatic Rathke's cleft cyst with amyloid stroma.

A patient with panhypopituitarism and visual field defects due to a Rathke's cleft cyst is presented. These cysts are commonly found in random pituitaries examined at necropsy, but rarely produce symptoms. Subtle endocrine deficiencies, however, may now be uncovered more frequently with modern diagnostic techniques. An unusual and unreported feature of this cyst was an apudamyloid stroma. This would imply that cells derived from the neural crest participate in the formation of the cyst. Recognition of these cysts at the time of operation is important in avoiding confusion with pituitary adenomas and unnecessarily aggressive treatment.

Adenoma↗

PubMed1975

Changes in intracranial pressure and brain hydration during acute ethanolism.

Intracranial hypertension and brain hydration were scrutinized during acute ethanolism for consideration in the combined head injury setting. Intraventricular pressures and whole brain water levels rose with moderate or high ethanol dosages. The most prominent alterations were associated with respiratory acidosis and hypoxia; less marked changes were found in their absence and point to a second mechanism. Elevated central venous pressures appeared as well in some instances to constitute a third action. It is accordingly suggested that ethanol may add significantly to the combined pathology with associated acute head injury in several ways. These include: contributions to edema formation, to respiratory depression, and to alterations in local hemodyamics.

Alcoholic Intoxication↗

PubMed1974

Arachnoid clearance of red blood cells.

Labelled red blood cells were instilled intraventricularly in groups of dogs and monkeys for evaluation of transfer to the vascular compartment. Blood levels were minimal (5% of the original material) with low-pressure infusions. A large movement (above 25%) of the type originally described by Simmonds occurred with high-pressure intraventricular infusions, cisternal injections, or after the induction of intracranial hypertension. Large amounts of the label were released after cell lysis and accumulated in various tissues. Five to ten per cent of the instilled material was absorbed by the nasal lymphatic route in the dog and a significant local loss of red cells occured after posterior cisternal punctures. Simulated whole blood was useful in demonstrating arachnoid retention. Ventriculospinal washouts aided in the elimination of tagged cells only in the first 24 hours. Thereafter, the yield was small and the fluid requirement was unusually high.

Animals↗

PubMed1974