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Biomedical subjects

J D Nolan

Publications and source records attributed to J D Nolan.

14 recordsLinked to original sources
PubMed1985

Conceptual organization and memory in nonretarded, mildly retarded, and moderately retarded adults.

Moderately retarded, mildly retarded, and nonretarded adults learned a list of 12 items from three categories to a criterion of 75% correct recall in a free-recall learning paradigm. Retention was measured 1 week later. The moderately retarded took more trials and had lower retention and clustering scores than the others. The mildly retarded took more trials and had lower retention than the nonretarded. The results violate Murdock's total time hypothesis (Cooper & Pantle, 1967) but support Mandler's (1967) contention that learning is enhanced by the mental capacity for organization.

Adult↗
PubMed1977

MSH/ACTH 4-10 influences behavioral and physiological measures of attention.

Eleven healthy male volunteers were infused with MSH/ACTH 4-10 and a control solution in a completely crossed and balanced procedure. Perception, attention and memory were tested as were heart rate and cephalic pulse amplitude in response to changes in the environment. Treatment of subjects with MSH/ACTH 4-10 raised their perceptual threshold for detection of simple stimuli and facilitated perceptual integration of patterned information. Administration of the heptapeptide improved the subjects' ability to discriminate tests of relevant from irrelevant information and augmented the heart-rate deceleratory response during presentation of novel stimuli. It was speculated that MSH/ACTH 4-10 has a predominant influence on attentional processes and that it may be uniquely coded for attentional/perceptual functioning.

Adrenocorticotropic Hormone↗
PubMed1976

Neuropeptide MSH/ACTH 4-10 enhances attention in the mentally retarded.

Twenty adult mentally retarded men were randomly assigned to receive MSH/ACTH 4-10 or a vehicle control solution in a double blind procedure. After an intravenous injection the subjects were presented with an orienting sequence and a series of behavioral tests. Treatment with the peptide resulted in a significant decelerative heart rate response during the test stimulus of the orienting sequence. Improved performance of the intradimensional and extradimensional shift of a visual discrimination procedure was significant for subjects receiving MSH/ACTH 4-10. The pattern of response on the subproblem analysis of the extradimensional shift reflected greater dimensional attention in the subjects treated with the peptide. Attentive subjects given MSH/ACTH 4-10 evidenced significant improvement on a rhythm matching test, a test of spatial localization and a visual retention test. The data were interpreted as indicating that the peptide resulted in improved attention of stimulus processing. It was speculated that MSH/ACTH 4-10 may be unquely coded for perceptor/attentional functioning and may be useful as a treatment for disorders of attention.

Adrenocorticotropic Hormone↗
PubMed1975

Enhancement of attention in man with ACTH/MSH 4-10.

Normal men were infused for 4 hr with ACTH/MSH 4-10 or a control solution. Behavioral testing after the infusion indicated that subjects who received ACTH/MSH 4-10 were less anxious and had better visual memory than control subjects but the predominant effect of the heptapeptide was to increase visual attention. It was speculated that ACTH/MSH 4-10 may be uniquely coded for attentional functioning.

Adrenocorticotropic Hormone↗