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J D Schiff

Publications and source records attributed to J D Schiff.

4 recordsLinked to original sources
PubMed1985

A simple program in BASIC for least-squares fitting of certain equations to experimental data.

A program is presented that fits certain classes of theoretical equations to experimental data by the method of least squares. Equations that can be fitted by this program include all one-parameter functions and those two-parameter functions in which one of the parameters is a multiplicative factor. The program is in BASIC and thus can be used on any microcomputer equipped with that language, and its use is guided by on-screen prompts.

Biometry↗
PubMed1978

Two mechanisms of isoproterenol inhibition of smooth muscle.

The relaxation of depolarized ideal and uterine smooth muscle by isoproterenol was compared with that brought about by dibutyryl-cAMP and by other agents which increase cytoplasmic cAMP. Qualitative differences observed between the time courses of the relaxations imply the existence of a rapid beta-adrenergic mechanism independent of cAMP as well as a slower cAMP-dependent relaxation. This dual process model for beta-adrenergic inhibition of smooth muscle is consistent with seemingly opposing published reports.

Animals↗
PubMed1974

Role of the sympathetic innervation of the pacinian corpuscle.

An investigation was made into the nature of the role played by the noradrenergic innervation of the pacinian corpuscle. Corpuscles of the cat mesentery and mesocolon were used in all experiments. Blockade of noradrenergic beta receptors by dichloroisoproterenol and interference with norepinephrine release by reserpine are each capable of reversibly blocking mechanoelectric transduction by the pacinian corpuscle. The monoamine oxidase inhibitors iproniazid and phenelzine are capable of protecting the transducer from the blocking effects of reserpine. It is concluded that the presence of norepinephrine, as maintained by sympathetic tonus, is required for the afferent nerve terminal of the pacinian corpuscle to be mechanosensitive.

Animals↗