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Biomedical subjects

J D Simpson

Publications and source records attributed to J D Simpson.

At least 19 recordsLinked to original sources
PubMed1999

Scrub typhus in north Queensland.

Scrub typhus was once common in north Queensland, but no reports from this region have been published for nearly 30 years, and the focus has turned to cases from the Northern Territory and Western Australia. In 1996, diagnosis of scrub typhus in a Queensland soldier led to recognition of an earlier outbreak with up to 17 cases. Another outbreak occurred a year later with 11 confirmed cases. All cases were in soldiers who had visited a training area near Innisfail. Review of other laboratory diagnoses of scrub typhus shows it is still prevalent in north Queensland, with several "hot spots".

Adult↗
PubMed1986

Trends of performance in Arkansas cooperative beef-bull performance tests from 1962 through 1982.

Individual records of performance of 2787 bulls in cooperative beef-bull performance tests from 1962 through 1982 were analyzed to determine trends in final weight, average daily gain, daily feed consumption and gross feed efficiency. Data from Angus, Polled Hereford, Charolais, Hereford and Santa Gertrudis breeds were analyzed separately. Performance-test procedures and the ration fed remained the same in all tests. Least-squares means by year, adjusted for location of test, initial weight, initial age and initial condition score, were regressed on time to determine average yearly change in the traits. Yearly changes for Angus, Polled Hereford, Charolais, Hereford and Santa Gertrudis breeds in final weight were 3.3, 1.6, 3.3, 2.5, and 2.6 kg, respectively; in average daily gain and yearly changes were .02, .01, .02, .02, and .02 kg, respectively; in daily feed consumption the yearly changes were .08, .03, .09, and .04 kg, respectively; and in feed per kg gain the yearly changes were -.08, -.04, -.05, -.03, and -.07 kg, respectively. Because the test procedures were the same in all years, these trends represent genetic progress made by the Arkansas beef industry toward faster-gaining, more efficient cattle.

Animals↗
PubMed1982

Total body neutron activation analysis of calcium: calibration and normalisation.

An irradiation system has been designed, using a neutron beam from a cyclotron, which optimises the uniformity of activation of calcium. Induced activity is measured in a scanning, shadow-shield whole-body counter. Calibration has been effected and reproducibility assessed with three different types of phantom. Corrections were derived for variations in body height, depth and fat thickness. The coefficient of variation for repeated measurements of an anthropomorphic phantom was 1.8% for an absorbed dose equivalent of 13 mSv (1.3 rem). Measurements of total body calcium in 40 normal adults were used to derive normalisation factors which predict the normal calcium in a subject of given size and age. The coefficient of variation of normalised calcium was 6.2% in men and 6.6% in women, with the demonstration of an annual loss of 1.5% after the menopause. The narrow range should make single measurements useful for diagnostic purposes.

Adult↗
PubMed1982

Absorbed dose to man from the Se-75 labeled conjugated bile salt SeHCAT: concise communication.

The absorbed radiation dose that would result from the oral or intravenous administration of SeHCAT (23-[75Se]selena-25-homotaurocholate) has been calculated using the MIRD tables and formulas and data from measurements of whole-body distribution and from long-term whole-body counting in rats, mice, and man. When SeHCAT is administered to normal subjects, the gallbladder is the critical organ, receiving 12 mrad (oral dose) or 22 mrad (i.v.) per microcurie. The whole-body dose is 1 mrad/microCi, whatever the route of administration. In severe hepatic failure the liver might receive 200 mrad/microCi. The activity likely to be used in routine clinical practice is 10 microCi. Where a whole-body counter is used, an activity of 1 microCi has proved adequate. Even at an administered activity of 25 microCi, the absorbed dose is small compared with established techniques of investigating the gastrointestinal tract.

Administration, Oral↗
PubMed1978

Measurement of 111in DTPA clearance during radionuclide cisternography.

A new preparation of 111In DTPA for intrathecal administration has been tested and found to be a safe and highly efficacious cisternographic agent. The rate of removal of 111In DTPA from the C.S.F. and from the whole body has been measured and has been found to be of no diagnostic value in the distinction between patients with cerebral atrophy and those with normotensive hydrocephalus. Long-term retention studies show no evidence of significant long-term retention of indium in the C.S.F. The absorbed radiation dose has been investigated and found to be in good agreement with previous estimates based upon extrapolated data.

Body Burden↗