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J D Stevens

Publications and source records attributed to J D Stevens.

At least 19 recordsLinked to original sources

[Wavefront analysis and adaptive optics].

In this paper we attempt to provide an overview of the principles of wavefront measurement. We also discuss the operational principles of different systems currently present on the market including their advantages and disadvantages. Moreover, we speculate on current and possible future implications of this new technology in the laser refractive surgery. Adaptive optics are explained in the context of "customized ablation" and preoperative verification of the desired results. Finally, the first international clinical results of wavefront guided excimer laser surgery are reviewed and critically commented.

Equipment Design↗

Structure and solution equilibria of D-glucose and D-mannose sulfite adducts.

An X-ray crystallographic study has confirmed that the potassium bisulfite adducts of D-glucose and D-mannose have open-chain structures with R and S configurations respectively at C-1. NMR studies have shown that each sugar gives rise to two bisulfite compounds, and solution-state structures and conformations of these isomers have been deduced from analysis of (1)H NMR spectra. (13)C NMR data for the four adducts are given. Furanose forms of the D-glucose and D-mannose have been detected in the equilibrium solutions.

Carbohydrate Conformation↗

Preparation of 1,2-O-isopropylidene derivatives of alpha-D-galactoseptanose, beta-L-altroseptanose, and 3-O-methyl-alpha-D-guloseptanose.

Displacement of the tosyloxy group in 5-O-benzyl-1,2-O-isopropylidene-4-O-(p-toluenesulfonyl)-alpha-D-glucoseptanose has yielded derivatives of 1,2-O-isopropylidene-alpha-D-galactoseptanose. Acid catalysed acetonation then gave 1,2:3,4-di-O-isopropylidene-alpha-D-galactoseptanose or 1,2;4,5-di-O-isopropylidene-alpha-D-galactoseptanose using lower acid concentrations. Reduction of the ketone derived from 1,2:3,4-O-isopropylidene-alpha-D-septanose gave 1,2;3,4-di-O-isopropylidene-beta-L-altroseptanose. Reaction of 3,4-anhydro-5-O-benzyl-1,2-O-isopropylidene-alpha-D-galactoseptanose with sodium methoxide gave 5-O-benzyl-1,2-O-isopropylidene-4-O-methyl-alpha-D-glucoseptanose and 5-O-benzyl-1,2-O-isopropylidene-3-O-methyl-alpha-D-guloseptanose. Solution-state conformations of these compounds have been deduced from their 1H NMR spectra.

Alkenes↗

Errors leading to unexpected pseudophakic ametropia.

PURPOSE: Determination of the reasons for clinically significant unplanned ametropia following cataract surgery and the results of management of the ametropia. METHODS: Retrospective review of 11 consecutive cases of tertiary referral for management of pseudophakic ametropia to the authors. Corrective surgery involved either lens implant exchange or LASIK refractive surgery. Final outcome was assessed by uncorrected and best spectacle corrected visual acuity and manifest refractive outcome. RESULTS: Five cases (45%) were due to significant error in axial length determination at pre-surgery biometry. Six cases (55%) were due to surgeon or surgical team error, where the surgeon implanted a lens of power at variance with that specified pre-operatively. Nine patients elected to undergo refractive surgery to correct the ametropia and 2 elected to wear a spectacle lens. Seven underwent lens implant exchange and 2 patients underwent LASIK keratorefractive surgery. Eight of nine patients were within 1 dioptre of intended spherical equivalent after refractive surgery and 1 patients was -1.5 dioptre myopic. CONCLUSIONS: Most cases of serious unintended ametropia after cataract surgery are avoidable. Care should be taken with the biometry and procedural checks to minimise error. When lens implant exchange or LASIK was performed the final refractive results were satisfactory.

Aphakia, Postcataract↗

Ischaemic heart disease may predispose to pseudophakic cystoid macular oedema.

PURPOSE: Pseudophakic macular oedema (PMO) is uncommon following uncomplicated phacoemulsification and lens implantation and the cause of infrequent cases is rarely understood. This study was undertaken to determine whether a relationship exists between ischaemic heart disease (IHD) and PMO. METHODS: Retrospective case note review was carried out of 177 (252 eyes) consecutive patients without pre-existing retinal disease who underwent phacoemulsification and intraocular lens implantation during a 12 month period. Patients with a post-operative best corrected visual acuity < 6/9 underwent slit-lamp biomicroscopy and fluorescein angiography to identify PMO. IHD was defined on clinical and electrocardiographic grounds. The incidence of IHD was compared in patients with and without PMO and statistical analysis performed using the Fisher's exact test. RESULTS: PMO occurred in 4 patients (6 eyes), all of whom had IHD, whereas no PMO occurred in the remaining 173 patients (246 eyes) (p = 0.04). CONCLUSIONS: Pseudophakic macular oedema represents an important complication following modern phacoemulsification and intraocular lens implantation and is associated significantly with ischaemic heart disease.

Aged↗

Silicone intraocular lens compression and double lens implants in diseased eyes.

PURPOSE: To assess the outcomes of double lens implants in hyperoptic eyes with associated pathology. METHOD: Double lens implants were used in 4 eyes of 4 patients each with a different ophthalmic or neuro-ophthalmic disease. Biometry was performed in the standard contact fashion and lens power formulae used included SRK/T, Holladay and Hoffer Q. RESULTS: Average spherical equivalent refraction improved from +6.875 D to +0.38 D. Absolute average prediction error was greatest for SRK/T (2.65 D) and least for Holladay (1.73 D). Refractive suprises were influenced by the underlying disease process. One patient showed central lens compression. CONCLUSION: Underlying disease can produce biometry errors. Structural ophthalmic or neurological disease is not a contraindication to the use of double lens implants. Double lens implants are useful to correct refractive error in the presence of underlying disease.

Adult↗

Patient-controlled analgesia and urinary retention following lower limb joint replacement: prospective audit and logistic regression analysis.

We studied a number of factors that may be associated with urinary retention, in particular the method of postoperative analgesia delivery, in 47 men and 69 women undergoing lower limb joint replacements. The following factors were studied: age, gender, height, weight, previous history of urinary retention, presence of symptoms suggestive of urinary tract obstruction, type of anaesthetic (general anaesthetic or spinal anaesthetic), type of postoperative analgesia (intramuscular or patient-controlled analgesia with morphine) and the total dose of morphine given. Urinary retention developed in 18.1% of patients. Stepwise logistic regression analysis was used to identify independent explanators of an increased probability of developing urinary retention. Three factors emerged - male gender, increasing age and the use of patient-controlled analgesia.

Adult↗

Balanced analgesia with intravenous ketorolac and patient-controlled morphine following lower abdominal surgery.

STUDY OBJECTIVE: To investigate the efficacy, opioid-sparing effects and any reduction in adverse events of a continuous intravenous (i.v.) infusion of ketorolac following lower abdominal surgery. DESIGN: Randomized, double-blind, placebo-controlled, parallel-group study. SETTING: Inpatient elective gynecologic surgical patients. PATIENTS: 60 ASA physical status I or II patients aged 18 to 70 years scheduled for elective abdominal hysterectomy. INTERVENTIONS: Following standardized preparation and anesthesia, continuous i.v. infusions of either ketorolac or placebo were administered for 24 hours postoperatively with a patients' standardized postoperative protocol. Supplementary analgesia was administered by an i.v. patient-controlled analgesia (PCA) system. MEASUREMENTS AND MAIN RESULTS: A significantly lower proportion of the patients in the ketorolac group (6%) rated their pain at 24 hours as moderate or severe compared with patients in the placebo group (34%) (p = 0.04). Mean 24-hour morphine consumption was significantly lower in the ketorolac group (43 mg; SEM 5 mg) compared with the placebo group (55 mg SEM 5 mg) (p = 0.02). There was no significant difference in the incidence of postoperative hypoxemia between the groups with respect to mean times per hour spent with oxygen saturation (SPO2) less than 85%, more than 85% but less than 90%, or more than 90% but less than 94%, mean hourly SPO2, or the incidence and duration of severe hypoxemic episodes. Nausea and vomiting were the only significant adverse events, and they occurred in 30% of patients in both groups. CONCLUSION: Intravenous infusion of ketorolac combined with morphine delivered via a PCA device would appear to be a valuable method of providing balanced analgesia following lower abdominal surgery.

Adolescent↗

Repair of Descemet's membrane detachment after intraocular surgery.

We repaired three unselected cases of Descemet's membrane detachment. A visually successful outcome was achieved in one case, an anatomically successful outcome in another, and no improvement in the last. We believe that large detachments should be repaired early rather than waiting for possible spontaneous reattachment, and we advocate sulfur hexafluoride fluid-gas exchange as the procedure of choice.

Aged↗

Postoperative blunt trauma to 7.5 mm scleral pocket wounds.

Two patients received blunt trauma to the operated eye after phacoemulsification cataract surgery. Both patients had a three-step 7.5 mm chord width, 3.0 mm long, curving incision, extending from sclera into clear cornea. One patient had rupture of the scleral tunnel and horizontal suture 20 days after surgery. The intraocular lens was dislocated into and along the scleral tunnel. The second patient had direct trauma four days after surgery, resulting in cheese-wiring of the horizontal nylon 10-0 suture and wound leakage but no other sequelae. Blunt trauma after scleral pocket phacoemulsification cataract surgery may result in clinical wound dehiscence if sufficient force is sustained.

Cataract Extraction↗

The effect of recurrent pterygium on corneal topography.

Pterygium is known to cause corneal topographic changes that can result in decreased visual acuity. We present a case of recurrent pterygium causing blurred vision and diplopia, and document the corneal topographic changes, showing astigmatism of 15 diopters induced by lateral gaze, prior to surgical excision.

Astigmatism↗

Straight needle corneal splinting for anterior segment surgery.

Corneal splinting is an old and well established surgical technique and modern straight needles allow for atraumatic and accurate placement, providing an alternative to suture-fixation scleral ring support. We have routinely used two straight, 150-micrometer diameter, 16-millimeter length suture needles passed through clear cornea, to act as anterior segment splint supports during anterior segment surgery in which the cornea would otherwise collapse. The needles enter through the clear corneal periphery, pass across the anterior chamber, and exit through clear cornea in a criss-cross configuration. This splint technique is quick and easy to perform and is an alternative or addition to suture-fixation scleral ring support.

Anterior Eye Segment↗

Extracapsular cataract extraction in proliferative diabetic retinopathy.

PURPOSE: To establish the visual prognosis, prevalence of complications, and optimal strategy for management of proliferative diabetic retinopathy (PDR) in isolated extracapsular cataract extraction (ECCE). METHOD: This is a retrospective review of 56 patients with PDR who underwent ECCE with lens implantation. Results were compared with 64 patients with background diabetic retinopathy (BDR) operated on during the same time period. RESULTS: Final visual acuity (67% > or = 20/40) was better in BDR eyes compared with PDR eyes (21% > or = 20/40; P < 0.001). In eyes without maculopathy, 94% with BDR achieved a final visual acuity of at least 20/40 compared with 52% with quiescent proliferative retinopathy (P < 0.001). Final visual acuity in eyes with maculopathy was better in BDR eyes (36% > or = 20/40) than in PDR eyes (5% > or = 20/40) (P < 0.02). No patient with active proliferative or preproliferative retinopathy achieved a final visual acuity of more than 20/80. Postoperative deterioration of retinopathy occurred in 50% of patients with active proliferative retinopathy compared with 10% with quiescent proliferative retinopathy (P < 0.01) and 3% with BDR (P < 0.001). Immediate postoperative fibrinous anterior uveitis, which prevented early panretinal photocoagulation, developed in over half the patients with active proliferative retinopathy. CONCLUSIONS: Final visual acuity after cataract extraction in diabetic patients with proliferative retinopathy is generally poor; however, in patients with quiescent proliferative retinopathy and no maculopathy, visual acuity may be good. Active proliferative retinopathy at the time of surgery is a poor prognostic indicator for final visual acuity and is associated with postoperative deterioration of retinopathy and fibrinous uveitis, which may preclude immediate postoperative panretinal photocoagulation.

Adult↗

No-needle one-quadrant sub-tenon anaesthesia for panretinal photocoagulation.

Panretinal photocoagulation (PRP) is tolerated well by most patients using topical anaesthesia alone, though there are a significant number of patients who experience pain. Additional local anaesthesia alternatives for these patients include retrobulbar, peribulbar or subconjunctival injection. Deep introduction of a sharp needle may rarely cause damage to orbital structures, whereas no-needle sub-Tenon irrigation of local anaesthetic solution to the posterior Tenon's space theoretically avoids these risks. A one-quadrant, inferior-nasal, sub-Tenon delivery of 1.5-2 ml plain 2% lignocaine was administered and PRP performed on 12 eyes of 12 patients who were previously intolerant of PRP by topical anaesthesia alone. To assess the efficacy of anaesthesia, patients were asked to score pain, using a visual analogue score chart graded from 0 to 10. If patients were unable to see the chart, or read the accompanying text, a verbal explanation and description of the scoring chart was performed. Where PRP was performed with topical amethocaine 1% alone, pain scores were graded as median 8, mean 8.5 and range 6-10. The administration of sub-Tenon anaesthesia was well tolerated with a median pain score of 1.5, mean 1.9 and range 0-5. PRP after sub-Tenon administration was successfully completed in 11 of the 12 patients with a median pain score of 1.5, mean 1.8 and range of 0-9. The range was wide due to one patient with a high pain score who was intolerant of PRP in spite of the sub-Tenon delivery.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Topical↗

Indications, results, and complications of refractive corneal surgery with lasers.

Large numbers of patients are being treated for myopia, hyperopia, and astigmatism using the excimer laser. For many patients who are treated for myopia and hyperopia, the procedure is elective and these treatments remain investigational. The use of other lasers for refractive surgery is at an earlier stage, with human trials commencing for infrared lasers. Animal studies are being performed for pulsed picosecond and solid-state ultraviolet lasers. The indications for refractive treatment should be clearly defined, although the results of laser application remain the subject of investigation. Complications of laser application to the cornea occur in the immediate, short-term, and long-term posttreatment period. A continual improvement in refractive results along with a reduction in complications remains the goal of laser refractive research.

Forecasting↗

Curved, sub-tenon cannula for local anesthesia.

I describe a new cannula for delivery of sub-Tenon's local anesthetic solution. The cannula has a rigid structure, a 19-gauge diameter, and a shaft with a gentle curve, specifically designed to follow the contour of the globe. Anteroposterior flattening of the tip facilitates advancement of the cannula within the potential Tenon's-space tissue plane. Without the acute angulation of the shaft of the Bishop-Harmon-style cannula, it is easier to follow the globe contour and create less tenting-up of conjunctiva.

Anesthesia, Local↗