Biomedical subjects
Publications and source records attributed to J D Stroud.
Variations in the structure of the hair shaft are commonly seen under the microscope and are usually of little clinical significance. Defects of the hair shaft become significant when they produce an unsightly cosmetic appearance or when they lead to the diagnosis of an underlying metabolic disorder or genetic syndrome. The article reviews hair-shaft anomalies and presents updated information and relevant clinical guidelines for diagnosing such defects.
Telogen effluvium, alopecia areata, traction/chemical alopecia, and androgenetic alopecia account for more than 90 percent of all causes of hair loss in patients presenting to the dermatologist's office. A thorough understanding of these hair diseases will enable the practicing dermatologist to effectively manage the vast majority of patients who present with scalp hair loss.
Congenital onychodysplasia of the index fingers (Iso and Kikuchi syndrome) is characterized by five criteria: (1) congenital occurrence, (2) unilateral or bilateral index finger involvement, (3) variability in nail appearance, (4) possible hereditary involvement, and (5) frequently associated bone anomalies. Emphasis is placed on the configuration of the lunula, which is deformed and plays an important role in shaping the free edge of the nail plate. To our knowledge, this deformity has not been previously described in this syndrome.
The amount of protein solubilized with a Trisurea-mercaptoethanol buffer was markedly reduced in a patient with"spun glass" hair but normal in 3 other patients with similar appearing hair. Polyacrylamide gel electrophoresis showed that it was mainly the matrix component that was solubilized. X-ray diffraction and stress strain tests on the "spun glass" hair proved normal, as was the amino acid analysis. The cause of the insolubility has not been established.
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Explore the source record for details and available documents.