Biomedical subjects
Publications and source records attributed to J D Taurog.
A patient with a history of typical Reiter's disease developed a reversible, unilateral ascending motor neuropathy at a time when the disease was otherwise quiescent. This appears to be a case of isolated Reiter's neuropathy.
This report describes fatal colchicine toxicity occurring after a total dose of 9.3 mg. The reaction was characterized by leukopenia, thrombocytopenia, hypotension. disseminated intravascular coagulation and metabolic acidosis. Autopsy findings included a markedly hypocellular bone marrow, epithelial atypia of the trachea and esophagus, mid-zonal hepatic necrosis, sepsis and small vessel occlusion by fibrin thrombi. Possible mechanisms of colchicine toxicity are discussed.