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J D Winthrop

Publications and source records attributed to J D Winthrop.

3 recordsLinked to original sources

MR imaging in infra-, para- and retrosellar mass lesions.

To determine its diagnostic efficacy in infra-, para- and retrosellar mass lesions magnetic resonance (MR) imaging was compared with computed tomography (CT) in 39 cases. Thirty-six lesions were imaged with a Siemens 0.5 T superconducting unit, three with a 1.5 T unit. CT scanning was performed with third generation equipment. There were 28 neoplasms including eight pituitary adenomas with infrasellar extension, four meningiomas, four extensions from regional malignancies, three chordomas, three juvenile angiofibromas, three medial temporal gliomas, and one each of neuroma, epidermoid and metastasis. Eleven non-neoplastic masses included four vascular anomalies, three cholesterol granulomas, two arachnoid cysts, one sphenoid mucocele and one mixed sclerosing bone dystrophy with mass-like thickening of basisphenoid and basiocciput. While MR and CT were equally sensitive (100%), MR was superior in further delineating and characterizing a lesion. MR showed normal or abnormal blood vessels better than CT, and revealed changes of compact bone often quite satisfactorily. Effects on the brain parenchyma or CSF and airspaces were consistently well demonstrated. Provided absence of contraindications MR should be the primary radiologic screening test in suspected mass lesions of above location.

Brain Diseases↗

Suprasellar lesions: evaluation with MR imaging.

The authors retrospectively evaluated the characteristics on magnetic resonance (MR) images of 59 suprasellar lesions and compared them with computed tomography (CT) scans in 55 of the cases in which CT was performed. A diverse number of lesions were included: 17 pituitary adenomas; eight optic or hypothalamic gliomas; six craniopharyngiomas; six vascular anomalies; four lesions with extension into the suprasellar space; three metastases; two each of meningioma, hamartoma, germinoma, sarcoid granuloma, and teratoma; and one each of lymphoma, optic tract hematoma, cerebrospinal fluid-borne metastasis, pituitary hyperplasia, and sphenoid sinus mucocele. MR enabled characterization of lesions containing hemorrhage, fat, flowing blood, mucus, and cyst and allowed more specific diagnoses than CT in 6% of cases. MR was equivalent to CT in allowing lesions to be detected and in 20% of cases more accurately defined altered perisellar anatomy. Vascular abnormalities can be better evaluated with MR, and use of angiography can be avoided in some cases.

Adenoma↗

Ulcerative and granulomatous colitis in children. Comparison of double- and single-contrast studies.

The authors reviewed 49 double-contrast and 27 single-contrast barium-enema examinations (BE) in 71 children with suspected inflammatory bowel disease. The diagnosis was proved in 41 patients, of whom 36 underwent proctoscopy and 5 had advanced disease which was treated surgically within 3 to 30 days after BE; the other 30 children served as controls. BE and proctoscopy were compared with regard to sensitivity (detection of disease) and accuracy (categorization as ulcerative or granulomatous colitis). Sensitivity was 93% for double-contrast and 82% for single-contrast BE. Both detected all cases of advanced disease; in early disease, double-contrast BE detected 91% of cases and single-contrast BE 70%. Colitis was correctly categorized as ulcerative or granulomatous in 93% with double-contrast BE and 86% with single-contrast BE. Specificity within the control group was 100% with both techniques. The authors conclude that both types of BE exhibit similar sensitivity in advanced disease, but the double-contrast technique is more accurate in detecting early disease.

Adolescent↗