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Biomedical subjects

J D Woodward

Publications and source records attributed to J D Woodward.

13 recordsLinked to original sources
PubMed2001

[Ni(terpy)(H2O)]-trans-[Ni-(mu-CN)2-(CN)2]n, a one-dimensional linear tetracyanonickelate chain.

The one-dimensional chain catena-poly[[aqua(2,2':6',2"-terpyridyl-kappa(3)N)nickel(II)]-mu-cyano-kappa(2)N:C-[bis(cyano-kappaC)nickelate(II)]-mu-cyano-kappa(2)C:N], [Ni(terpy)(H(2)O)]-trans-[Ni-mu-(CN)(2)-(CN)(2)](n) or [Ni(2)(CN)(4)(C(15)H(11)N(3))(H(2)O)], consists of infinite linear chains along the crystallographic [10-1] direction. The chains are composed of two distinct types of nickel ions, paramagnetic octahedral [Ni(terpy)(H(2)O)](2+) cations (with twofold crystallographic symmetry) and diamagnetic planar [Ni(CN)(4)](2-) anions (with the Ni atom on an inversion center). The [Ni(CN)(4)](2-) units act as bidentate ligands bridging through two trans cyano groups thus giving rise to a new example of a trans-trans chain among planar tetracyanonickelate complexes. The coordination geometry of the planar nickel unit is typical of slightly distorted octahedral nickel(II) complexes, but for the [Ni(CN)(4)](2-) units, the geometry deviates from a planar configuration due to steric interactions with the terpyridine ligands.

Journal Article↗
PubMed2000

Conditioned compensatory response to ethanol as indicated by locomotor activity in rats.

Spontaneous motor activity (SMA) was used to investigate conditioned tolerance to the depressant effect of ethanol, and conditioned responses to stimuli predicting ethanol injection. Rats were injected with saline or ethanol at 800 or 1600 mg/kg, on alternate days, in two distinctly different locations, over a period of 20 conditioning days. The two ethanol doses were administered to separate groups of rats, but conditioned effects were determined by within-subject comparisons. Conditioned SMA responses (rearing and ambulatory activity) were measured after injection of saline in the location previously paired with ethanol treatment, and conditioned tolerance was determined by observing ethanol effects in rats tested in the environment previously paired with saline treatment. Ethanol-paired stimuli increased SMA (both activity measures, both dose-groups) during the conditioned response test. Absence of these conditioned stimuli during the tolerance test resulted in greater behavioral depression with the 800 mg/kg ethanol dose for both the rearing and ambulation measures; however, this effect was seen with the 1600 mg/kg dose for the rearing measure only. These results provide further evidence that Pavlovian conditioning is involved in tolerance to the depressant action of ethanol on overt behavior, and demonstrate the presence of such conditioned compensatory responses in the absence of ethanol treatment.

Animals↗
PubMed1979

Denture marking for identification.

A method for including the patient's name in the denture base material for identification purposes has been described. This simple procedure takes little time, has almost no cost, and is effective.

Denture Design↗