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Biomedical subjects

J D Woolley

Publications and source records attributed to J D Woolley.

11 recordsLinked to original sources
PubMed2006

Nucleus accumbens opioids regulate flavor-based preferences in food consumption.

Opioid signaling in the nucleus accumbens (NAcc) regulates feeding behavior, having particularly strong effects on consumption of highly palatable foods. Since macronutrient content may contribute to palatability, it is uncertain whether opioid regulation of food consumption is based primarily on its macronutrient content or its flavor per se. In order to isolate the effect of flavor, we manipulated opioid signaling in the NAcc in rats and quantified consumption of differently flavored but nutritionally identical pellets. When pellets of either flavor were presented alone, microinjection of d-Ala(2),N,Me-Phe(4),Gly-ol(5)-enkephalin (DAMGO (a mu opioid receptor (MOP) agonist)) into the NAcc increased consumption of pellets of both flavors equally. When both flavors of pellets were presented simultaneously, however, DAMGO in the NAcc selectively increased, while naltrexone (a non-selective opioid antagonist) in the NAcc selectively decreased, consumption of the more preferred flavor. Systemic naltrexone injection had no flavor specific effects, decreasing consumption of both flavors equally. Non-selective inactivation of NAcc neurons by local microinjection of muscimol (a GABA(A) agonist) increased consumption of both the more- and less-preferred flavors equally. These results indicate that opioid signaling directly regulates a subset of NAcc neurons that can selectively enhance consumption of preferred palatable foods based exclusively on flavor cues.

Analgesics, Opioid↗
PubMed2004

The autonomic and behavioral profile of emotional dysregulation.

The authors describe a patient with focal brain atrophy and emotional lability characterized by episodes of excessive crying and laughing. The patient was selectively impaired in the production of voluntary complex facial movements and was unable to regulate her emotional behavior and autonomic reactivity. She also displayed increased behavioral and autonomic changes when explicitly trying to suppress her responses to emotional stimuli (compared with when not trying to regulate her responses). This pattern of deficits supports a selective deficit in voluntary emotional control.

Atrophy↗
PubMed2000

The functional morphology of the avian flight muscle M. Coracobrachialis posterior.

The extensive range of movement of the avian glenohumeral joint makes functional interpretation of any muscle that crosses the joint difficult. Multiple functional roles for the M. coracobrachialis posterior (CBP), an architecturally complex muscle that lies deep to the M. pectoralis, have been assigned on the basis of its anatomical position. The mechanical properties, neuromotor pattern during flight and the biochemical properties of the CBP in pigeons (Columba livia) were studied by in situ length/active tension and length/passive tension measurements, in vivo electromyography and muscle histochemistry. The action of the muscle was studied directly through in situ stimulation and measurement of humeral excursion in non-reduced preparations.

Animals↗
PubMed1997

Thinking about fantasy: are children fundamentally different thinkers and believers from adults?

Young children are often viewed as being unable to differentiate fantasy from reality. This article reviews research on both children's and adults' beliefs about fantasy as well as their tendency to engage in what is thought of as "magical thinking." It is suggested that children are not fundamentally different from adults in their ability to distinguish fantasy from reality: Both children and adults entertain fantastical beliefs and also engage in magical thinking. Suggestions are offered as to how children and adults may differ in this domain, and an agenda for future research is offered.

Adult↗
PubMed1995

Young children's understanding of fictional versus epistemic mental representations: imagination and belief.

In 2 studies, 3- and 4-year-old children's ability to reason about the relation between mental representations and reality was examined. In the first study, children received parallel false belief and "false" imagination tasks. Results revealed that children performed better on imagination tasks than on belief tasks. The second study demonstrated that, when various alternative explanations for better performance on the imagination task were controlled for, children still performed significantly better when reasoning about another person's imagination than when reasoning about another person's belief. These findings suggest that children's understanding that mental representations can differ from reality may emerge first with respect to representations that do not purport to represent reality truthfully.

Child Development↗
PubMed1993

Origin and truth: young children's understanding of imaginary mental representations.

In 2 studies, we address young children's understanding of the origin and representational relations of imagination, a fictional mental state, and contrast this with their understanding of knowledge, an epistemic mental state. In the first study, 54 3- and 4-year-old children received 2 tasks to assess their understanding of origins, and 4 stories to assess their understanding of representational relations. Children of both ages understood that, whereas perception is necessary for knowledge, it is irrelevant for imagination. Results for children's understanding of representational relations revealed intriguing developmental differences. Although children understood that knowledge represents reality more truthfully than imagination, 3-year-olds often claimed that imagination reflected reality. The second study provided additional evidence that younger 3-year-olds judge that imaginary representations truthfully reflect reality. We propose that children's responses indicate an early understanding of the distinction between mental states and the world, but also a confusion regarding the extent to which mental contents represent the physical world.

Child Development↗
PubMed1990

From simple desires to ordinary beliefs: the early development of everyday psychology.

We provide evidence for the claim that before young children construe human action in terms of beliefs and desires they understand action only in terms of simple desires. This type of naive psychology--a simple desire psychology--constitutes a coherent understanding of human action, but it differs from the belief--desire psychology of slightly older children and adults. In this paper we characterize what we mean by a simple desire psychology and report two experiments. In Experiment 1 we demonstrate that 2-year-old can predict actions and reactions related to simple desires. In Experiment 2 we demonstrate that many 2-year-old pass desire reasoning tasks while at the same time failing belief reasoning tasks that are passed by slightly older children, and that are as comparable as possible to the desire tasks they pass with ease.

Child, Preschool↗
PubMed1990

Young children's understanding of realities, nonrealities, and appearances.

In 2 studies we uncover some of children's earliest conceptions of various realities, nonrealities, and appearances. In the first study, we investigated children's early understanding by examining their use of the words real and really in spontaneous speech. These natural language data consisted of longitudinal samples of 6 children's speech between the ages of 1 and 6 from the Childes database. Analyses of these samples showed that by age 3 children clearly distinguished between reality and a variety of nonreal contrasts in their everyday speech. For example, young children distinguished between toys, pictures, and pretend actions versus their real natures. We claim that, in making these distinctions, children often are considering appearances, broadly construed. To confirm this, we conducted a second experimental study with 3-year-olds, in which we questioned children about the reality and appearance of a variety of items. Results from this study confirm and clarify our findings from the natural language data. We discuss the implications of these studies for current descriptions of young children's understanding of realities and nonrealities, including their understanding of the distinction between reality and appearance.

Attention↗
PubMed1982

Paradigms and processes in reading comprehension.

This article compares several methods of presenting text, including a new paradigm that produces reading-time data with many of the characteristics of naturally occurring eye-fixation data. In the new paradigm, called the moving window condition, a reader presses a button to see each successive work in a text, and the previous work is removed when a new work appears. The words appear in the same position that they would in normal test, and word-length information is available in peripheral vision. The results are qualitatively and quantitatively compared to the results obtained by monitoring the eye fixations of subjects reading normal text. The word-level effects are generally similar. Readers pause longer on longer words, on less frequent words, on words that introduce a new topic, and at ends of sentences. The results suggest that readers initiate thr processing of each word as soon as they encounter it rather than buffer words and delay processing. Also considered are two other reading-time paradigms, one in which words are cumulatively displayed on the screen and one in which each successive word is presented at the same location on the screen. Finally, we consider how the tendency to immediately process text might interact with other techniques for text presentation, such as the rapid serial visual presentation (RSVP) condition, and we generate predictions about the nature and limits of the method.

Eye Movements↗
PubMedDate not supplied

Where theories of mind meet magic: the development of children's beliefs about wishing.

In two studies, we probed children's beliefs about wishing. In Study 1, we gathered initial data on 50 3- to 6-year-old children's concepts of wishing and beliefs about its efficacy, with both a semistructured interview and a variety of tasks. Results revealed considerable knowledge about wishing in young children, along with an age-related decrease in beliefs about its efficacy. Parents were not found to encourage differently the beliefs of children at different ages, nor were they found to begin actively discouraging such beliefs at any particular age. A moderate relation was found between environmental supports for wishing and children's beliefs in its efficacy. In Study 2, we continued to probe these issues and also address the nature of the broader conceptual context in which children situate their beliefs about wishing. Participants were 92 3- to 6-year-old children. Results of this study suggest that children may reconcile beliefs in the efficacy of wishing with knowledge about everyday mental-physical relations by situating these beliefs more within their emerging beliefs about magic than within their theories of mind.

Chi-Square Distribution↗