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Biomedical subjects

J D van Gool

Publications and source records attributed to J D van Gool.

41 records · Page 3Linked to original sources
PubMed1978

Development of reflex activity of detrusor and striated sphincter muscles in experimental paraplegia.

Reflexes concerned with viscerosomatic and somatovisceral interplay in the sacral spinal cord were evaluated in spinalized animals, as part of a study on direct spinal cord stimulation of micturition. Urodynamic evaluation consisted of continuous recording of bladder pressure, urethral pressures and electromyograms of striated anal and urethral sphincters. All exteroceptive stimuli to urethral or anal mucosa caused an inappropriate increase in afferent input to the sacral micturition center: such stimuli should be avoided in the evaluation of suprasacral lesions of bladder innervation. Early in the spinal shock phase, hyperreflexia of striated pelvic floor muscles was apparent, in the absence of detrusor reflex activity. Clinical implications for early management of neurogenic bladder dysfunction are discussed. In all spinalized animals early balanced bladder function could be achieved, due to the absence of detrusor-sphincter dyssynergia: the opposite is true for spinalized man.

Animals↗
PubMed1978

Urethral pressure profilometry with membrane catheter compared with perfusion catheter systems.

Urodynamic evaluation of urethral sphincter function can be carried out by constant carbon dioxide perfusion, constant water perfusion, or by the use of membrane catheters. A comparison of these 3 techniques was made in in vitro experiments. Results, and advantages and disadvantages of each technique are discussed. From all factors considered in this study--response to pressure changes, sensitivity to pressures along the urethra, and reproducibility of the profile--the membrane catheter was concluded to be superior to either of the perfusion systems.

Animals↗
PubMed1976

Measurement of intravesical and rectal pressures simultaneously with electromyography of anal sphincter in children with myelomeningocele.

This paper reports a technique for simultaneous measurement of intravesical pressure, intra-abdominal pressure, electromyographic activity of the external and sphincter and urinary flow. Using this technique during filling of the bladder and during micturition in 38 children with myelomeningocele and neurogenic bladder disturbance, it was possible to identify four main types of bladder dysfunction in these children. Once the type of bladder dysfunction is established for each child, adequate management can be planned far in advance of the detection of inherent upper urinary tract damage. This is particularly important in children with upper somatomotor lesions of bladder innervation in which detrusor-spincter dyssynergia may be present; this dyssynergia always causes some degree of obstruction at the level of the external urethral sphincter and is a constant threat to renal function.

Abdomen↗