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Biomedical subjects

J D van Scheyen

Publications and source records attributed to J D van Scheyen.

8 recordsLinked to original sources
PubMed1980

Platelet monoamine oxidase activity and clomipramine-induced mania in unipolar depressed patients.

During an asymptomatic phase platelet MAO activity was examined in 28 unipolar patients, 8 of whom previously had developed mania during clomipramine treatment for depression. The platelet MAO activity was not lower in these switchers than in 20 unipolar patients who did not become manic during a similar clomipramine treatment. High but nonsignificant correlations were found among platelet MAO activity and age of onset of mania, duration of clomipramine treatment before the switch, and the duration of manic behavior. These clinical variables correlated significantly amongst themselves. The high and normal platelet MAO activities of these patients neither support nor rule out a Bipolar I diagnosis. This study supports the pharmacologic basic of the induction of mania during clomipramine treatment.

Adult↗
PubMed1979

Clomipramine-induced mania in unipolar depression.

Manic behavior during randomly assigned treatment with clomipramine (chlorimipramine) or amitriptyline hydrochloride developed in seven of 50 hospitalized unipolar depressed patients. Six of the 25 clomipramine-treated patients became manic. Only one patient in the amitriptyline-treated group developed manic behavior. The switch into mania occurred at the mean age of 63, much later than the reported age of risk for mania. Significant correlations were observed between the age at onset of mania, the number of days of clomipramine treatment, and the duration of the manic episode. We hypothesize that such a switch into mania in unipolar patients is triggered by the psychopharmacological effect of clomipramine through an alleged change in activity of the central dopamine and serotonin systems.

Adult↗