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J Dábague

Publications and source records attributed to J Dábague.

5 recordsLinked to original sources
PubMed1998

Antiaorta antibodies and Takayasu arteritis.

A search for antibodies reactive against a total human aorta extract and its main protein components such as elastin, fibronectin and collagen was attempted by electroimmunetransference and ELISA. Thirty five sera from clinically and angiographically proven diagnosis of Takayasu Arteritis patients were compared with 32 sera from people without abnormalities. Non specific binding was found on electroimmune transference and no difference was shown in optical density readings in ELISA, therefore, we did not demonstrate the presence of antiaorta specific antibodies in this vasculitic condition. Our findings are in agreement with several authors, the contribution of humoral immunity to pathogenesis of Takayasu Arteritis has not been proved yet.

Adult↗
PubMed1994

Autonomic dysfunction in diffuse scleroderma vs CREST: an assessment by computerized heart rate variability.

OBJECTIVE: Autonomic dysfunction has been described in scleroderma. Heart rate variability gives information about sympathetic-parasympathetic autonomic balance, therefore it can provide insight into which division of the system is most affected. Our purpose was to determine whether the neural control of heart rate in patients with CREST syndrome differed from that in patients with diffuse scleroderma. Since low heart rate variability in some diseases is associated with an increased risk for malignant ventricular arrhythmias, assessment of patients with scleroderma with this technique might establish a marker of adverse outcome. METHODS: A short time analysis of heart rate variability was performed in 9 patients with diffuse scleroderma, 8 with CREST and 17 age/sex matched healthy controls. RESULTS: An abnormal heart rate variability was found in patients with CREST: There was a reduced standard deviation of the mean of beat-to-beat R-R intervals and a low power spectrum density in both the 0.05 to 0.15 Hz band and the 0.15 to 0.35 Hz band, a significant reduction in their total power (p < 0.05), a reduction in the high frequency to total power ratio (p < 0.05), and a reduction in the ratio between high and low frequency components of their spectrum. CONCLUSION: It is suggested that patients with CREST have a decreased parasympathetic control of heart rate, significantly different from those with diffuse disease. Whether this finding is pertinent to the differences between these subsets of patients remains to be established.

Adult↗
PubMedDate not supplied

[Does heart sarcoma mimick lupus erythematosus and vasculitis? Report of 2 cases].

Primary heart tumors are rare. The most common one is myxoma. It may synthetize IL-6 and frequently shown systemic clinical manifestations that confuse the diagnosis. Primary heart sarcomas are even more rare, as far as we know they have been not associated with systemic illnesses. We observed two cases with a presumptive diagnosis of systemic lupus erythematosus who were identified as primary sarcomatous heart neoplasms after surgical excision.

Adult↗