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Biomedical subjects

J Darewicz

Publications and source records attributed to J Darewicz.

At least 19 recordsLinked to original sources
PubMed2002

Microsurgical replantation of sexual organs in three patients.

OBJECTIVE: The present study deals with microsurgical replantation technique. MATERIAL AND METHODS: The technique was applied in 3 patients whose sexual organs had been accidentally cut off. RESULTS: Necrosis of the sutured organs occurred in 2 cases. In 1 case, however, healing with proper miction and sexual function was achieved. Prolonged period (over 12 hours) from the accident to operation as well as the extensive injury of tissues with the vascular system crush were considered to be the main reason for failure. CONCLUSIONS: Microsurgical reconstruction of penis and testes with the use of vessel grafts prolonged the hypoxia which led to necrosis. Disturbances in vein blood outflow from the sutured organs contributed to this process as well. The third case resulted in success mostly due to quick intervention (5 h from injury) as well as to proper microsurgical reconstruction of vessels, nerves, and urethra. In addition suprapubic urine diversion was successfully applied and the urethra healed on the perforated catheter. Routine antibiotics as well as antithrombotic prophylactics were administered in all of the 3 cases.

Adolescent↗
PubMed2001

Successful microsurgical replantation of an amputated penis.

Traumatic amputation of the penis is a rare condition. The paper presents a 22-year old man who suffered a complete penile amputation in a result of an unfortunate accident. Microsurgical replantation of the penis was performed in the case with a complete return of sensation, sexual function and physiologic miction. Microsurgical replantation is the treatment of choice for this injury.

Adult↗
PubMed2001

Ultrastructure of the tunica albuginea in congenital penile curvature.

PURPOSE: We investigated the ultrastructure of the tunica albuginea in individuals with congenital penile curvature to explain the pathology of this disease. MATERIALS AND METHODS: Included in our study were 15 patients 17 to 24 years old with congenital penile curvature. Study material consisted of samples of the tunica albuginea excised from the greater curvature of the corpus cavernosum during surgical correction. Control samples were obtained from the lesser curvature on the side opposite the study material during the same operation. The 2 types of tissue were analyzed using transmitter electron microscopy. RESULTS: Ultrastructural examination of the control material revealed numerous collagen fibers that were homogenous in size and organization on cross section. Periodic striation was typical in collagen that produced fibers. In the study group the tunica albuginea structure had a chaotic pattern of collagen fibers that formed bundles with disrupted 3-dimensional organization. Diameter of the fibers differed greatly on cross section. We observed periodic widening and fragmentation of collagen fibers with the complete disappearance of striation and transformation into electron dense, fibrous granulated material. Disrupted fibroblasts without cell membrane and cellular organelles between collagen fibers were also visible. There was elastin accumulation without any morphological differences in the control and study groups. CONCLUSIONS: Our results show that ultrastructural changes in the tunica albuginea may cause congenital penile curvature, possibly by altering mechanical properties.

Adolescent↗
PubMed2000

Platelet serotonergic mechanisms in patients with cancer of the urinary bladder.

Platelet reactivity of hypertensive patients and patients with cancer of the urinary bladder was examined in vitro in comparison with normotensive patients. A significant increase in free serotonin in the plasma of patients with cancer of the bladder and a less pronounced increase in hypertensive subjects was observed. The platelets in neoplastic disease and hypertension showed a significant reduction in the kinetics of serotonin uptake. However, the release reaction was markedly higher, compared with healthy volunteers. Enhancement of platelet aggregation with serotonin was much greater in patients with cancer of the bladder than in control groups and in hypertensive patients. These data indicate increased sensitivity to serotonin within the platelets of patients with cancer of the urinary bladder.

Adenosine Diphosphate↗
PubMed2000

Haemorrhagic complications of percutaneous lithotripsy: original methods of treatment.

698 patients treated for nephrolithiasis with the application of percutaneous lithotripsy were analysed. In 32 cases increased bleeding in the course of the procedure occurred. It was controlled without surgery with blood transfusion, constant renal saline flow maintenance, electrocoagulation, kidney parenchyma pressing with thick drain and approach canal tamponade. In one case the approach to the kidney was obtained surgically and the kidney parenchyma was stitched with haemostatic suture. One patient required selective embolization due to kidney haemorrhage after nephrostomy drain removal.

Female↗
PubMed1998

Embolization and serum lysozyme activity in renal cancer.

The aim of the study was to determine the effect of renal tumor embolization on nonspecific immunity by evaluating lysozyme activity and leucocytosis in 45 patients and 40 healthy people. Lysozyme activity was assessed in the non-diluted serum (A1) and in the tenfold diluted serum (B1) prior to embolization and after embolization (A2, B2) and in control group. Prior to embolization, lysozyme activity was lower in the experimental group (A1 and B1), compared to the control groups, the differences being statistically significant (p < 0.05). After embolization, the activity became normalized (A2), reaching the control value and even exceeding it (C) in the diluted serum (B2). Leucocytosis prior to embolization (L1) resembled that of control group, increasing slightly after embolization (L2). The differences observed in the changes in lysozyme activity and leucocytosis were statistically significant (p < 0.05). Our findings indicate an inhibitory effect of the neoplastic process on nonspecific immunity. Embolization causes ischemic necrosis of tumor and products of neoplastic tissue disintegration exert a stimulating effect on granulopoiesis, by increasing the turnover of neutrophilic granulocytes. Granulocytic-monocytic infiltrations in tumor stroma are the source of lysozyme, enhancing not only local but also systemic immunity, which is manifested in the increased lysozyme activity in blood serum.

Adult↗
PubMed1998

The activity of neutrophil myeloperoxidase in patients with renal cancer before and after embolization.

The activity of granulocytic myeloperoxidase (MPO) was investigated in 45 patients with renal cancer before and 14 days after renal artery embolization in comparison with control group of 40 healthy people. The group examined showed lower MPO activity before embolization, as compared to controls. The differences being statistical insignificant (p > 0.05). After embolization the activity MPO was normalized, reaching the mean value of control group. The findings revealed reduced granulocytic MPO activity in patients with renal cancer.

Adult↗
PubMed1998

Nitroblue tetrazolium test in patients with renal tumor in the course of embolization.

The main role of neutrophilic granulocytes is phagocytosis and destruction of phagocytized bacteria. The nitroblue tetrazolium test (NBT), used to evaluate the bactericidal function of granulocytes, was assessed in 45 patients with renal tumour before and 14 days after renal artery embolization. No statistically significant spontaneous test NBT differences were found, compared with control group both before and 14 days after embolization. Following stimulation granulocytes in vitro by LPS of E. coli the ability of granulocytes to reduce NBT was lowered. The differences, as compared with control group, were statistically significant (p < 0.05). Our results indicates considerable impairment of lower metabolic reserve in patients with renal tumour necessary for maximum stimulation.

Adenocarcinoma↗
PubMed1996

Microsurgical replantation of the amputated penis and scrotum in a 29-year-old man.

A 29-year-old mentally ill farmer underwent microsurgery for the resuturing of the penis and testicles which he himself had chopped off with an ax. Microsurgery of the urethra, corpora cavernosa, arteries and veins was begun 10 h after the trauma. The veins, arteries and testicles were anastomosed and covered with a free flap of the scrotum skin. Three weeks after surgery, the anastomosed tested showed good healing. However, in 65% of the penis, necrosis had occurred.

Adult↗
PubMed1995

[Stamey-Lorenz operation for treatment of stress urinary incontinence in women].

The Stamey-Lorenz operation was presented as a new method for treatment of stress urinary incontinence in women. During operation the urethra is suspended by using special needles and under cystoscopic control, thus proper vesico-urethral angle is restored. 10 incontinent women were cured using this method, 8 with good results. In two cases we failed.

Adult↗
PubMed1989

[Two cases of penis fracture with injury to the urethra].

Two patients with penis fracture with urethral damage during sexual intercourse are reported. The patients were treated surgically although in one case the time after fracture was 28 hours and in the second case 12 hours. The therapeutic results were very good in both cases, and the authors believe that surgery is the treatment of choice in cases of penis fracture.

Adult↗
PubMed1989

[Ligation of the vena dorsalis penis profunda in treating vascular-induced impotence].

It is reported on the diagnosis and treatment of vasculogeneic impotence. With the use of dynamic cavernosography in 6 patients changes in the venous system were detected and therefore the profound dorsal penile vein was ligated. In 4 patients the sexual function could be improved. The results are encouraging in the case of safe diagnosis and adequate operative treatment.

Adult↗
PubMed1989

[Priapism as a complication following diagnostic papaverine test].

In 5 out of 84 patients suffering from impotence a prolonged erection was observed after intracavernous papaverine injection. Treatment consisted of puncture of the cavernous body, blood evacuation and intracavernous adrenaline injection. In 4 patients erectile function could be preserved and in the fifth patient a penile prosthesis has been implanted.

Adult↗