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J Darsinos

Publications and source records attributed to J Darsinos.

10 recordsLinked to original sources
PubMed1988

Hemodialysis with calcium-free dialysate prevents myocardial creatine kinase depletion after brief coronary artery occlusion in dogs.

To evaluate the effect of hypocalcemia on myocardial creatine kinase (CK) depletion after brief coronary artery occlusion and reperfusion, dogs were rendered hypocalcemic via systemic hemodialysis for eighty minutes in the absence of Ca. Control animals were hemodialysed in the presence of Ca. The left anterior descending coronary artery was then occluded for six minutes and reperfusion for eighty minutes occurred at low flow of dialysate. A 50% decrease in serum Ca of the hypocalcemic animals during the eighty minutes of hemodialysis resulted in a significant (about 35%) decrease of myocardial Ca. Comparison of the myocardial creatine kinase activity following reperfusion showed preservation of the enzyme in the ischemic areas of the hypocalcemic animals, whereas the CK activities of the ischemic areas of the normocalcemic animals were much lower (p less than 0.005). During the reperfusion period serum Ca of the hypocalcemic group increased to 75% of that of the normocalcemic group while myocardial Ca of both ischemic and nonischemic areas reequilibrated to normocalcemic values. Hemodynamic parameters during the various phases of the experiment were not altered significantly. It is concluded that transient decrease of myocardial Ca produced by hypocalcemia prior to occlusion leads to protection against myocardial damage after brief coronary ligation.

Animals↗
PubMed1985

Effect of haemodialysis on coronary occlusion-reperfusion ventricular fibrillation.

The effect of (HD) on occlusion-reperfusion (VF) was studied in 22 dogs. The (LAD) coronary artery occlusion lasted 25 min, and followed by reperfusion for 30 min, in 12 dogs with (HD) (group A) and in other 10 dogs (group B) without (HD). A significantly (p less than 0.05) lower frequency of appearance of (VF) during occlusion-reperfusion was seen in the group A undergoing (HD) (2 out of 12 dogs) in comparison to the control group B (7 out of 10 dogs). It is concluded that the (VF) of coronary occlusion-reperfusion can be prevented by a "non-pharmaceutical" intervention such as hemodialysis.

Animals↗