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J Dauverchain

Publications and source records attributed to J Dauverchain.

17 recordsLinked to original sources
PubMed1996

Exercise-induced death in sickle cell trait: role of aging, training, and deconditioning.

The pathophysiological process of exercise-induced death in subjects with sickle cell trait (SCT) remains unclear. Concerning the cause of death, authors have suggested stressful environmental conditions such as altitude, heat and humidity, or abnormal patient conditions such as deconditioning, fatigue, and disease. These conditions are thought to lead to hypoxemia, hyperlactatemia, acidosis, dehydration, hyperthermia, or exercise-induced rhabdomyolysis, all of which may initiate sickle cell crisis, disseminated intravascular coagulation, myoglobinuria, and renal failure. We report the case of a 41-yr-old, healthy, and apparently well-conditioned subject with SCT who died during a cross-country race under normal environmental conditions in good weather (in terms of temperature and humidity). The medical and athletic history of the subject were unremarkable. We refer to an epidemiological study that reported a relation between age and exercise-induced sudden death in subjects with SCT. We then review the pathophysiological effects of aging in association with deconditioning and high-level training reported in the literature, particularly the decrease in aerobic metabolism in deconditioned subjects, and the exercise-induced hypoxemia in highly trained subjects. We discuss the consequences of deconditioning and high-level training in subjects with SCT during exercise, and conclude that these factors may be involved in the age-dependent risk of exercise-related sudden death in subjects with SCT.

Adult↗
PubMed1988

[Ambulatory blood pressure and heart rate at 60 +/- 5 years. Differences between men and women].

Ambulatory measurements of systolic and diastolic arterial pressures and heart rate were performed during daytime in 68 subjects (37 men and 31 women) of mean age 55 +/- 5 years. These subjects had no history of cardiovascular or cerebral disease and no clinical or biochemical abnormalities. Bar charts for ages showed unimodal distribution with a 59-year mode in both sexes. Hourly profiles of arterial pressures and heart rate from 09:00 to 22:00 h were established in both groups. Throughout that time ambulatory arterial pressures were constantly higher in men than in women, especially in the morning (about 09:00 - 10:00 h; p less than 0.01), late in the afternoon and in the evening (17:00 to 22:00 h; p less than 0.01). In contrast, women always had a higher heart rate than men, the difference being greatest in the morning till early afternoon (10:00 to 15:00 h; p less than 0.01) and in the late evening (22:00 h; p less than 0.01). A difference in arterial pressures between men and women has already been recognized in younger subjects. It would be interesting to find out whether it increases or decreases in subjects older than those of the present study.

Age Factors↗
PubMed1979

[The role of nicergoline in the symptomatic treatment of arterial hypertension and chronic cerebrovascular insufficiency. A study on 359 observations (author's transl)].

An examination was carried out on the efficacy of 10-methoxy-1,6-diemethyl-ergoline-8 beta-methanol-(5-bromonicotinate) (nicergoline, Sermion) on the symptoms of functional side effects of arterial hypertension and chronic circulatory insufficiency as regards the psychomotoric activity and the relational activity; 359 patients suffering from crebrovascular insufficiency were included in the study. The compound was applied in a daily dose of 10 mg i. m. for 5 days and then in a daily dose of 15 mg orally for 1 month. In the entire symptom complex of cerebro-vascular insufficiency a positive effect of nicergoline could be observed; the results of all clinical criteria and their therapeutic relevance are discussed.

Adult↗