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Biomedical subjects

J David-Chausse

Publications and source records attributed to J David-Chausse.

8 recordsLinked to original sources

[Osteomalacia. Histologic definition and significance of the histodynamic analysis on undecalcified bone].

Bone histomorphometry has a major significance in metabolic bone diseases, and especially in osteomalacia. This technique needs a strict methodology with quantitative analysis on undecalcified bone and measure of calcification rate. Histologic definition of osteomalacia includes hyperosteoidosis, characterized by thickened osteoid edges, and decrease of calcification rate. Histodynamic analysis on undecalcified bone provides interest in diagnosis, prognosis and supervision of this affection.

Biopsy

[Bone mastocytosis and osteomalacia. Apropos of a case with histodynamic analysis on non-decalcified bone].

A patient presented with cutaneous mastocytosis, bone pains, biologic disorders typical of osteomalacia, and intestinal malabsorption. Bone biopsy with histomorphometric analysis and measure of calcification rate on undecalcified bone, confirmed the diagnosis of bone mastocytosis and osteomalacia. There are only 2 other reports of osteomalacia caused by malabsorption. The latter is possibly bound to a mast-cell infiltrate of the intestinal mucosa. Sometimes only villosity atrophy or oedema of the mucosa are observed.

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