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Biomedical subjects

J De Mol

Publications and source records attributed to J De Mol.

At least 19 recordsLinked to original sources

[Fetal alcoholism syndrome: apropos of a case].

Fetal alcoholic syndrome (F.A.S.) is a well-recognized entity for over 20 years; it associates mental retardation, delayed growth and anomalies of the cranium in children born from alcoholic mothers. The syndrome has been described primarily in young children. By contrast, its evolution is not well known. We report the case of a 15-year old youngster, who exhibited the characteristic features of F.A.S. We also review the data related to the clinical and pathophysiologic aspects of the syndrome.

Adolescent

Portal vein thrombosis after acute pancreatitis: diagnostic confirmation with computed tomography during arterial portography.

Portal vein thrombosis is a rare complication of pancreatic inflammatory disease. Usually, the radiologic diagnosis is made either by ultrasonography, contrast-enhanced CT or angiography. Moreover, MRI seems a very promising method. CT during arterial portography (CTAP) focused on portal system proved to have a place in the evaluation of portal vein thrombosis in a particular case.

Acute Disease

Effects of methionine hydroxy analog on voluntary intake, digestibility, nitrogen balance, and chewing behavior in sheep fed grass silage.

Voluntary intake, digestibility, N balance, and chewing behavior of six 6-mo-old (young) and six 30-mo-old (mature) Texel wethers (32.6 and 83.1 kg average BW) given ad libitum access to grass silage and 100 g of top-dressed soybean meal with or without 5 g of methionine hydroxy analog (MHA) in the acid form were examined according to a two-period crossover design. Supplementation level of MHA in the acid form corresponded to .32 and .16 g of MHA/kg BW.75, respectively, in young and mature wethers. There was no effect (P greater than .10) of MHA on mean voluntary DMI. Methionine hydroxy analog supplementation increased (P less than .02) digestibility of DM, OM, and CP by young wethers but not (P greater than .18) by mature wethers. The MHA decreased eating time (P less than .03) in both young and mature wethers and intake level (P = .01) in young wethers during the first 1.5 h of access to grass silage. With MHA, both age groups increased (P less than .05) the daily number of meals and decreased (P less than .02) the mean duration of each meal. There was no effect (P greater than .06) of MHA on daily and unitary eating, ruminating, and masticating times; however, mean duration of consecutive rumination bolus cycles was longer (7.2%; P = .01) in young wethers. Young vs mature sheep ate more (53.4 vs 39.3 g of DM/[d.kg BW.75]; P less than .001) and had shorter unitary mastication times (P = .001). Results suggest that, depending on its relative level of supplementation, MHA in the acid form could act through both palatability and effects on ruminal metabolism.

Animal Feed

Clonidine-induced growth hormone secretion in elderly patients with senile dementia of the Alzheimer type and major depressive disorder.

This study was undertaken to assess the value of growth hormone (GH) response to clonidine as a tool in the differential diagnosis between depression and dementia. This response is known to be blunted in depression, and neurochemical changes observed in senile dementia of the Alzheimer type (SDAT) could lead to an up-regulation of GH secretion. No difference was observed between GH response in depressed and demented patients. Together with studies on GH basal secretion in Alzheimer's disease, this finding suggests that the final consequence of SDAT-related changes in an accentuation of the effects of aging on GH reactivity.

Aged

Psychological sequelae after head traumas in adults.

Head trauma can generate various psychopathological sequelae either in intellectual functions or personality. The post-traumatic sequelae that are focused on in this work are memory disturbances, dementia and personality problems. It partially sums up fifteen years of psychological studies on head injuries conducted in the department of neurosurgery of Prof. Jean Brihaye.

Attention

[Rorschach test and post-traumatic depressive syndromes].

After reviewing the literature on post-concussional syndrome in head injured patients and some studies which have contributed to objectify post-traumatic personality characteristics, the authors were particularly interested in studying depressive signs complained of by such patients without any psychopathological history. The analysis of a group of 47 head injured patients shows that one in two patients openly revealed such depressive tendencies. These patients, who were observed on average less than one year after the trauma, do not differ from the others, whether by age, sex, the severity of the head injury, the existence of a neurosurgical operation. However, they showed many symptoms which were different from those of the other patients in the group and different from those of the whole group. This "depressive" syndrome appears in a more specifically anxious form. The study of the Rorschach's test, on the other hand, does not show any change in the basic personality, especially inhibited in the two groups. For the patients who do not complain openly of depressive signs, the hypothesis of a masked depression was raised. This perspective is compared with the literature's data and allowed to point out several forms of post-traumatic depression.

Adolescent

[Neuropsychological symptomatology in normal pressure hydrocephalus].

The neuropsychological observations of 63 patients undergoing surgery for "normal pressure hydrocephalus" (NPH) have been analyzed retrospectively. To make a semiological picture of mental disturbances in NPH, the level of consciousness, behaviour and cognitive functions were studied. A neuropsychological investigation of the main cognitive functions (language, gnosis, praxis, calculation, memory) enables us to specify the characteristics of dementia shown by these patients. A mental picture of the most frequent neuropsychological signs is described. The mental syndrome which characterized NPH reveals an alteration of alertness and concentration, a deficiency in memory, a disorganization of graphism (writing and drawing), a dyscalculia and behaviour problems (bradypsychy, apathy, indifference). Such a syndrome points out a bilateral frontal lesion. On the other hand, the less frequent signs are largely verbal and show different stages of aphasia. These signs can usually be found in patients who don't improve after ventricular drainage and are more suggestive of a degenerative disease of the Alzheimer type. The results are compared with the psychometric and neuropsychological data of the literature. More specific attention is accorded to differential diagnosis.

Adolescent

[Post traumatic schizophrenic bouts: with regard to 6 cases of traumatic schizophrenia (author's transl)].

The authors describe 6 cases of post-traumatic schizophrenia and make a critical review of the literature concerning this unusual post-traumatic personality disturbance. Various schizophrenic manifestations are observed: they principally consist of delusion, hallucination, paranoid and mystical ideas, autism, psychomotor instability, fugues. Post-traumatic schizophrenia occurs mostly in young men, before thirty years. The severity of traumatic brain injury appears irrelevant in its genesis. Temporal lobes are more often involved (one third of the cases). Pre-traumatic personality disturbances are the main factor as demonstrated by the anamnesis and by the results of Rorschach test.

Adolescent

[Normotensive hydrocephalus. Retrospective clinical study of 47 cases].

The clinical observation of 47 patients, undergoing surgery for "normotensive hydrocephalus" during the period January 1975 to January 1981 have been analysed retrospectively. The condition of half the patients improved following insertion of a cerebrospinal fluid bypass. Complications of varying degrees of severity were noted in 21 percent of cases. The correlation between the post-operative results and the clinical data was subjected to statistical analysis. Some factors appeared to have an important predictive value. These were the age, the absence of cortical atrophy on C.T. scan and the prolonged ventricular filling on cisternography. Other factors, although without statistical significance, seem to predict a better result: the existence of prior etiological data, presence of a frontal syndrome and evidence of periventricular hypodensity on C.T. scan. Finally, some other factors in our series appeared to have no influence on the prognosis. These were: duration of the preoperative evolution of the disorder, the degree of mental disturbance and difficulties of gait, the presence of urinary incontinence, the value of the ventricular cranial ratio. None of the recognized significant criteria was sufficiently reliable to predict the quality of surgical result, when studied in isolation. The association between the different significant criteria, such as have been described above notably, improves the chances of a favorable post-operative outcome but it is insufficient to predict it with great certitude. The continuous monitoring of the intracranial pressure during periods of 24 to 48 hours appears to be the most reliable factor on which to make a decision to operate in the light of the findings described in recent literature.

Adult

[Personality disorders in head injured adults].

Personality changes and behavioral disturbances have been studied in nineteen adult head-injured patients who did not present the usual features of the "post-traumatic syndrome". The characteristics of this group of patients are described: sex, age, severity of the injury, brain damage localization and associated neuropsychological symptoms. The premorbid personality and psychopathologic antecedents are analyzed. After comparing the results of this study with those reported in the literature, the author comes to the conclusion that behavioral disorders and personality changes in head-injured patients do not show any clear correlation with the severity of the injury but are more likely to occur after temporal lobe damage and especially in patients with a previous history of neurotic or psychopathic symptoms.

Adolescent

[Psychic disturbance in normal pressure hydrocephalus (author's transl)].

After reviewing the literature on psychic disturbance in normal pressure hydrocephalus, the author reports on 26 cases of CSF drainage. Impairment of memory and concentration were always present in normal pressure hydrocephalus; behaviour disorders were very frequent and characterized by both types of frontal behaviour; the mental picture also comprised difficulties of calculation, writing, visuoconstructive praxis and, less frequently, impaired speech and reading ability. CSF drainage brought clinical improvement in 73% of the cases. Disorders of consciousness, mental function and behaviour regressed generally progressively as soon as the operation had been performed. Two major factors affecting therapeutic efficacity appear to be the patient's age and the length of time between onset of the symptoms and start of therapy.

Adolescent

[Trial of a new therapeutic agent, Pervincamine, in the post-concussion syndrome of patients with head injuries. Application of a double-blind control system and sequential analysis].

The authors have studied the influence of Pervincamine on the postconcussional syndrome in a group of 30 patients with cranial trauma examined for at least six months after their accident. The double blind testing was utilised and the patients were followed at regular intervals spanning three weeks. Each patient was evaluated by semi-directed interviews and tests of "double barrage" of Zazzo and the 15 words test of Rey. In addition, an EEG was performed at the beginning and the end of the study. Statistical analysis of the evolution of symptoms and the results obtained by psychological testing has revealed the positive action of Pervincamine on the postconcussional syndrome and on mental as well as motor functioning in general. Furthermore, the secondary effects of this product are negligible.

Adolescent

[Psychodynamic aspects of personality of patients with Parkinsonism].

After reviewing the literature on personality and Parkinsonism and recalling the two concepts which conflict on the etiology of their personality, the author has examined Rorschach charts of 20 Parkinsonians. This was done through formal analysis and content analysis in order to show the various dynamic aspects of personality, the psychic mechanisms preferentially used and the possible relations between psyche and soma. The results reveal a modification of personality in the direction of global narrowing, on ideas and affect, a reduction of relational investments, a narcissitic and hypochondriac retrieval and an important reduction of affects. Two different types of personality appear out of this common branch. The first is characterized by rigidity and stereotipy, the second characterized by some smoothness and a wider opening toward the external world. The psychodynamic study reveals that personality reorganization takes place through libidinal retrieval, through defensive and narcissisic move. After the completion of the study, the somatopsychic hypothesis remains most produce; however the premorbid personality and in particular the aggressive problem can integrate with the behavioral modifications due to Parkinson's disease in order to finally bring a original psycho-affective picture.

Affect

[Epileptic psychosis--ictal psychosis?].

A 54-year-old female patient presented acute hallucinatory psychotic episodes with irritative EEG for seven years before an initial state of complex partial mal. A single convulsive episode occurred 14 years after the beginning of the psychiatric symptoms. The intercritical EEG showed independent temporal lobe foci predominating on the right. It varied little during delirious phases but these occurred three times during weaning from antiepileptic drugs. The delirium improved when the treatment was restored, whereas neuroleptics proved ineffective. Psychiatric signs frequently described in epilepsy and particularly temporal epilepsy are reviewed. Usually, these symptoms are not concomitant. The literature mentions only a very few cases where psychosis appears to be ictal as in the reported case.

Electroencephalography

[Hydrocephalic and/or degenerative dementia].

The authors report ten cases of progressive dementia. Nine are associated with gait disturbances and seven with urinary incontinence. Despite the severity of dementia and Ct Scan signs of cortical atrophy, magnitude of neuroradiological ventricular dilatation and ventricular reflux at isotopic cisternography lead to shunt therapy. After ventricular shunting of CSF, a follow-up at short and long terms shows different clinical evolutions: two transitory improvements, three cases without change and five worsening. Retrospective clinical study of these cases in which diagnosis leads to a degenerative process of the Alzheimer type shows atypical premorbid neuropsychological characteristics by a normal-pressure hydrocephalus. In fact, in the ten cases preoperative neuropsychological investigation shows, at various levels, aphasic, alexic and agraphic signs. Their occurrence in the clinical picture represents an essential contribution to differential diagnosis.

Adolescent

[Computer hardware for a surgical service].

While the bulk of all medical information is text, we think that the hardware needed to collect this information and to store it in a databank, must be essentially a first class work processor, working in a multi-user system with terminals where this information is gathered: the nursing stations, operating theatres, outpatient clinics and a working and archiving station centrally placed and capable to link those different terminals and those from other services as well.

Computers

[Prognostic factors for therapeutic outcome in normal-pressure hydrocephalus. Review of the literature and personal study].

In view of the unpredictable percentage of NPH patients who benefit from surgery and the risk of postoperative complications, the study of predictive parameters appears essential. The literature shows many conflicting results in studies which focus on predictive values. The present study is based on a series of 63 patients, all of whom underwent surgery for NPH. Fifty one historical, clinical, paraclinical and neuropsychological parameters were submitted to statistical analysis on the basis of the postoperative results. Nine of these parameters were correlated with the postoperative evolution: aetiology, chronic alcoholism and seven neuropsychological signs, in particular verbal signs. A statistical analysis by logistical regression allows us to describe an optimum predictive model. The most significant results are discussed.

Adolescent