Biomedical subjects

J De Sutter

Publications and source records attributed to J De Sutter.

42 records · Page 3Linked to original sources

PubMed1995

A case of Peutz-Jeghers syndrome with nasal polyposis, extreme iron deficiency anemia, and hamartoma-adenoma transformation: management by combined surgical and endoscopic approach.

We report a rare variant of Peutz-Jeghers syndrome identified by the presence of nasal polyposis and extreme anemia. Multiple hamartomatous polyps were found throughout the upper and lower gastrointestinal tract. We conducted a combined surgical-endoscopic approach to prevent the development of a short-bowel syndrome. The polyps removed by snare and surgical polypectomy showed features typical of harmartomas. Three colonic polyps and two nasal polyps showed histological evidence of adenomatous change. This adenomatous change seems to fit into the pathogenic sequence of hamartoma-adenoma.

Adult↗

PubMed1994

Cardiovascular responses elicited by different simulated diving manoeuvres.

It has been documented that placing an ice-bag on the forehead causes similar cardiac and vascular responses as face immersion. There has been disagreement concerning the contribution of separate cold stimulation on the face and breathholding in the diving response. This study set out to unravel the extent to which these two factors contribute individually to the observed cardiovascular changes during the combined manoeuvre. It further aimed to reveal whether peripheral vascular responses to these stimuli are different in forearm and calf. We observed a significant rapid increase in the RR-interval, which was maintained until the end of the 25-s observation period and a homogeneous vasoconstriction in forearm and calf, despite minor changes in arterial blood pressure, during breathholding, placing the icebag on the forehead and the combined stimuli. Cardiac and peripheral vascular responses to the combined manoeuvre did not differ significantly from the responses elicited by the two stimuli separately. This test is another example that illustrates the heterogeneous cardiovascular response involving both parasympathetic and sympathetic activation. Moreover, since the icebag on the forehead test is technically easy to perform and does not require the active co-operation of the patient, it may be a valid method to replace a full face immersion test accompanied by breathholding.

Adult↗

PubMed1993

Peripheral vascular changes and ambulatory blood pressure profiles.

This study aimed to correlate blood pressure (BP) level assessed either by casual or by 24-h ambulatory BP monitoring and regional (calf and finger) blood flow and associated vascular resistance in subjects with low, intermediate, and high BP. In 75 subjects covering the range from low BP to normo- and hypertension, blood flow at calf and finger vessels were simultaneously measured using an ECG-triggered venous occlusion plethysmograph. Correlations were calculated between regional blood flow or vascular resistance and BP defined from casual and from 24-h ambulatory BP registrations, at rest, and after 3 min of arterial occlusion (reactive hyperemia). Correlations over the whole BP range, between calf and finger vascular resistances and BP, were highly significant both for casual (0.650 < r < 0.776) and for ambulatory (0.531 < r < 0.781) BP. The relations remained significant after adjustment for the age dependency of the blood pressure. At any BP level skin (finger) blood flow at rest and after arterial occlusion was higher than muscle (calf) blood flow. These data indicate that there is a progressive decrease in vasodilating capacity from low to high BP in both muscle and skin vessels. However, in the zone of borderline to moderate essential hypertensives, blood flow after 3 min arterial occlusion was already significantly decreased in the muscle circulation when compared to normotensives, while still maintained in the skin circulation.

Adult↗

PubMed1993

On the relationship between regional circulation and systemic blood pressure.

OBJECTIVES: The relationship between regional circulation (blood flow or calculated resistance) and systemic blood pressure (BP) is only poorly documented in the range of intermediate to low BP. METHODS: In 75 subjects covering the BP range from low, over intermediate, to high BP, venous occlusion plethysmographic recordings were performed at the calf and finger vessels. Correlations were calculated between regional blood flow or vascular resistance and BP defined from office and from 24 h ambulatory BP registrations, at rest and during reactive hyperaemia. RESULTS: At any BP level, finger blood flow at rest and during reactive hyperemia was higher than calf blood flow, and resistance was lower. The interval of 90-100 mmHg office diastolic BP was characterized by significantly (p < 0.001) higher resting finger blood flow; the increase in resting muscle blood flow was less pronounced. At rest and during reactive hyperaemia there was a stepwise increase in calf regional vascular resistance in parallel with increasing BP. For the finger circulation, increased vascular resistance was only observed for the higher BP values. Correlations between calf and finger vascular resistances and BP were positive and highly significant over the whole BP range, both for office (0.650 < r < 0.776) and for ambulatory BP (0.531 < r < 0.781). These correlations remained significant after adjustment for the age dependency. Increases in calf and finger blood flow induced by arterial occlusion were highest for the lowest BP quintiles. CONCLUSIONS: Our data further indicated that the capacity to dilate decreased progressively with increasing BP level (from asymptomatic low to high BP) for both calf and finger circulation.

Adult↗

PubMed1993

Skin capillary erythrocyte velocity and mean 24 hour ambulatory blood pressure level.

This study aimed to examine the relation between capillary dynamics and parameters of ambulatory blood pressure (BP) recordings in a range covering very low to high BP (mean arterial BP: 70-140 mm Hg). A total number of 45 subjects underwent a 24 h ambulatory BP recording at 30 min intervals. The subjects did not receive any medication. Then the subjects were subdivided in 5 categories along their mean 24 h arterial BP values < 80, 80-90, 91-105, 106-115, > 115 mm Hg. Nailfold capillaries were examined at the level of the fourth finger using TV-microscopy. Our results demonstrate that erythrocyte velocity could be maintained relatively constant (mean velocities 700-800 microns/s) within the ambulatory mean arterial blood pressure range of 80-115 mm Hg. For very low and high blood pressures significant decreases (p < 0.01) were noted. Using office mean arterial blood pressure comparable results were obtained.

Blood Flow Velocity↗

PubMed1992

Investigation of a possible pharmacokinetic interaction between ibopamine and isosorbide-5-mononitrate.

The possibility of a pharmacokinetic interaction between isosorbide-5-mononitrate (5-ISMN) and epinine, the active metabolite of ibopamine, has been investigated in 8 healthy male subjects given single doses of 200 mg ibopamine and 20 mg 5-ISMN, separately and together. The plasma 5-ISMN concentration-time profile was the same whether 5-ISMN was administered concomitantly with ibopamine or alone [AUC(o-t): 2.24 micrograms.ml-1.h after 5-ISMN alone, 2.16 micrograms.ml-1.h after 5-ISMN+ibopamine]. The plasma concentrations of total and free epinine and the urinary recovery of total epinine, homovanillic acid and dihydroxyphenylacetic acid, too, were not different when ibopamine was administered alone or concomitantly with 5-ISMN. The intake of ibopamine did not change the blood pressure and heart rate. The decrease in diastolic blood pressure induced by 5-ISMN was not influenced by concomitant intake of ibopamine. The observations suggest that in healthy volunteers there is no pharmacokinetic interaction between 5-ISMN and ibopamine.

3,4-Dihydroxyphenylacetic Acid↗