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Biomedical subjects

J Deatrick

Publications and source records attributed to J Deatrick.

9 recordsLinked to original sources
PubMed2003

Constant vigilance: mothers' work parenting young children with type 1 diabetes.

Little is known about the experiences of mothers raising young children with type 1 diabetes. The purpose of this study was to describe the day-to-day experiences of mothers (N = 28) raising young children under 4 years of age with type 1 diabetes. Descriptive, naturalistic inquiry principles were used to interview subjects, as well as to manage and analyze the data. The mothers reported using the management behavior of constant vigilance. Their concerns about hypoglycemia and providing competent care reflected the interplay between their fears and profound sense of responsibility for managing the disease. Mothers reported having to learn the management behaviors and to occasionally adjust the day-to-day management when either severe hypoglycemia or developmental milestones occurred. Although mothers initially had feelings of incompetence with the care they provided, with time, they became very skilled. There were also reports of limited access to babysitting, child care, or respite services. The intensity of their constant vigilance associated with their concerns, responsibility, and lack of supports resulted in some mothers having physical and/or emotional problems. The findings of the study highlight the importance of identifying family and/or community resources that may provide mothers with support that could reduce some of the tremendous stress and burden of responsibility experienced after diagnosis of diabetes.

Adaptation, Psychological↗
PubMed1993

Genetic dissection of pointed, a Drosophila gene encoding two ETS-related proteins.

The Drosophila gene pointed (pnt) is required for the differentiation of a number of tissues during embryogenesis, including the ventral ectoderm, the nervous system, the tracheal system and certain muscle fibers. The phenotypes associated with strong pointed alleles are reflected by a complex pointed expression pattern during embryogenesis. Two promoters, P1 and P2, separated by some 50 kb of genomic sequences, direct the transcription of two different transcript forms, encoding two different proteins related to the ETS family of transcription factors. To assess the individual functions of the two different pointed protein forms, we have generated new pointed alleles affecting either the P1 or the P2 transcript, termed P1 and P2 alleles, respectively. Genetic analysis reveals partial heteroallelic complementation between certain pointed P1 and P2 alleles. Surviving trans-heterozygous flies have rough eyes, abnormal wings and halters, suggesting a requirement for pointed function during their imaginal disc development. Further genetic analysis demonstrates that expression of a given pointed P2 allele depends on trans-acting transcriptional regulatory sequences. We have identified two chromosomal domains with opposite regulatory effects on the transcriptional activity of the pointed P2 promoter, one trans-activates and the other trans-represses pointed P2 expression. By deletion mapping we were able to localize these control regions within the 5' region of the pointed P2 transcript.

Alleles↗
PubMed1992

Localization in situ of polyhomeotic transcripts in Drosophila embryos reveals spatially restricted expression beginning at the blastoderm stage.

Polyhomeotic is a member of a group of genes, the Pc-group responsible for the maintenance of gene expression during development. In particular, the Pc-group of genes is involved in the correct expression of homeotic genes of the bithorax and Antennapedia complexes. Molecular analysis reveals that the Pc-group genes function relatively late in development, once homeotic gene expression has been correctly initiated. This initiation of homeotic gene expression depends on interaction between genes in the segmentation gene hierarchy, the gap and pair-rule genes. The in situ analysis presented here indicates that polyhomeotic transcripts are expressed in a spatially restricted fashion early in development. This blastoderm expression is under the control of genes in the segmentation hierarchy. Given these results, and the role of polyhomeotic in the correct maintenance of homeotic gene expression, I propose that polyhomeotic expression may relay the initiation of homeotic gene expression with other mechanisms involved in the maintenance of this expression, involving the other Pc-group genes.

Animals↗
PubMed1991

The complex genetic locus polyhomeotic in Drosophila melanogaster potentially encodes two homologous zinc-finger proteins.

Differential expression of the homeotic gene complexes, ANT-C and BX-C, of Drosophila melanogaster is partly controlled by trans-regulating factors located outside the two complexes. The complex genetic locus, polyhomeotic (ph), is one of these trans regulators required during development for correct expression of the homeotic selector genes. The ph locus comprises two genetically independent units whose functions are largely redundant. There are two duplicated sequences arranged as a tandem repeat in the ph region, defining two molecular ph units. Sequence analysis of the 28.6 kb of DNA comprising the locus shows varying degrees of sequence conservation between these two molecular units. Long open reading frames with a high degree of conservation have been localized in each tandem repeat. Putative protein products encoded by both the proximal and the distal unit contain several identical or practically identical protein domains: a zinc-finger-forming motif, an alpha-helix motif, a domain rich in serine and threonine residues and stretches of glutamine residues. The presence of these protein domains supports the hypothesis that ph encodes a transcription factor that may function as part of a protein complex. Possible molecular mechanisms leading to the particular structure of the locus are discussed.

Amino Acid Sequence↗
PubMed1987

A complex genetic locus, polyhomeotic, is required for segmental specification and epidermal development in D. melanogaster.

Two mutagenic events are required to make null mutations of polyhomeotic (ph), which suggests that the locus is complex. Amorphic mutations (ph degrees) die in mid-embryogenesis and completely lack ventral thoracic and abdominal epidermal derivatives, whereas single-event mutations lead to transformations similar to those of known dominant gain of function mutants in the Antennapedia and bithorax complexes. After a chromosomal walk, the ph gene was localized using deficiencies and ph mutations that result from DNA rearrangements. Hybridization analyses show that there are two large, duplicated sequences in the ph region, and DNA lesions affecting either one of these repeats alter the function of the ph locus. We propose a model that may account for this unusual functional organization.

Alleles↗
PubMedDate not supplied

A reflection on values in turbulent times.

We discuss how organizations, as cultures, react to times of turbulence, stress, and the importance of their foundational values during those times. By adapting the framework pioneered by the organizational analyst Manfred Kets de Vries, we use psychodynamic concepts to discuss a descriptive typology of behavior in which persons and organizations engage under stress. We also discuss the hazards inherent in losing sight of common core values, the dangers in the disconnects between stated values and behaviors, and how those disconnects can be destructive to organizations and to persons. We conclude with a plan that involves achieving insight, trust, and open communication on which members of organizations can base discussion and find common ground in articulating common core values. Throughout the article, we make applications to nursing organizations to focus attention on the currency of this topic for the profession.

Aggression↗
PubMedDate not supplied

Describing the value of specialized distance education in pediatric oncology nursing.

Working as specialists in a changing environment, advanced practice nurses in pediatric oncology (APN-POs) benefit from specific pediatric oncology education. The graduates of a pediatric nurse practitioner program in pediatric oncology completed a survey about their educational experience and its impact on their current practice. This practitioner program included a subspecialty education in pediatric oncology and an early form of distance learning. The respondents' answers parallel a number of emerging themes in APN-PO practice and education. Employing distance learning methods in providing subspecialty education holds important implications for future APN-PO education and practice and for the health care of communities throughout the country.

Adult↗
PubMedDate not supplied

Autonomy and decision making for health promotion in adolescence.

Autonomy in decision making regarding health issues is a set of skills that develops as part of self-care agency. Adolescence is an important time to begin fostering this autonomy. Providing health-promoting care to adolescents must occur in the context of developmental considerations, legal concerns, and ethical principles. Implications for health care providers include developing trust with the adolescent, teaching the family how to enable the adolescent's self-care, considering the use of advance directives, protecting the rights of minors and parents, implementing confidentiality guidelines concerning the adolescent's care, and formalizing the processes of consent/assent and dissent for health care.

Adolescent↗