The effect of beta-1,3 glucan and cell walls of S. cerevisiae on one hand and of peptidoglycans from strain LDC 15 and C. renale and cell walls of C. Hofmannii on the other hand has been investigated in the experimental leprosy infection in mice. beta-1,3 glucan, by enhancing the function of the reticulo-endothelial system, is the most active inhibitor of the multiplication of Hansen's bacilli. Peptidoglycan of strain LDC 15 is less active and seems non specific.

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PubMedDate not supplied

[Morphologic and biologic properties of diphtherroid organisms (LDC) isolated in leprosy].

Acid-alcohol-fast bacteria are not always detectable in all leprosy lesions. Non acid-fast microorganisms may be associated with acid-fast bacteria. The most frequently isolated strains from leprosy lesions are non acid-fast bacteria, morphologically related to C. diptheirae. Hence their designation as diphtheroïds or LDC (leprosy derived corynebacteria). Their antigenic structure is more closely related to M. leprae and other mycobacteria than to classical corynebacteria. This leads to the hypothesis of a potential role in the pathogenesis of leprosy and their use as an antigen for skin tests by leprosy patients.

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PubMedDate not supplied

Biochemical studies with leprosy-derived corynebacteria.

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Antigens, Bacterial↗

PubMedDate not supplied

Biological properties of diphtheroïd bacteria (LDC) isolated from human leprosy lesions.

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Animals↗